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- W2313702419 abstract "A dosimetric analysis to compare the dose and volume of bladder, rectum and urethra using high-dose-rate brachytherapy (HDR-BT), Helical Tomotherapy (HT) and conventional linac based intensity-modulated radiation therapy (IMRT) in the treatment of prostate cancer. Ten successive patients with adenocarcinoma of the prostate treated with HDR-BT to a dose of 3900 cGy in six 650 cGy fractions were used for this study. An additional three theoretical plans for each patient were computed: (1) 7600cGy, in 200 cGy fractions, HT plan with no expansion from the HDR-BT PTV target, (2) 7600 cGy, in 200 cGy fractions, HT plan with 8mm circumferential expansion, except 5mm posteriorly and (3) 7600 cGy, in 200 cGy fractions, conventional linac 9 beam IMRT plan with similar expansions as above. Dose to the normal structures were calculated and Dose-volume histograms (DVH) were plotted for comparisons of all techniques. The V200, V150, V120, V100, V80, V60, V40, V20 and V10 were compared. Data were compared across treatment approaches for each site and percent dose using Friedman tests. Data are reported in mean + standard deviation in Table 1. HDR brachytherapy can provide better sparing of the rectum, bladder and urethra while delivering a higher dose to the prostate. This is especially true across low doses, < 40%, which may be beneficial for long term side effects as there is less integral dose with HDR brachytherapy when compared to complex external beam delivery systems such at Helical Tomotherapy and linac based IMRT.Table 1Volume with Percent Dose by Treatment ApproachHDR BrachytherapyTomotherapy Expanded PTVTomotherapy No ExpansionPinnaclepBladder20%64.3 ± 26.689.5 ± 31.656.3 ± 23.459.2 ± 16.90.00240%26.0 ± 14.757.1 ± 25.028.3 ± 13.536.0 ± 11.2<0.00160%10.4 ± 6.237.4 ± 18.214.3 ± 6.721.6 ± 6.7<0.00180%3.2 ± 2.923.5 ± 10.95.5 ± 2.710.8 ± 2.70.001100%0.4 ± 0.79.9 ± 4.60.1 ± 0.10.3 ± 0.50.279Urethra60%2.5 ± 0.62.8 ± 0.62.6 ± 0.72.8 ± 0.6<0.00180%2.2 ± 0.62.8 ± 0.62.3 ± 0.72.6 ± 0.6<0.001100%1.6 ± 0.62.5 ± 0.61.9 ± 0.71.2 ± 0.40.033120%0.0 ± 0.00.0 ± 0.00.0 ± 0.00.0 ± 0.00.995Rectum20%47.6 ± 14.350.1 ± 19.929.1 ± 13.044.7 ± 15.30.00140%16.9 ± 7.630.6 ± 15.310.3 ± 5.527.5 ± 9.40.00260%4.7 ± 3.014.4 ± 9.43.7 ± 2.814.0 ± 4.60.00380%0.6 ± 0.65.9 ± 3.31.0 ± 1.35.4 ± 2.40.003100%0.0 ± 0.01.1 ± 1.20.0 ± 0.10.1 ± 0.10.100 Open table in a new tab" @default.
- W2313702419 created "2016-06-24" @default.
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- W2313702419 date "2014-03-01" @default.
- W2313702419 modified "2023-09-27" @default.
- W2313702419 title "Dosimetric Comparison of High-Dose-Rate Brachytherapy, Helical Tomotherapy and Linac-Based Intensity Modulated Radiaiton Therapy for Definitive Localized Prostate Cancer Treatment" @default.
- W2313702419 doi "https://doi.org/10.1016/j.brachy.2014.02.322" @default.
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