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• W2313645038 abstract "Event Abstract Back to Event Synaptic consolidation across multiple timescales Lorric Ziegler1 and Wulfram Gerstner1* 1 Ecole Polytechnique Federale de Lausanne, EPFL IC ISIM LCN1, Switzerland The brain is bombarded with a continuous stream of sensory events, but retains only a small subset in memory. The selectivity of memory formation prevents our memory from being overloaded with irrelevant items that would rapidly bring the brain to its storage limit; moreover, selectivity also prevents overwriting previously formed memories with new ones. Memory formation in the hippocampus, as well as in other brain regions, is thought to be linked to changes in the synaptic connections between neurons. In this view, sensory events imprint traces at the level of synapses that reflect potential memory items. The question of memory selectivity can therefore be reformulated as follows: what are the reasons and conditions that some synaptic traces fade away whereas others are consolidated and persist? Experimentally, changes in synaptic strength induced by 'Hebbian' protocols fade away over a few hours (early long-term potentiation or e-LTP), unless these changes are consolidated. The experiments and conceptual theory of synaptic tagging and capture (STC) provide a mechanistic explanation for the processes involved in consolidation. This theory suggests that the initial trace of synaptic plasticity sets a tag at the synapse, which then serves as a marker for potential consolidation of the changes in synaptic efficacy. The actual consolidation processes, transforming e-LTP into late LTP (l-LTP), require the capture of plasticity-related proteins (PRP). We translate the above conceptual model into a compact computational model that accounts for a wealth of in vitro data including experiments on cross-tagging, tag-resetting and depotentiation. A central ingredient is that synaptic traces are described with several variables that evolve on different time scales. Consolidation requires the transmission of information from a 'fast' synaptic trace to a 'slow' one through a 'write' process, including the formation of tags and the production of PRP for the transition from e-LTP to l-LTP. Interestingly, experimental work has linked the production of PRP and the maintenance of memory to the presence of neuromodulators such as dopamine, that can be caused by behavioral and environmental cues such as novelty, reward prediction error, aversive events or attention. We also show that our model of synaptic plasticity and consolidation when simulated and implemented in a network of thousands of model neurons can account for in vivo behavioral data that links memory maintenance to novelty. This supports the hypothesis that behavioral tagging and synaptic tagging could be based on the same mechanistic process. Keywords: synaptic plasticity, metaplasticity, Neuromodulation, Dopamine, tagging, consolidation, behavioral tagging, Memory Conference: 4th NAMASEN Training Workshop - Dendrites 2014, Heraklion, Greece, 1 Jul - 4 Jul, 2014. Presentation Type: Oral presentation Topic: functional or structural plasticity and homeostasis Citation: Ziegler L and Gerstner W (2014). Synaptic consolidation across multiple timescales. Front. Syst. Neurosci. Conference Abstract: 4th NAMASEN Training Workshop - Dendrites 2014. doi: 10.3389/conf.fnsys.2014.05.00011 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Apr 2014; Published Online: 12 Jun 2014. * Correspondence: Prof. Wulfram Gerstner, Ecole Polytechnique Federale de Lausanne, EPFL IC ISIM LCN1, Lausanne, 1015, Switzerland, wulfram.gerstner@epfl.ch Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lorric Ziegler Wulfram Gerstner Google Lorric Ziegler Wulfram Gerstner Google Scholar Lorric Ziegler Wulfram Gerstner PubMed Lorric Ziegler Wulfram Gerstner Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2313645038 title "Synaptic consolidation across multiple timescales" @default.
• W2313645038 doi "https://doi.org/10.3389/conf.fnsys.2014.05.00011" @default.
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