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- W2313770147 abstract "Biotransformation studies conducted on (+)-(S)-ar-turmerone (1) and (+)-(S)-dihydro-ar-turmerone (2) by the fungus Aspergillus niger have revealed that 1 was metabolized to give four oxidized metabolites, (+)-(7S)-hydroxydehydro-ar-todomatuic acid (3), (+)-(7S,10E)-12-hydroxydehydro-ar-todomatuic acid (4), (+)-(7S,10E)-7,12-dihydroxydehydro-ar-todomatuic acid (5), and (+)-(7S)-15-carboxy-9,13-epoxy-7-hydroxy-9,13-dehydro-ar-curcumene (6), and (+)-(S)-dihydro-ar-turmerone (2) was metabolized to (+)-7,11-dihydroxy-ar-todomatuic acid (7). Metabolites 3−7 were characterized using spectroscopic techniques. Metabolites 3−7 inhibited acetylcholinesterase (AChE) although less so than the parent substrates." @default.
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- W2313770147 date "2010-12-28" @default.
- W2313770147 modified "2023-09-27" @default.
- W2313770147 title "Biotransformation of Turmerones by <i>Aspergillus niger</i>" @default.
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- W2313770147 doi "https://doi.org/10.1021/np100416v" @default.
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