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- W2313668843 abstract "Summary and conclusions1. The apparent antibacterial activity of nitrofurantoin (pKa 7.2) against E. coli, S. aureus, and Pr. vulgaris is increased as the pH of the medium is lowered. 2. P. aeruginosa becomes susceptible to nitrofurantoin in the presence of 1% or more urea and in an acidic medium (pH 6). 3. Incorporation of 2% NH4Cl as a urinary acidifier in the diet of rats did not have a major effect on the nitrofurantoin concentrations attained in the urine or on the total amount of nitrofurantoin excreted. 4. The ingestion of a high protein diet by albino rats to increase urea excretion did not adversely affect the urinary concentration nor the total amount of nitrofurantoin excreted. S. Albino rats receiving 0.1% nitrofurantoin (about 10 × calculated human dose) and 2% NH4Cl in the diet for a 2-week period showed no evidence of crystalluria or kidney pathology." @default.
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- W2313668843 date "1967-07-01" @default.
- W2313668843 modified "2023-09-23" @default.
- W2313668843 title "Effect of pH and of Urea on Nitrofurantoin Activity" @default.
- W2313668843 doi "https://doi.org/10.3181/00379727-125-32246" @default.
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