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- W2313644375 abstract "Eleven patients with primary aldosteronism (PA) and 7 patients with essential hypertension were hospitalized, and blood samples were collected every 4 hours for measurement of plasma aldosterone concentration (PAC), plasma renin activity (PRA) and plasma cortisol concentration. A total of 6 mg of dexamethasone was administered for 2 days and blood samples were drawn. In 6 cases of primary aldosteronism, spironolactone was administered for more than 3 months, and the examination was repeated. The hormonal circadian rhythms were analyzed by the Cosinor method.PAC in PA was high in mesor (420.2 ± 127.7pg/ml) with a significant rhythm (p <0.05); the acrophase was 6 : 15 (clock time). Dexamethasone slightly decreased the mesor, while PAC circadian rhythm was observed. PRA was suppressed in patients with PA, and had a significant circadian rhythm only before dexamethasone administration.PAC in essential hypertension showed a significant circadian rhythm (p <0.05); the acrophase was 5 : 44 (clock time). The rhythm was also observed after dexamethasone administration. No circadian rhythm of PRA was observed in essential hypertension.Following long term spironolactone treatment, PAC in PA was observed to still be high and showed an apparent circadian rhythm identical to that observed before spironolactone treatment. ACTH suppression with dexamethasone caused a forward shift in the acrophase (p <0.05). Spironolactone treatment increased PRA but its circadian rhythm was not observed.These results suggest that the renin-angiotensin-aldosterone system play no role in regulation of the circadian rhythm of PAC in PA with long term spironolactone treatment. ACTH seemed to participate in phase shifts of the circadian rhythm of PAC." @default.
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- W2313644375 date "1992-01-01" @default.
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- W2313644375 title "EFFECT OF SPIRONOLACTONE ON CIRCADIAN RHYTHM OF PLASMA RENIN ACTIVITY, PLASMA ALDOSTERONE AND CORTISOL IN PRIMARY ALDOSTERONISM" @default.
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- W2313644375 doi "https://doi.org/10.2974/kmj1951.42.179" @default.
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