Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313781640> ?p ?o ?g. }
- W2313781640 endingPage "307" @default.
- W2313781640 startingPage "300" @default.
- W2313781640 abstract "There are many ongoing clinical trials to validate tumour microenvironment or autophagic pathway components as targets for anticancer therapies. Different components of the tumour microenvironment play important roles in tumour cell responses, directly affecting malignant transformation, drug resistance and metastasis. Autophagy is also related to chemotherapy responses by inducing tumour cell death or survival. Thus, the autophagy pathway may act as oncosuppressor, in addition to protecting cells from chemotherapy. The cross-talk between the microenvironment and autophagy is very complex and poorly understood. In a recent study using a three-dimensional (3D) cell culture model, the well-documented chemotherapy-mediated activation of autophagy was impaired in breast cancer cells, suggesting a context-dependent outcome for autophagy modulators, under the control of the p53 protein. A deeper understanding of this microenvironment/autophagy interplay may provide important clues for identifying differences in the tumour cell signalling network from in vitro basic research studies to the actual clinical context. In this work, we summarize the role of the microenvironment and autophagy in physiological and tumourigenic conditions, their interactions, and the challenges related to the use of drugs that target these pathways in cancer treatment protocols, emphasizing the potential use of 3D cell culture models in preclinical studies." @default.
- W2313781640 created "2016-06-24" @default.
- W2313781640 creator A5006395053 @default.
- W2313781640 creator A5044797294 @default.
- W2313781640 creator A5079483159 @default.
- W2313781640 date "2016-05-01" @default.
- W2313781640 modified "2023-09-27" @default.
- W2313781640 title "Microenvironment and autophagy cross-talk: Implications in cancer therapy" @default.
- W2313781640 cites W119020121 @default.
- W2313781640 cites W170874625 @default.
- W2313781640 cites W1784425676 @default.
- W2313781640 cites W1863425168 @default.
- W2313781640 cites W1963547612 @default.
- W2313781640 cites W1965037168 @default.
- W2313781640 cites W1966179301 @default.
- W2313781640 cites W1972582451 @default.
- W2313781640 cites W1972825083 @default.
- W2313781640 cites W1978818883 @default.
- W2313781640 cites W1983594330 @default.
- W2313781640 cites W1985061144 @default.
- W2313781640 cites W1988654808 @default.
- W2313781640 cites W1989821468 @default.
- W2313781640 cites W1990619980 @default.
- W2313781640 cites W1997216820 @default.
- W2313781640 cites W1999093552 @default.
- W2313781640 cites W2003047743 @default.
- W2313781640 cites W2004125175 @default.
- W2313781640 cites W2004325124 @default.
- W2313781640 cites W2005117785 @default.
- W2313781640 cites W2005463129 @default.
- W2313781640 cites W2006628284 @default.
- W2313781640 cites W2009183786 @default.
- W2313781640 cites W2016431888 @default.
- W2313781640 cites W2016725226 @default.
- W2313781640 cites W2017855147 @default.
- W2313781640 cites W2019576484 @default.
- W2313781640 cites W2020112232 @default.
- W2313781640 cites W2033278321 @default.
- W2313781640 cites W2033415182 @default.
- W2313781640 cites W2034339677 @default.
- W2313781640 cites W2037345852 @default.
- W2313781640 cites W2039403501 @default.
- W2313781640 cites W2039607936 @default.
- W2313781640 cites W2041255615 @default.
- W2313781640 cites W2041636145 @default.
- W2313781640 cites W2041759782 @default.
- W2313781640 cites W2043803160 @default.
- W2313781640 cites W2045122835 @default.
- W2313781640 cites W2047390792 @default.
- W2313781640 cites W2050331453 @default.
- W2313781640 cites W2050547186 @default.
- W2313781640 cites W2052077889 @default.
- W2313781640 cites W2059388879 @default.
- W2313781640 cites W2065515174 @default.
- W2313781640 cites W2066800765 @default.
- W2313781640 cites W2066964642 @default.
- W2313781640 cites W2078893058 @default.
- W2313781640 cites W2079351077 @default.
- W2313781640 cites W2082229119 @default.
- W2313781640 cites W2082639976 @default.
- W2313781640 cites W2085442981 @default.
- W2313781640 cites W2091940240 @default.
- W2313781640 cites W2092321143 @default.
- W2313781640 cites W2093048712 @default.
- W2313781640 cites W2094156804 @default.
- W2313781640 cites W2095294326 @default.
- W2313781640 cites W2095554214 @default.
- W2313781640 cites W2099225188 @default.
- W2313781640 cites W2100312975 @default.
- W2313781640 cites W2100568496 @default.
- W2313781640 cites W2106255061 @default.
- W2313781640 cites W2109438520 @default.
- W2313781640 cites W2110025151 @default.
- W2313781640 cites W2114038645 @default.
- W2313781640 cites W2115928549 @default.
- W2313781640 cites W2116836791 @default.
- W2313781640 cites W2117692326 @default.
- W2313781640 cites W2117726975 @default.
- W2313781640 cites W2118834593 @default.
- W2313781640 cites W2121780059 @default.
- W2313781640 cites W2122212799 @default.
- W2313781640 cites W2124351032 @default.
- W2313781640 cites W2127362646 @default.
- W2313781640 cites W2128049766 @default.
- W2313781640 cites W2129211163 @default.
- W2313781640 cites W2132566055 @default.
- W2313781640 cites W2132655645 @default.
- W2313781640 cites W2132966617 @default.
- W2313781640 cites W2133000461 @default.
- W2313781640 cites W2134414272 @default.
- W2313781640 cites W2135571525 @default.
- W2313781640 cites W2135870265 @default.
- W2313781640 cites W2136053113 @default.
- W2313781640 cites W2136331786 @default.
- W2313781640 cites W2140912399 @default.
- W2313781640 cites W2142845200 @default.
- W2313781640 cites W2147000598 @default.
- W2313781640 cites W2148281700 @default.