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- W2313672008 abstract "tropic agents. Weak bases such as chloroquine, ammonium chloride, and acridine orange caused gut swelling upon protonation. The latter compound fluoresced a bright orange indicating the acidic nature of the gut contents. Hydrolysis of ingested L-amino acid methyl esters also resulted in gut swelling, indicating the nonpermeant nature of the resulting L-amino acids. Neither age nor feeding status influenced these swelling effects. Treatment of schistosomula with D-amino acid esters, free L-amino acids, or methanol had no effect. Thin-layer chromatographic analysis of worms treated with radiolabeled L-leucine methyl ester provided evidence that the ester was hydrolyzed. These results support the premise that the schistosome gut is an acidic compartment and is reminiscent of a secondary lysosome in its reaction to lysosomotropic agents. Bogitsh (1985a) proposed that the schistosome gut is analogous to a secondary lysosome as both are potentially membrane-delimited areas containing acid hydrolases and food in varying stages of digestion. Fundamental to this proposition is that the schistosome gut is an acid compartment and that the acidity not only facilitates the digestive action of the gut-secreted enzymes but also denatures ingested proteins, thus rendering them more vulnerable to enzymatic action. The premise that the gut content is acid is based on indirect biochemical and cytochemical evidence. For instance, Timms and Bueding (1959) characterized an endopeptidase from adult Schistosoma mansoni that optimally hydrolyzed host hemoglobin at pH 3.9. Subsequently, Senft and associates (Grant and Senft, 1971; Sauer and" @default.
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- W2313672008 date "1991-04-01" @default.
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- W2313672008 title "The In vitro Effects of Various Lysosomotropic Agents on the Gut of Schistosoma mansoni Schistosomula" @default.
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- W2313672008 doi "https://doi.org/10.2307/3283078" @default.
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