FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313574705> ?p ?o ?g. }

• W2313574705 endingPage "11139" @default.
• W2313574705 startingPage "11130" @default.
• W2313574705 abstract "A one-electron reduction of osmium(IV) complexes trans-[Os(IV)Cl4(Hazole)2], where Hazole = 1H-pyrazole ([1](0)), 2H-indazole ([2](0)), 1H-imidazole ([3](0)), and 1H-benzimidazole ([4](0)), afforded a series of eight new complexes as osmium analogues of KP1019, a lead anticancer drug in clinical trials, with the general formula (cation)[trans-Os(III)Cl4(Hazole)2], where cation = H2pz(+) (H2pz[1]), H2ind(+) (H2ind[2]), H2im(+) (H2im[3]), Ph4P(+) (Ph4P[3]), nBu4N(+) (nBu4N[3]), H2bzim(+) (H2bzim[4]), Ph4P(+) (Ph4P[4]), and nBu4N(+) (nBu4N[4]). All complexes were characterized by elemental analysis, (1)H NMR spectroscopy, electrospray ionization mass spectrometry, UV-vis spectroscopy, cyclic voltammetry, while H2pz[1], H2ind[2], and nBu4[3], in addition, by X-ray diffraction. The reduced species [1](-) and [4](-) are stable in aqueous media in the absence of air oxygen and do not react with small biomolecules such as amino acids and the nucleotide 5'-dGMP. Cell culture experiments in five different human cancer cell lines (HeLa, A549, FemX, MDA-MB-453, and LS-174) and one noncancerous cell line (MRC-5) were performed, and the results were discussed and compared to those for KP1019 and cisplatin. Benzannulation in complexes with similar structure enhances antitumor activity by several orders of magnitude, implicating different mechanisms of action of the tested compounds. In particular, complexes H2ind[2] and H2bzim[4] exhibited significant antiproliferative activity in vitro when compared to H2pz[1] and H2im[3]." @default.
• W2313574705 created "2016-06-24" @default.
• W2313574705 creator A5018849858 @default.
• W2313574705 creator A5045172386 @default.
• W2313574705 creator A5068087465 @default.
• W2313574705 creator A5072430373 @default.
• W2313574705 creator A5087196330 @default.
• W2313574705 creator A5088863049 @default.
• W2313574705 creator A5089631859 @default.
• W2313574705 date "2014-10-07" @default.
• W2313574705 modified "2023-10-13" @default.
• W2313574705 title "Osmium(III) Analogues of KP1019: Electrochemical and Chemical Synthesis, Spectroscopic Characterization, X-ray Crystallography, Hydrolytic Stability, and Antiproliferative Activity" @default.
• W2313574705 cites W127176811 @default.
• W2313574705 cites W1494540281 @default.
• W2313574705 cites W1971152615 @default.
• W2313574705 cites W1976656978 @default.
• W2313574705 cites W1979077184 @default.
• W2313574705 cites W1979106309 @default.
• W2313574705 cites W1980663602 @default.
• W2313574705 cites W1980888914 @default.
• W2313574705 cites W1986585012 @default.
• W2313574705 cites W1989043508 @default.
• W2313574705 cites W1989997288 @default.
• W2313574705 cites W1991904622 @default.
• W2313574705 cites W1994381510 @default.
• W2313574705 cites W1998004353 @default.
• W2313574705 cites W2002021050 @default.
• W2313574705 cites W2005022182 @default.
• W2313574705 cites W2011855362 @default.
• W2313574705 cites W2015091288 @default.
• W2313574705 cites W2017005182 @default.
• W2313574705 cites W2017030176 @default.
• W2313574705 cites W2027895977 @default.
• W2313574705 cites W2030549458 @default.
• W2313574705 cites W2030603525 @default.
• W2313574705 cites W2032405335 @default.
• W2313574705 cites W2037270587 @default.
• W2313574705 cites W2039456073 @default.
• W2313574705 cites W2040357377 @default.
• W2313574705 cites W2041756507 @default.
• W2313574705 cites W2044516912 @default.
• W2313574705 cites W2045343949 @default.
• W2313574705 cites W2047218129 @default.
• W2313574705 cites W2050077837 @default.
• W2313574705 cites W2059020082 @default.
• W2313574705 cites W2066825427 @default.
• W2313574705 cites W2066916023 @default.
• W2313574705 cites W2070625765 @default.
• W2313574705 cites W2072527147 @default.
• W2313574705 cites W2076168971 @default.
• W2313574705 cites W2084831737 @default.
• W2313574705 cites W2093282189 @default.
• W2313574705 cites W2109511270 @default.
• W2313574705 cites W2112253518 @default.
• W2313574705 cites W2121649359 @default.
• W2313574705 cites W2127359954 @default.
• W2313574705 cites W2131350133 @default.
• W2313574705 cites W2134386664 @default.
• W2313574705 cites W2135732933 @default.
• W2313574705 cites W2144114672 @default.
• W2313574705 cites W2151694128 @default.
• W2313574705 cites W2154397719 @default.
• W2313574705 cites W2166349630 @default.
• W2313574705 cites W2170756410 @default.
• W2313574705 cites W2171128566 @default.
• W2313574705 cites W2312283162 @default.
• W2313574705 cites W2317217061 @default.
• W2313574705 cites W2799187975 @default.
• W2313574705 cites W2953065314 @default.
• W2313574705 cites W4210518343 @default.
• W2313574705 cites W4211092410 @default.
• W2313574705 doi "https://doi.org/10.1021/ic501710k" @default.
• W2313574705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25290960" @default.
• W2313574705 hasPublicationYear "2014" @default.
• W2313574705 type Work @default.
• W2313574705 sameAs 2313574705 @default.
• W2313574705 citedByCount "22" @default.
• W2313574705 countsByYear W23135747052014 @default.
• W2313574705 countsByYear W23135747052015 @default.
• W2313574705 countsByYear W23135747052016 @default.
• W2313574705 countsByYear W23135747052017 @default.
• W2313574705 countsByYear W23135747052018 @default.
• W2313574705 countsByYear W23135747052020 @default.
• W2313574705 countsByYear W23135747052021 @default.
• W2313574705 countsByYear W23135747052022 @default.
• W2313574705 countsByYear W23135747052023 @default.
• W2313574705 crossrefType "journal-article" @default.
• W2313574705 hasAuthorship W2313574705A5018849858 @default.
• W2313574705 hasAuthorship W2313574705A5045172386 @default.
• W2313574705 hasAuthorship W2313574705A5068087465 @default.
• W2313574705 hasAuthorship W2313574705A5072430373 @default.
• W2313574705 hasAuthorship W2313574705A5087196330 @default.
• W2313574705 hasAuthorship W2313574705A5088863049 @default.
• W2313574705 hasAuthorship W2313574705A5089631859 @default.
• W2313574705 hasConcept C13965031 @default.
• W2313574705 hasConcept C147789679 @default.
• W2313574705 hasConcept C155647269 @default.
• W2313574705 hasConcept C161790260 @default.

• next