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- W2313714319 abstract "The mechanisms by which seven transmembrane receptors activate p42mapk/p44mapk are not well defined although p21ras- and protein kinase C (PKC)-dependent pathways have been implicated, typically for Gi- and Gq-coupled receptors, respectively. Here, we demonstrate that in Rat-1 cells transfected with the Gq-coupled bombesin/gastrin releasing peptide receptor, bombesin stimulated activation of p42mapk that was not inhibited by the specific PKC inhibitor GF 109203X or by down regulation of phorbol ester-sensitive PKC isoforms. In addition, bombesin rapidly stimulated p74raf-1 activity that was also independent of PKC activity and insensitive to inhibition by pertussis toxin. Furthermore, addition of neuromedin B to Rat-1 cells transfected with the neuromedin B preferring receptor also activated p42mapk and p74raf-1 in a PKC-independent and pertussis toxin-insensitive manner. Finally we show that addition of bombesin to Rat-1 cells stimulated the GTP loading of p21ras. Our results reveal a novel PKC-independent pathway in the action of Gq-coupled receptors and stress the importance of cell context in defining the signal transduction pathway(s) that link specific receptors to the activation of the mitogen-activated protein kinase cascade." @default.
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- W2313714319 date "1997-05-15" @default.
- W2313714319 modified "2023-09-25" @default.
- W2313714319 title "Bombesin and neuromedin B stimulate the activation of p42mapk and p74raf-1 via a protein kinase C-independent pathway in Rat-1 cells" @default.
- W2313714319 doi "https://doi.org/10.1038/sj.onc.1201075" @default.
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