FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313806937> ?p ?o ?g. }

• W2313806937 abstract "Background BI-RADS Category 4 patients have a 2–95% risk for malignancy and are generally recommended for breast biopsy with little discrimination for risk level or distinction between risk of invasive or in situ disease. Our study sought to determine if higher thresholds for biopsy based on stratifying for risk and distinguishing between risk of invasive cancer and DCIS could reduce biopsy rates and increase cancer-to-biopsy yields without missing cancers urgent for resolution. Methods 108 BI-RADS 4 cases with final outcomes data were evaluated from a prospective cohort of 215 consecutive patients seen at a same-day multidisciplinary breast clinic for women with mammograms categorized as BI-RADS 0, 4, or 5 in 2006–07. Final outcomes were determined from pathologic diagnosis or two-year follow-up. Risk estimates (RE) for DCIS and invasive cancer were collected prospectively and re-assessed by a radiologist blinded to outcomes and prior reading assessments. Cases were stratified according to the risk ranges of the BI-RADS 4 subcategories and risk of invasive or in situ disease. Biopsy rates, cancer-to-biopsy yields, and number of malignancies missed were calculated for various thresholds for intervention. Results A ROC curve for invasive cancer risk for the radiologist demonstrated a 98.5% level of accuracy (95% confidence interval [CI]: 96.9%, 100%). 60 cases had some risk for invasive cancer and 48 had some risk for DCIS. There were 14 invasive cancer and 11 DCIS outcomes, 3 of which were high-grade. Pathologic assessment from biopsy or surgery was available for 100 patients. The outcomes of 8 cases were determined by benign two-year follow-up. There are several strategies for intervention that improve biopsy yield and reduce biopsies for benign disease as shown in Table 1. If cases with RE between 2–10% for DCIS or invasive cancer were not biopsied, 23% of biopsies would be avoided and the yield would increase to 30%. If cases with invasive cancer RE between 10–95% and DCIS RE between 50–95% were biopsied, 52% of biopsies would be avoided and the yield would increase to 39%. One invasive ductal carcinoma (3 mm, Grade 2) would be missed, although with six-month follow-up, this would not be a problem. Limitations Small sample size; one radiologist providing RE may not be representative of general mammographic assessment. Conclusion Setting higher biopsy thresholds for BI-RADS 4 lesions can safely reduce biopsy rates and increase biopsy yields. Given evidence suggesting that low/intermediate grade DCIS may be overdiagnosed, distinguishing between DCIS and invasive cancer risk at screening by offering active surveillance as an alternative to biopsy for BI-RADS 4 lesions suspicious for non-high-grade DCIS may be a promising approach for reducing biopsies. This will be prospectively tested in a reader study using several radiology readers in a series of 750 cases in the Athena Breast Health Network. New biopsy thresholds can be set if the results of our study can be validated. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-09-02." @default.
• W2313806937 created "2016-06-24" @default.
• W2313806937 creator A5012722503 @default.
• W2313806937 creator A5051432576 @default.
• W2313806937 creator A5054162140 @default.
• W2313806937 creator A5065951277 @default.
• W2313806937 creator A5075105749 @default.
• W2313806937 creator A5085174655 @default.
• W2313806937 date "2011-12-15" @default.
• W2313806937 modified "2023-09-26" @default.
• W2313806937 title "P5-09-02: Reducing Excess Biopsies: Improving Screening through Risk Stratification and New Thresholds for Intervention." @default.
• W2313806937 doi "https://doi.org/10.1158/0008-5472.sabcs11-p5-09-02" @default.
• W2313806937 hasPublicationYear "2011" @default.
• W2313806937 type Work @default.
• W2313806937 sameAs 2313806937 @default.
• W2313806937 citedByCount "0" @default.
• W2313806937 crossrefType "proceedings-article" @default.
• W2313806937 hasAuthorship W2313806937A5012722503 @default.
• W2313806937 hasAuthorship W2313806937A5051432576 @default.
• W2313806937 hasAuthorship W2313806937A5054162140 @default.
• W2313806937 hasAuthorship W2313806937A5065951277 @default.
• W2313806937 hasAuthorship W2313806937A5075105749 @default.
• W2313806937 hasAuthorship W2313806937A5085174655 @default.
• W2313806937 hasConcept C121608353 @default.
• W2313806937 hasConcept C12174686 @default.
• W2313806937 hasConcept C126322002 @default.
• W2313806937 hasConcept C126838900 @default.
• W2313806937 hasConcept C188816634 @default.
• W2313806937 hasConcept C2775934546 @default.
• W2313806937 hasConcept C2777517664 @default.
• W2313806937 hasConcept C2779399171 @default.
• W2313806937 hasConcept C2780472235 @default.
• W2313806937 hasConcept C3020404979 @default.
• W2313806937 hasConcept C38652104 @default.
• W2313806937 hasConcept C41008148 @default.
• W2313806937 hasConcept C44249647 @default.
• W2313806937 hasConcept C530470458 @default.
• W2313806937 hasConcept C71924100 @default.
• W2313806937 hasConcept C72563966 @default.
• W2313806937 hasConceptScore W2313806937C121608353 @default.
• W2313806937 hasConceptScore W2313806937C12174686 @default.
• W2313806937 hasConceptScore W2313806937C126322002 @default.
• W2313806937 hasConceptScore W2313806937C126838900 @default.
• W2313806937 hasConceptScore W2313806937C188816634 @default.
• W2313806937 hasConceptScore W2313806937C2775934546 @default.
• W2313806937 hasConceptScore W2313806937C2777517664 @default.
• W2313806937 hasConceptScore W2313806937C2779399171 @default.
• W2313806937 hasConceptScore W2313806937C2780472235 @default.
• W2313806937 hasConceptScore W2313806937C3020404979 @default.
• W2313806937 hasConceptScore W2313806937C38652104 @default.
• W2313806937 hasConceptScore W2313806937C41008148 @default.
• W2313806937 hasConceptScore W2313806937C44249647 @default.
• W2313806937 hasConceptScore W2313806937C530470458 @default.
• W2313806937 hasConceptScore W2313806937C71924100 @default.
• W2313806937 hasConceptScore W2313806937C72563966 @default.
• W2313806937 hasLocation W23138069371 @default.
• W2313806937 hasOpenAccess W2313806937 @default.
• W2313806937 hasPrimaryLocation W23138069371 @default.
• W2313806937 hasRelatedWork W1618174651 @default.
• W2313806937 hasRelatedWork W2040395400 @default.
• W2313806937 hasRelatedWork W2049890072 @default.
• W2313806937 hasRelatedWork W2071726232 @default.
• W2313806937 hasRelatedWork W2120668961 @default.
• W2313806937 hasRelatedWork W2313593745 @default.
• W2313806937 hasRelatedWork W2314950916 @default.
• W2313806937 hasRelatedWork W2329155139 @default.
• W2313806937 hasRelatedWork W2329661224 @default.
• W2313806937 hasRelatedWork W2335622731 @default.
• W2313806937 hasRelatedWork W2509104826 @default.
• W2313806937 hasRelatedWork W2521151067 @default.
• W2313806937 hasRelatedWork W2605568489 @default.
• W2313806937 hasRelatedWork W2785906812 @default.
• W2313806937 hasRelatedWork W2897036123 @default.
• W2313806937 hasRelatedWork W2964603785 @default.
• W2313806937 hasRelatedWork W2979231788 @default.
• W2313806937 hasRelatedWork W3001322414 @default.
• W2313806937 hasRelatedWork W3125605517 @default.
• W2313806937 hasRelatedWork W2294914981 @default.
• W2313806937 isParatext "false" @default.
• W2313806937 isRetracted "false" @default.
• W2313806937 magId "2313806937" @default.
• W2313806937 workType "article" @default.