Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313696003> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2313696003 endingPage "154" @default.
- W2313696003 startingPage "150" @default.
- W2313696003 abstract "Menogaril is a semisynthetic anthracycline that is less cardiotoxic than doxorubicin in a preclinical model. We conducted a phase II trial to determine the activity of menogaril in hormone-refractory prostate cancer. Between October 1985 and November 1987, 32 eligible patients were enrolled and were divided into good- and poor-risk categories, the latter being defined by prior radiotherapy to less than one third of the marrow-containing skeleton. Good-risk patients received a starting dose of 200 mg/m2 by 60-minute IV infusion, whereas the poor-risk patients received 160 mg/m2. Treatment was repeated every 3 weeks until disease progression. Menogaril caused leukopenia in 90% of patients, of whom 47% had grade III or IV toxicity. Thrombocytopenia was uncommon and mild, with only three patients (9%) experiencing grade II toxicity. Nonhematologic toxicity included mucositis (9%), and mild weight loss in 33% of patients. Nine patients (28%) had stable disease of 3 or more months' duration. There were no objective partial or complete responses. The median time to progression for the entire group was 10 weeks, and the median survival time for all patients was 24 weeks. Because of appreciable toxicity and limited antitumor activity, further study of menogaril cannot be recommended in hormone-refractory prostate cancer." @default.
- W2313696003 created "2016-06-24" @default.
- W2313696003 creator A5010671566 @default.
- W2313696003 creator A5016064449 @default.
- W2313696003 creator A5040125749 @default.
- W2313696003 creator A5045746656 @default.
- W2313696003 creator A5065161783 @default.
- W2313696003 creator A5068737034 @default.
- W2313696003 creator A5075217067 @default.
- W2313696003 date "2001-04-01" @default.
- W2313696003 modified "2023-10-01" @default.
- W2313696003 title "Phase II Evaluation of Menogaril in Advanced Prostate Cancer" @default.
- W2313696003 cites W2003374169 @default.
- W2313696003 cites W2013031942 @default.
- W2313696003 cites W2068776651 @default.
- W2313696003 cites W2076668534 @default.
- W2313696003 cites W2258872784 @default.
- W2313696003 doi "https://doi.org/10.1097/00000421-200104000-00011" @default.
- W2313696003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11319290" @default.
- W2313696003 hasPublicationYear "2001" @default.
- W2313696003 type Work @default.
- W2313696003 sameAs 2313696003 @default.
- W2313696003 citedByCount "2" @default.
- W2313696003 countsByYear W23136960032020 @default.
- W2313696003 crossrefType "journal-article" @default.
- W2313696003 hasAuthorship W2313696003A5010671566 @default.
- W2313696003 hasAuthorship W2313696003A5016064449 @default.
- W2313696003 hasAuthorship W2313696003A5040125749 @default.
- W2313696003 hasAuthorship W2313696003A5045746656 @default.
- W2313696003 hasAuthorship W2313696003A5065161783 @default.
- W2313696003 hasAuthorship W2313696003A5068737034 @default.
- W2313696003 hasAuthorship W2313696003A5075217067 @default.
- W2313696003 hasConcept C121332964 @default.
- W2313696003 hasConcept C121608353 @default.
- W2313696003 hasConcept C126322002 @default.
- W2313696003 hasConcept C141071460 @default.
- W2313696003 hasConcept C142424586 @default.
- W2313696003 hasConcept C2778496288 @default.
- W2313696003 hasConcept C2780192828 @default.
- W2313696003 hasConcept C2780873365 @default.
- W2313696003 hasConcept C29730261 @default.
- W2313696003 hasConcept C71924100 @default.
- W2313696003 hasConcept C87355193 @default.
- W2313696003 hasConcept C90924648 @default.
- W2313696003 hasConceptScore W2313696003C121332964 @default.
- W2313696003 hasConceptScore W2313696003C121608353 @default.
- W2313696003 hasConceptScore W2313696003C126322002 @default.
- W2313696003 hasConceptScore W2313696003C141071460 @default.
- W2313696003 hasConceptScore W2313696003C142424586 @default.
- W2313696003 hasConceptScore W2313696003C2778496288 @default.
- W2313696003 hasConceptScore W2313696003C2780192828 @default.
- W2313696003 hasConceptScore W2313696003C2780873365 @default.
- W2313696003 hasConceptScore W2313696003C29730261 @default.
- W2313696003 hasConceptScore W2313696003C71924100 @default.
- W2313696003 hasConceptScore W2313696003C87355193 @default.
- W2313696003 hasConceptScore W2313696003C90924648 @default.
- W2313696003 hasIssue "2" @default.
- W2313696003 hasLocation W23136960031 @default.
- W2313696003 hasLocation W23136960032 @default.
- W2313696003 hasOpenAccess W2313696003 @default.
- W2313696003 hasPrimaryLocation W23136960031 @default.
- W2313696003 hasRelatedWork W1524284550 @default.
- W2313696003 hasRelatedWork W1531122021 @default.
- W2313696003 hasRelatedWork W1980701009 @default.
- W2313696003 hasRelatedWork W2023341096 @default.
- W2313696003 hasRelatedWork W2035460761 @default.
- W2313696003 hasRelatedWork W2047967234 @default.
- W2313696003 hasRelatedWork W2293550071 @default.
- W2313696003 hasRelatedWork W2351796763 @default.
- W2313696003 hasRelatedWork W2439875401 @default.
- W2313696003 hasRelatedWork W2468742732 @default.
- W2313696003 hasVolume "24" @default.
- W2313696003 isParatext "false" @default.
- W2313696003 isRetracted "false" @default.
- W2313696003 magId "2313696003" @default.
- W2313696003 workType "article" @default.