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• W2313683181 abstract "Event Abstract Back to Event Multi-physical simulation for cellular morphogenesis based on dynamic cytoskeleton Seigo Nonaka1*, Honda Naoki1 and Shin Ishii1 1 Kyoto University, Graduate School of Informatics, Japan During embryonic development, cells differentiate to various kinds with specific morphologies which are reflected by cellular functions. For examples, motile cells have structures of lamellipodia and filopodia and neurons have prominent polarized morphology with axon and dendrites. The cellular morphogenesis is a complicated phenomenon, during which a cell receives extracellular signals, processes this information through intracellular signal transduction, and regulates the reorganization of cytoskeleton such as actin filament and microtubules, which directly control the cell shape. Although microscopic properties of cytoskeleton such as (de-) polymerization, capping and branching have been identified, filament-based understanding for macroscopic morphogenesis remains largely unclear. To fill in this hierarchical gap between micro- and macro-scopic phenomena, we have constructed a multi-physical simulator for dynamics of cellular morphology, integrating reaction-diffusion, actin filament and plasma membrane. In this simulation, reaction-diffusion field and membrane are discretized as compartments and nodes, respectively. Actin filament is addressed as a rigid line segment and is assumed to generate driving force against the membrane based on elastic-ratchet model. Using this simulator, we demonstrated chemotactic migration. For realistic simulation, there was a problem of computational cost, because a number of actin filaments are expressed inside a cell (#10^8). The highest-cost calculation is collision detection between actin filament and membrane nodes. To resolve this problem, we adopt parallelization technique (in computer science) to allocate the partial simulation processes related to actin filament to multiple CPUs and calculate the collision detection independently. Then, it successfully accelerated the run-speed almost proportional to the number of CPU in the limited condition. In this presentation, we will report the mathematical model for simulation and some biological applications. Conference: Neuroinformatics 2010 , Kobe, Japan, 30 Aug - 1 Sep, 2010. Presentation Type: Poster Presentation Topic: Spotlight presentations Citation: Nonaka S, Naoki H and Ishii S (2010). Multi-physical simulation for cellular morphogenesis based on dynamic cytoskeleton. Front. Neurosci. Conference Abstract: Neuroinformatics 2010 . doi: 10.3389/conf.fnins.2010.13.00122 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Jun 2010; Published Online: 16 Jun 2010. * Correspondence: Seigo Nonaka, Kyoto University, Graduate School of Informatics, Uji-shi, Japan, nonaka-s@sys.i.kyoto-u.ac.jp Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Seigo Nonaka Honda Naoki Shin Ishii Google Seigo Nonaka Honda Naoki Shin Ishii Google Scholar Seigo Nonaka Honda Naoki Shin Ishii PubMed Seigo Nonaka Honda Naoki Shin Ishii Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2313683181 title "Multi-physical simulation for cellular morphogenesis based on dynamic cytoskeleton" @default.
• W2313683181 doi "https://doi.org/10.3389/conf.fnins.2010.13.00122" @default.
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