FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313578479> ?p ?o ?g. }

• W2313578479 endingPage "935" @default.
• W2313578479 startingPage "927" @default.
• W2313578479 abstract "Abstract Background: Oral squamous cell carcinoma (OSCC) is a global healthcare problem associated with poor clinical outcomes. Early detection is key to improving patient survival. OSCC may be preceded by clinically recognizable lesions, termed oral potentially malignant disorders (OPMD). As histologic assessment of OPMD does not accurately predict their clinical behavior, biomarkers are required to detect cases at risk of malignant transformation. Epidermal growth factor receptor gene copy number (EGFR GCN) is a validated biomarker in lung non–small cell carcinoma. We examined EGFR GCN in OPMD and OSCC to determine its potential as a biomarker in oral carcinogenesis. Methods: EGFR GCN was examined by in situ hybridization (ISH) in biopsies from 78 patients with OPMD and 92 patients with early-stage (stages I and II) OSCC. EGFR ISH signals were scored by two pathologists and a category assigned by consensus. The data were correlated with patient demographics and clinical outcomes. Results: OPMD with abnormal EGFR GCN were more likely to undergo malignant transformation than diploid cases. EGFR genomic gain was detected in a quarter of early-stage OSCC, but did not correlate with clinical outcomes. Conclusion: These data suggest that abnormal EGFR GCN has clinical utility as a biomarker for the detection of OPMD destined to undergo malignant transformation. Prospective studies are required to verify this finding. It remains to be determined if EGFR GCN could be used to select patients for EGFR-targeted therapies. Impact: Abnormal EGFR GCN is a potential biomarker for identifying OPMD that are at risk of malignant transformation. Cancer Epidemiol Biomarkers Prev; 25(6); 927–35. ©2016 AACR." @default.
• W2313578479 created "2016-06-24" @default.
• W2313578479 creator A5004351196 @default.
• W2313578479 creator A5008596795 @default.
• W2313578479 creator A5013460026 @default.
• W2313578479 creator A5024164941 @default.
• W2313578479 creator A5027935144 @default.
• W2313578479 creator A5035330194 @default.
• W2313578479 creator A5049247909 @default.
• W2313578479 creator A5071804719 @default.
• W2313578479 creator A5078131901 @default.
• W2313578479 creator A5079491232 @default.
• W2313578479 creator A5090586423 @default.
• W2313578479 date "2016-05-31" @default.
• W2313578479 modified "2023-10-14" @default.
• W2313578479 title "Changes in Epidermal Growth Factor Receptor Gene Copy Number during Oral Carcinogenesis" @default.
• W2313578479 cites W1970159404 @default.
• W2313578479 cites W1981219430 @default.
• W2313578479 cites W1985577249 @default.
• W2313578479 cites W1990956554 @default.
• W2313578479 cites W1994402893 @default.
• W2313578479 cites W1995242599 @default.
• W2313578479 cites W1996106675 @default.
• W2313578479 cites W2003171254 @default.
• W2313578479 cites W2005204942 @default.
• W2313578479 cites W2007649418 @default.
• W2313578479 cites W2007657332 @default.
• W2313578479 cites W2016081624 @default.
• W2313578479 cites W2019443090 @default.
• W2313578479 cites W2020627627 @default.
• W2313578479 cites W2024727160 @default.
• W2313578479 cites W2029762417 @default.
• W2313578479 cites W2033544246 @default.
• W2313578479 cites W2040452911 @default.
• W2313578479 cites W2050380402 @default.
• W2313578479 cites W2051120695 @default.
• W2313578479 cites W2064128515 @default.
• W2313578479 cites W2081414148 @default.
• W2313578479 cites W2087385192 @default.
• W2313578479 cites W2095257093 @default.
• W2313578479 cites W2102639464 @default.
• W2313578479 cites W2106787323 @default.
• W2313578479 cites W2108142765 @default.
• W2313578479 cites W2115653059 @default.
• W2313578479 cites W2116116421 @default.
• W2313578479 cites W2117692326 @default.
• W2313578479 cites W2127784700 @default.
• W2313578479 cites W2130465901 @default.
• W2313578479 cites W2131707929 @default.
• W2313578479 cites W2136969848 @default.
• W2313578479 cites W2138604360 @default.
• W2313578479 cites W2143171062 @default.
• W2313578479 cites W2147051615 @default.
• W2313578479 cites W2149412903 @default.
• W2313578479 cites W2159015502 @default.
• W2313578479 cites W2159024695 @default.
• W2313578479 cites W2163501127 @default.
• W2313578479 cites W2169947883 @default.
• W2313578479 cites W2170578560 @default.
• W2313578479 doi "https://doi.org/10.1158/1055-9965.epi-15-0949" @default.
• W2313578479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27197272" @default.
• W2313578479 hasPublicationYear "2016" @default.
• W2313578479 type Work @default.
• W2313578479 sameAs 2313578479 @default.
• W2313578479 citedByCount "13" @default.
• W2313578479 countsByYear W23135784792016 @default.
• W2313578479 countsByYear W23135784792017 @default.
• W2313578479 countsByYear W23135784792018 @default.
• W2313578479 countsByYear W23135784792019 @default.
• W2313578479 countsByYear W23135784792020 @default.
• W2313578479 countsByYear W23135784792021 @default.
• W2313578479 countsByYear W23135784792022 @default.
• W2313578479 crossrefType "journal-article" @default.
• W2313578479 hasAuthorship W2313578479A5004351196 @default.
• W2313578479 hasAuthorship W2313578479A5008596795 @default.
• W2313578479 hasAuthorship W2313578479A5013460026 @default.
• W2313578479 hasAuthorship W2313578479A5024164941 @default.
• W2313578479 hasAuthorship W2313578479A5027935144 @default.
• W2313578479 hasAuthorship W2313578479A5035330194 @default.
• W2313578479 hasAuthorship W2313578479A5049247909 @default.
• W2313578479 hasAuthorship W2313578479A5071804719 @default.
• W2313578479 hasAuthorship W2313578479A5078131901 @default.
• W2313578479 hasAuthorship W2313578479A5079491232 @default.
• W2313578479 hasAuthorship W2313578479A5090586423 @default.
• W2313578479 hasBestOaLocation W23135784791 @default.
• W2313578479 hasConcept C121608353 @default.
• W2313578479 hasConcept C126322002 @default.
• W2313578479 hasConcept C143998085 @default.
• W2313578479 hasConcept C2776256026 @default.
• W2313578479 hasConcept C2779438470 @default.
• W2313578479 hasConcept C2781197716 @default.
• W2313578479 hasConcept C31033888 @default.
• W2313578479 hasConcept C502942594 @default.
• W2313578479 hasConcept C55493867 @default.
• W2313578479 hasConcept C555283112 @default.
• W2313578479 hasConcept C71924100 @default.
• W2313578479 hasConcept C86803240 @default.
• W2313578479 hasConceptScore W2313578479C121608353 @default.

• next