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- W2313739907 abstract "Objective: To evaluate antioxidant, analgesic and anti-inflammatory properties of embelin and its derivatives. Methods: In the present study embelin was condensed with various aliphatic substituted primary amines, hydrazines and amino acids to yield seven new and five reported derivatives. All these compounds along with embelin were evaluated for in vitro antioxidant activity using ABTS and DPPH methods. Potent compounds were selected for in vivo analgesic and anti-inflammatory activities. Results: Hydrazines, amino acids substituted embelin derivatives and phenazines showed potent antioxidant activity. These compounds along with embelin were studied for analgesic and anti-inflammatory activities at 10 and 20 mg/kg doses by standard methods. Potent analgesic activity higher than the standard pentazocine was observed. Embelin and its derivatives almost completely abolished the acetic acid induced writhing. Phenyl alanine and phenazine derivative showed better anti-inflammatory activity than embelin. Conclusion: Further research would be of interest to explain the exact mechanism of these compounds and chemical modifications, biological screening and toxicity studies can also be explored." @default.
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- W2313739907 date "2014-01-10" @default.
- W2313739907 modified "2023-09-28" @default.
- W2313739907 title "Synthesis and Evaluation of Analgesic and Anti-inflammatory Activities of Most Active Antioxidant Derivatives of Embelin" @default.
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- W2313739907 doi "https://doi.org/10.9734/bjpr/2014/12708" @default.
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