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- W2313778892 abstract "Background: Preclinical evidence suggests that commonly used anesthetic agents induce long-lasting neurobehavioral changes when administered early in life, but there has been virtually no attention to the neurodevelopmental consequences forthefetusofmaternalanesthesia.Thisstudytestedthehypothesis that fetal rats exposed to isoflurane during maternal anesthesia on gestational day 14, which corresponds to the second trimester in humans, would be behaviorally abnormal as adults. Methods: Timed, pregnant rats were randomly assigned on gestationalday14toreceive1.4%isofluranein100%oxygen (n 3) or 100% oxygen (n 2) for 4 h. Beginning at 8 weeks of age, male offspring (N 12–14 in control and anesthesia groups, respectively) were evaluated for spontaneous locomotor activity, hippocampal-dependent learning and memory (i.e., spontaneous alternations, novel object recognition, and radial arm maze), and anxiety (elevated plus maze). Results: Isoflurane anesthesia was physiologically well tolerated by the dams. Adult rats exposed prenatally to isoflurane were not different than controls on spontaneous locomotor activity, spontaneous alternations, or object recognition memory, but made more open arm entries on the elevated plusmazeandtooklongerandmademoreerrorsofomission on the radial arm maze. Conclusions: Rats exposed to isoflurane in utero at a time that corresponds to the second trimester in humans have impaired spatial memory acquisition and reduced anxiety, compared with controls. This suggests the fetal brain may be adversely affected by maternal anesthesia, and raises the possibility that vulnerability to deleterious neurodevelopmental effects of isoflurane begins much earlier in life than previously recognized." @default.
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- W2313778892 date "2011-12-01" @default.
- W2313778892 modified "2023-09-30" @default.
- W2313778892 title "Rats Exposed to Isoflurane in Utero During Early Gestation Are Behaviorally Abnormal as Adults" @default.
- W2313778892 doi "https://doi.org/10.1097/01.aoa.0000406677.24906.42" @default.
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