Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313821840> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2313821840 endingPage "730e" @default.
- W2313821840 startingPage "720e" @default.
- W2313821840 abstract "Background: Vascularized composite allotransplantation has become a clinical reality. Patients undergoing vascularized composite allotransplantation have modest functional return. Most patients have had multiple acute rejections. The effect of multiple acute rejections influencing functional outcomes is unknown. This study systematically analyzes the effects of multiple acute rejections on functional outcome. Methods: Rat functional orthotopic hind-limb transplants were performed from Brown-Norway to Lewis rats. Group 1 consisted of isografts. In group 2, daily cyclosporine was administered to prevent acute rejection. In group 3, recipients did not receive regular immunosuppression but received only pulsed cyclosporine and dexamethasone to rescue acute rejection. The study endpoint was 90 days. Muscle and sciatic nerve biopsy specimens were taken for histologic analyses. Hind-limb function was assessed using sciatic nerve axon density, nerve conduction velocity, and muscle force generated by the gastrocnemius muscle. Novel video kinematics was used to analyze gait. Results: By the endpoint, group 3 animals had 17 ± 5.1 acute rejections. Muscle biopsy showed significant atrophy and fibrosis in group 3 compared with groups 1 and 2. Withdrawal to pin prick was evident by days 31 ± 1.2, 30 ± 2.3, and 31 ± 3.7 in groups 1, 2, and 3, respectively. At the endpoint, there was no significant difference in the axon density or nerve conduction velocity among the three groups, but muscle force generated was significantly less in group 3. Gait was abnormal in group 3 animals compared with other groups. Conclusions: In this study, multiple acute rejections induced muscle atrophy and fibrosis and consequent decreased function. This emphasizes the importance of preventing acute rejection to achieve optimum function following vascularized composite allotransplantation." @default.
- W2313821840 created "2016-06-24" @default.
- W2313821840 creator A5003825398 @default.
- W2313821840 creator A5020600016 @default.
- W2313821840 creator A5024911410 @default.
- W2313821840 creator A5031747746 @default.
- W2313821840 creator A5047110309 @default.
- W2313821840 creator A5051347336 @default.
- W2313821840 creator A5054605529 @default.
- W2313821840 creator A5070895861 @default.
- W2313821840 date "2013-05-01" @default.
- W2313821840 modified "2023-10-01" @default.
- W2313821840 title "Functional Outcomes following Multiple Acute Rejections in Experimental Vascularized Composite Allotransplantation" @default.
- W2313821840 cites W1600221749 @default.
- W2313821840 cites W1983491684 @default.
- W2313821840 cites W1991018296 @default.
- W2313821840 cites W2009731830 @default.
- W2313821840 cites W2022756809 @default.
- W2313821840 cites W2046869627 @default.
- W2313821840 cites W2048310638 @default.
- W2313821840 cites W2069911637 @default.
- W2313821840 cites W2077923788 @default.
- W2313821840 cites W2142183427 @default.
- W2313821840 cites W2149771053 @default.
- W2313821840 cites W2160582502 @default.
- W2313821840 cites W2325463633 @default.
- W2313821840 cites W4250587277 @default.
- W2313821840 doi "https://doi.org/10.1097/prs.0b013e3182879e85" @default.
- W2313821840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23629111" @default.
- W2313821840 hasPublicationYear "2013" @default.
- W2313821840 type Work @default.
- W2313821840 sameAs 2313821840 @default.
- W2313821840 citedByCount "12" @default.
- W2313821840 countsByYear W23138218402013 @default.
- W2313821840 countsByYear W23138218402015 @default.
- W2313821840 countsByYear W23138218402016 @default.
- W2313821840 countsByYear W23138218402017 @default.
- W2313821840 countsByYear W23138218402020 @default.
- W2313821840 countsByYear W23138218402021 @default.
- W2313821840 countsByYear W23138218402022 @default.
- W2313821840 crossrefType "journal-article" @default.
- W2313821840 hasAuthorship W2313821840A5003825398 @default.
- W2313821840 hasAuthorship W2313821840A5020600016 @default.
- W2313821840 hasAuthorship W2313821840A5024911410 @default.
- W2313821840 hasAuthorship W2313821840A5031747746 @default.
- W2313821840 hasAuthorship W2313821840A5047110309 @default.
- W2313821840 hasAuthorship W2313821840A5051347336 @default.
- W2313821840 hasAuthorship W2313821840A5054605529 @default.
- W2313821840 hasAuthorship W2313821840A5070895861 @default.
- W2313821840 hasConcept C105702510 @default.
- W2313821840 hasConcept C126322002 @default.
- W2313821840 hasConcept C126894567 @default.
- W2313821840 hasConcept C141071460 @default.
- W2313821840 hasConcept C179253579 @default.
- W2313821840 hasConcept C2775934546 @default.
- W2313821840 hasConcept C2776263037 @default.
- W2313821840 hasConcept C2777561873 @default.
- W2313821840 hasConcept C2779530196 @default.
- W2313821840 hasConcept C2780252810 @default.
- W2313821840 hasConcept C2780559512 @default.
- W2313821840 hasConcept C2781172350 @default.
- W2313821840 hasConcept C2911091166 @default.
- W2313821840 hasConcept C42219234 @default.
- W2313821840 hasConcept C71924100 @default.
- W2313821840 hasConceptScore W2313821840C105702510 @default.
- W2313821840 hasConceptScore W2313821840C126322002 @default.
- W2313821840 hasConceptScore W2313821840C126894567 @default.
- W2313821840 hasConceptScore W2313821840C141071460 @default.
- W2313821840 hasConceptScore W2313821840C179253579 @default.
- W2313821840 hasConceptScore W2313821840C2775934546 @default.
- W2313821840 hasConceptScore W2313821840C2776263037 @default.
- W2313821840 hasConceptScore W2313821840C2777561873 @default.
- W2313821840 hasConceptScore W2313821840C2779530196 @default.
- W2313821840 hasConceptScore W2313821840C2780252810 @default.
- W2313821840 hasConceptScore W2313821840C2780559512 @default.
- W2313821840 hasConceptScore W2313821840C2781172350 @default.
- W2313821840 hasConceptScore W2313821840C2911091166 @default.
- W2313821840 hasConceptScore W2313821840C42219234 @default.
- W2313821840 hasConceptScore W2313821840C71924100 @default.
- W2313821840 hasIssue "5" @default.
- W2313821840 hasLocation W23138218401 @default.
- W2313821840 hasOpenAccess W2313821840 @default.
- W2313821840 hasPrimaryLocation W23138218401 @default.
- W2313821840 hasRelatedWork W1968022584 @default.
- W2313821840 hasRelatedWork W2028875463 @default.
- W2313821840 hasRelatedWork W2045244606 @default.
- W2313821840 hasRelatedWork W2052063382 @default.
- W2313821840 hasRelatedWork W2084272222 @default.
- W2313821840 hasRelatedWork W2116100577 @default.
- W2313821840 hasRelatedWork W2134770808 @default.
- W2313821840 hasRelatedWork W2358939561 @default.
- W2313821840 hasRelatedWork W2507361224 @default.
- W2313821840 hasRelatedWork W3214058578 @default.
- W2313821840 hasVolume "131" @default.
- W2313821840 isParatext "false" @default.
- W2313821840 isRetracted "false" @default.
- W2313821840 magId "2313821840" @default.
- W2313821840 workType "article" @default.