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• W2313761799 abstract "Fractionation of an ethanol-soluble extract of the seeds of Swietenia macrophylla yielded six new limonoids, swielimonoids A–F (1–6), along with 20 known compounds. Compounds 1 and 2, mexicanolide-type limonoids, were assigned with an α,β-unsaturated δ-lactone moiety (ring D) and a C═C bond between C-8 and C-30. Compounds 3–6 could be categorized as highly oxygenated phragmalin-type limonoids. The structures of these new compounds were elucidated through the interpretation of spectroscopic data. The antidengue virus 2 activities of the isolated components from S. macrophylla were investigated, and of 12 compounds subjected to bioassay, compounds 2 and 7–10 were found to show inhibitory activity in the range 3.5 to 12.5 μM. Among these, the new limonoid 2 exhibited significant antiviral activity (EC50 = 7.2 ± 1.33 μM) with a selectivity index (CC50/EC50) value of >27.7." @default.
• W2313761799 created "2016-06-24" @default.
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• W2313761799 date "2014-10-20" @default.
• W2313761799 modified "2023-10-14" @default.
• W2313761799 title "Limonoids from the Seeds of <i>Swietenia macrophylla</i> with Inhibitory Activity against Dengue Virus 2" @default.
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• W2313761799 doi "https://doi.org/10.1021/np5002829" @default.
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