Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313597955> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2313597955 endingPage "2826" @default.
- W2313597955 startingPage "2826" @default.
- W2313597955 abstract "目的：探讨人肝癌细胞（MHCC-97H）和人胆管癌细胞（human bile duct carcinoma cell,RBE）中酪氨酸激酶受体c-Met前体（pro-Met）的N-糖基化修饰对c-Met功能的影响.方法：分别用N-糖基化抑制剂衣霉素、蛋白酶体抑制剂MG132、蛋白合成抑制剂放线菌酮及c-Met抑制剂PF-2341066处理MHCC-97H细胞和RBE细胞,采用Western blot、免疫荧光及激光共聚焦显微镜等方法分析pro-Met的N-糖基化修饰对c-Met功能的影响.结果：MHCC-97H细胞和RBE细胞中磷脂酰肌醇3-激酶（phosphatidy linositol 3 kinase/AktPI3K/Akt）以及有丝分裂原活化蛋白激酶/细胞外信号调节激酶（mitogen-activated proteinkinase/extracellular signal-regulated kinaseMEK/ERK）是c-Met下游信号通路.c-Met是一种N-糖基化修饰的蛋白分子.c-Met的N-糖基化修饰源于pro-Met的N-糖基化.非糖基化pro-Met虽然能够发生磷酸化修饰,但不能有效激活c-Met下游信号通路.c-Met的成熟和膜定位需要其糖基化修饰.结论：c-Met的N-糖基化修饰是维持其功能所必需的." @default.
- W2313597955 created "2016-06-24" @default.
- W2313597955 creator A5004498049 @default.
- W2313597955 creator A5009193547 @default.
- W2313597955 creator A5014484115 @default.
- W2313597955 creator A5029007916 @default.
- W2313597955 creator A5037892299 @default.
- W2313597955 creator A5074666437 @default.
- W2313597955 creator A5077552230 @default.
- W2313597955 creator A5081306323 @default.
- W2313597955 creator A5089235301 @default.
- W2313597955 date "2014-01-01" @default.
- W2313597955 modified "2023-09-26" @default.
- W2313597955 title "Effect of N-linked glycosylation modification of pro-Met on function of c-Met" @default.
- W2313597955 doi "https://doi.org/10.11569/wcjd.v22.i20.2826" @default.
- W2313597955 hasPublicationYear "2014" @default.
- W2313597955 type Work @default.
- W2313597955 sameAs 2313597955 @default.
- W2313597955 citedByCount "0" @default.
- W2313597955 crossrefType "journal-article" @default.
- W2313597955 hasAuthorship W2313597955A5004498049 @default.
- W2313597955 hasAuthorship W2313597955A5009193547 @default.
- W2313597955 hasAuthorship W2313597955A5014484115 @default.
- W2313597955 hasAuthorship W2313597955A5029007916 @default.
- W2313597955 hasAuthorship W2313597955A5037892299 @default.
- W2313597955 hasAuthorship W2313597955A5074666437 @default.
- W2313597955 hasAuthorship W2313597955A5077552230 @default.
- W2313597955 hasAuthorship W2313597955A5081306323 @default.
- W2313597955 hasAuthorship W2313597955A5089235301 @default.
- W2313597955 hasBestOaLocation W23135979551 @default.
- W2313597955 hasConcept C100631289 @default.
- W2313597955 hasConcept C108625454 @default.
- W2313597955 hasConcept C126322002 @default.
- W2313597955 hasConcept C14036430 @default.
- W2313597955 hasConcept C181199279 @default.
- W2313597955 hasConcept C185592680 @default.
- W2313597955 hasConcept C206212055 @default.
- W2313597955 hasConcept C2777313579 @default.
- W2313597955 hasConcept C3018559029 @default.
- W2313597955 hasConcept C30324644 @default.
- W2313597955 hasConcept C511355011 @default.
- W2313597955 hasConcept C55493867 @default.
- W2313597955 hasConcept C71924100 @default.
- W2313597955 hasConcept C86803240 @default.
- W2313597955 hasConcept C95444343 @default.
- W2313597955 hasConceptScore W2313597955C100631289 @default.
- W2313597955 hasConceptScore W2313597955C108625454 @default.
- W2313597955 hasConceptScore W2313597955C126322002 @default.
- W2313597955 hasConceptScore W2313597955C14036430 @default.
- W2313597955 hasConceptScore W2313597955C181199279 @default.
- W2313597955 hasConceptScore W2313597955C185592680 @default.
- W2313597955 hasConceptScore W2313597955C206212055 @default.
- W2313597955 hasConceptScore W2313597955C2777313579 @default.
- W2313597955 hasConceptScore W2313597955C3018559029 @default.
- W2313597955 hasConceptScore W2313597955C30324644 @default.
- W2313597955 hasConceptScore W2313597955C511355011 @default.
- W2313597955 hasConceptScore W2313597955C55493867 @default.
- W2313597955 hasConceptScore W2313597955C71924100 @default.
- W2313597955 hasConceptScore W2313597955C86803240 @default.
- W2313597955 hasConceptScore W2313597955C95444343 @default.
- W2313597955 hasIssue "20" @default.
- W2313597955 hasLocation W23135979551 @default.
- W2313597955 hasOpenAccess W2313597955 @default.
- W2313597955 hasPrimaryLocation W23135979551 @default.
- W2313597955 hasRelatedWork W1907834491 @default.
- W2313597955 hasRelatedWork W1973089523 @default.
- W2313597955 hasRelatedWork W1978351897 @default.
- W2313597955 hasRelatedWork W2100064388 @default.
- W2313597955 hasRelatedWork W2143962842 @default.
- W2313597955 hasRelatedWork W217374264 @default.
- W2313597955 hasRelatedWork W2332157425 @default.
- W2313597955 hasRelatedWork W2357132075 @default.
- W2313597955 hasRelatedWork W2917615055 @default.
- W2313597955 hasRelatedWork W3137565780 @default.
- W2313597955 hasVolume "22" @default.
- W2313597955 isParatext "false" @default.
- W2313597955 isRetracted "false" @default.
- W2313597955 magId "2313597955" @default.
- W2313597955 workType "article" @default.