FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313757943> ?p ?o ?g. }

• W2313757943 endingPage "336" @default.
• W2313757943 startingPage "328" @default.
• W2313757943 abstract "The cerebral blood volume (CBV) is sensitive to changing hydrostatic pressures. Thus, measurement methods that rely on removing tissue from unfixed brain may lead to underestimates of the CBV due to the loss of blood from the tissue. In situ fixation of tissue before removal may offer improved accuracy. We employed a triple-label method to measure simultaneously whole brain CBF and CBV in halothane-anesthetized Sprague–Dawley rats, which were then killed either by focused microwave irradiation (≈8 kW of incident power × 770 ms) or by decapitation. CBF was measured with [ 3 H]nicotine while the CBV was determined as the sum of the cerebral red cell volume (CRCV—measured with 99m Tc-labeled red cells) and the cerebral plasma volume (CPV—measured with [ 14 C]dextran). Animals were studied during hypocarbic (P a co 2 ≈ 25 mm Hg), normocarbic, or hypercarbic (P a co 2 ≈ 70 mm Hg) conditions. Added studies were performed to verify that the microwave irradiation scheme used was capable of fixing previously administered tracers in place, and also halting the entry of tracer given after irradiation. Results indicate that the method of killing had no effects on CBF measurements, as assessed either by absolute values during normocarbia or responsiveness to changing P a co 2 . However, all three volume measurements made using nondiffusible tracers (CRCV, CPV, and CBV) were significantly lower in animals killed by decapitation. Furthermore, CO 2 responsiveness for all three variables (as assessed by the slope of the P a co 2 /volume) was not evident in decapitated animals. We conclude that in situ fixation offers significant advantages when examining the cerebral distribution space of nondiffusible tracers." @default.
• W2313757943 created "2016-06-24" @default.
• W2313757943 creator A5020070598 @default.
• W2313757943 creator A5036105947 @default.
• W2313757943 creator A5050506489 @default.
• W2313757943 date "1993-03-01" @default.
• W2313757943 modified "2023-09-25" @default.
• W2313757943 title "Microwave Fixation for the Determination of Cerebral Blood Volume in Rats" @default.
• W2313757943 cites W1815610057 @default.
• W2313757943 cites W1966458197 @default.
• W2313757943 cites W1968933230 @default.
• W2313757943 cites W1972303595 @default.
• W2313757943 cites W1981670300 @default.
• W2313757943 cites W1985500693 @default.
• W2313757943 cites W1992021116 @default.
• W2313757943 cites W1998865625 @default.
• W2313757943 cites W2006264633 @default.
• W2313757943 cites W2007105529 @default.
• W2313757943 cites W2008980426 @default.
• W2313757943 cites W2010047149 @default.
• W2313757943 cites W2022784058 @default.
• W2313757943 cites W2022944702 @default.
• W2313757943 cites W2023537722 @default.
• W2313757943 cites W2025131113 @default.
• W2313757943 cites W2028758897 @default.
• W2313757943 cites W2038862011 @default.
• W2313757943 cites W2049502359 @default.
• W2313757943 cites W2058012218 @default.
• W2313757943 cites W2060906896 @default.
• W2313757943 cites W2071360157 @default.
• W2313757943 cites W2074949491 @default.
• W2313757943 cites W2086337219 @default.
• W2313757943 cites W2087529264 @default.
• W2313757943 cites W2091227588 @default.
• W2313757943 cites W2117303077 @default.
• W2313757943 cites W2124913096 @default.
• W2313757943 cites W2153521419 @default.
• W2313757943 cites W2162637508 @default.
• W2313757943 cites W2202838604 @default.
• W2313757943 cites W2410646478 @default.
• W2313757943 doi "https://doi.org/10.1038/jcbfm.1993.41" @default.
• W2313757943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8436626" @default.
• W2313757943 hasPublicationYear "1993" @default.
• W2313757943 type Work @default.
• W2313757943 sameAs 2313757943 @default.
• W2313757943 citedByCount "43" @default.
• W2313757943 countsByYear W23137579432017 @default.
• W2313757943 countsByYear W23137579432019 @default.
• W2313757943 countsByYear W23137579432020 @default.
• W2313757943 countsByYear W23137579432021 @default.
• W2313757943 crossrefType "journal-article" @default.
• W2313757943 hasAuthorship W2313757943A5020070598 @default.
• W2313757943 hasAuthorship W2313757943A5036105947 @default.
• W2313757943 hasAuthorship W2313757943A5050506489 @default.
• W2313757943 hasConcept C104317684 @default.
• W2313757943 hasConcept C126322002 @default.
• W2313757943 hasConcept C136229726 @default.
• W2313757943 hasConcept C146249460 @default.
• W2313757943 hasConcept C157767197 @default.
• W2313757943 hasConcept C185592680 @default.
• W2313757943 hasConcept C2982720008 @default.
• W2313757943 hasConcept C2986936838 @default.
• W2313757943 hasConcept C2989005 @default.
• W2313757943 hasConcept C2991747820 @default.
• W2313757943 hasConcept C37557685 @default.
• W2313757943 hasConcept C42219234 @default.
• W2313757943 hasConcept C55493867 @default.
• W2313757943 hasConcept C71924100 @default.
• W2313757943 hasConceptScore W2313757943C104317684 @default.
• W2313757943 hasConceptScore W2313757943C126322002 @default.
• W2313757943 hasConceptScore W2313757943C136229726 @default.
• W2313757943 hasConceptScore W2313757943C146249460 @default.
• W2313757943 hasConceptScore W2313757943C157767197 @default.
• W2313757943 hasConceptScore W2313757943C185592680 @default.
• W2313757943 hasConceptScore W2313757943C2982720008 @default.
• W2313757943 hasConceptScore W2313757943C2986936838 @default.
• W2313757943 hasConceptScore W2313757943C2989005 @default.
• W2313757943 hasConceptScore W2313757943C2991747820 @default.
• W2313757943 hasConceptScore W2313757943C37557685 @default.
• W2313757943 hasConceptScore W2313757943C42219234 @default.
• W2313757943 hasConceptScore W2313757943C55493867 @default.
• W2313757943 hasConceptScore W2313757943C71924100 @default.
• W2313757943 hasIssue "2" @default.
• W2313757943 hasLocation W23137579431 @default.
• W2313757943 hasLocation W23137579432 @default.
• W2313757943 hasOpenAccess W2313757943 @default.
• W2313757943 hasPrimaryLocation W23137579431 @default.
• W2313757943 hasRelatedWork W2020383693 @default.
• W2313757943 hasRelatedWork W203210588 @default.
• W2313757943 hasRelatedWork W2037951020 @default.
• W2313757943 hasRelatedWork W2049282924 @default.
• W2313757943 hasRelatedWork W2060318115 @default.
• W2313757943 hasRelatedWork W2140464965 @default.
• W2313757943 hasRelatedWork W2164643454 @default.
• W2313757943 hasRelatedWork W2362707697 @default.
• W2313757943 hasRelatedWork W2413992441 @default.
• W2313757943 hasRelatedWork W3032616145 @default.
• W2313757943 hasVolume "13" @default.

• next