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• W2313594071 abstract "Silvestrol (1) and episilvestrol (2) are protein synthesis inhibitors, and the former has shown efficacy in multiple mouse models of cancer; however, the selectivity of these potent cytotoxic natural products has not been described. Herein, it is demonstrated that eukaryotic initiation factors eIF4AI/II were the only proteins detected to bind silvestrol (1) and biotinylated episilvestrol (9) by affinity purification. Our study demonstrates the remarkable selectivity of these promising chemotherapeutics." @default.
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• W2313594071 date "2013-03-05" @default.
• W2313594071 modified "2023-10-16" @default.
• W2313594071 title "Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II" @default.
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• W2313594071 doi "https://doi.org/10.1021/ol400401d" @default.
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