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• W2313663313 abstract "Event Abstract Back to Event Retrograde nitric oxide signaling at hippocampal synapses during development Csaba Cserép1*, András Szonyi1, Eszter Szabadits1, Jan D. Vente2, Tamás Freund1 and Gábor Nyiri1 1 Hungarian Academy of Science, Laboratory of Cerebral Cortex Research in the Institute of Experimental Medicine, Hungary 2 Maastricht University, Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Netherlands In the early postnatal period, GABA is known to depolarize hippocampal pyramidal neurons, while it becomes hyperpolarizing after the maturation of functional glutamatergic synapses during the 2nd postnatal week. The regulation of synaptic transmission in the early postnatal period is poorly understood. Nitric oxide (NO) is an important retrograde messenger in the adult brain both at glutamatergic and - as we showed recently - at GABAergic synapses. In addition, retrograde NO signaling plays an important role in short- and long-term synaptic plasticity. Recent studies demonstrated that disrupting NO signaling during development leads to morphological damage and functional impairments of neuronal network operations. Here we examined the subcellular localization of elements of the NO signaling pathway during early postnatal development. Using immuno-electron microscopy, we describe that neuronal nitric oxide synthase (nNOS) is present in the postsynaptic active zones of both GABAergic and glutamatergic synapses in the developing mouse hippocampus. In double-labeled preparations we found that both subunits of the NO receptor (nitric oxide sensitive guanylyl cyclase) were present in GABAergic terminals. NO receptor activation leads to production of the second messenger cGMP. To test the functionality of this signaling pathway, we treated acute slices of early postnatal hippocampi with the NO donor sodium nitroprusside. This resulted in cGMP production in GABAergic terminals, which could be completely abolished by the NO receptor inhibitor. Our results demonstrate that elements of the retrograde NO signaling pathway are present in synapses of the 4 to 14-day-old mouse hippocampi. We propose that this pathway is able to regulate release probability in a synapse-specific manner and thereby control early network activity patterns. Conference: IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010. Presentation Type: Poster Presentation Topic: Development Citation: Cserép C, Szonyi A, Szabadits E, Vente JD, Freund T and Nyiri G (2010). Retrograde nitric oxide signaling at hippocampal synapses during development. Front. Neurosci. Conference Abstract: IBRO International Workshop 2010. doi: 10.3389/conf.fnins.2010.10.00005 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 14 Apr 2010; Published Online: 14 Apr 2010. * Correspondence: Csaba Cserép, Hungarian Academy of Science, Laboratory of Cerebral Cortex Research in the Institute of Experimental Medicine, Budapest, Hungary, cserep@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Csaba Cserép András Szonyi Eszter Szabadits Jan D Vente Tamás Freund Gábor Nyiri Google Csaba Cserép András Szonyi Eszter Szabadits Jan D Vente Tamás Freund Gábor Nyiri Google Scholar Csaba Cserép András Szonyi Eszter Szabadits Jan D Vente Tamás Freund Gábor Nyiri PubMed Csaba Cserép András Szonyi Eszter Szabadits Jan D Vente Tamás Freund Gábor Nyiri Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2313663313 title "Retrograde nitric oxide signaling at hippocampal synapses during development" @default.
• W2313663313 doi "https://doi.org/10.3389/conf.fnins.2010.10.00005" @default.
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