Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313831712> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2313831712 abstract "Quick emergence of drug resistant phenotypes of Plasmodium falciparum against new anti-malarial drugs have been a serious problem in the clinical field fighting malaria. Since no effective malaria vaccine is available, transmission-blocking targeting gametocyte and gemtocytegenesis may be an excellent alternative approach. Gamtocyte parasite exhibits lower sensitivity against currently available anti-malarial drugs and characteristic biology that is quite different from that in asexual intraerythrocytic stages. However, our understanding gametocyte biology is still premature for leading an effective transmission-blocking drug to stop parasites moving to mosquito stages. In this study, we focused on lipid metabolism, particularly lipid accumulation and recycling of the lipid storage. With fluorescence microscopy study, gametocyte showed marked increases in the total lipid amount as well as lipid droplets in parasite cytoplasm while no significant increase in cholesterol, demonstrating a unique lipid environment is developed inside parasite. However, hyperspectral imaging showed most of hemoglobin molecules were consumed during gemetocytegenesis indicating its correlation with lipid productions and accumulations. Gametocytes are taken by mosquito and continue active stages where high amount of energy must be supplied. Therefore, we hypothesized that accumulated lipids will be recycled through gluconeogenesis consuming triacylglycerides (TAG) as a supplemental energy source to obtain dihydroacetonephosphate that is involved in the normal glycolysis. We used high-sensitivity LC/MS and quantified relative amount ratio of TAG and glycerol, an intermediate product in gluconeogenesis, to compare between asexual and gametocyte stages." @default.
- W2313831712 created "2016-06-24" @default.
- W2313831712 creator A5027161141 @default.
- W2313831712 creator A5050403450 @default.
- W2313831712 creator A5061064714 @default.
- W2313831712 creator A5072986768 @default.
- W2313831712 creator A5073324717 @default.
- W2313831712 creator A5090805940 @default.
- W2313831712 date "2015-01-01" @default.
- W2313831712 modified "2023-10-02" @default.
- W2313831712 title "Accumulations and Energy Recycling Pathway in P. Falciparum Gametocyte-Infected Human Erythrocytes" @default.
- W2313831712 doi "https://doi.org/10.1016/j.bpj.2014.11.3339" @default.
- W2313831712 hasPublicationYear "2015" @default.
- W2313831712 type Work @default.
- W2313831712 sameAs 2313831712 @default.
- W2313831712 citedByCount "0" @default.
- W2313831712 crossrefType "journal-article" @default.
- W2313831712 hasAuthorship W2313831712A5027161141 @default.
- W2313831712 hasAuthorship W2313831712A5050403450 @default.
- W2313831712 hasAuthorship W2313831712A5061064714 @default.
- W2313831712 hasAuthorship W2313831712A5072986768 @default.
- W2313831712 hasAuthorship W2313831712A5073324717 @default.
- W2313831712 hasAuthorship W2313831712A5090805940 @default.
- W2313831712 hasBestOaLocation W23138317121 @default.
- W2313831712 hasConcept C136764020 @default.
- W2313831712 hasConcept C20251656 @default.
- W2313831712 hasConcept C203014093 @default.
- W2313831712 hasConcept C25095133 @default.
- W2313831712 hasConcept C2778048844 @default.
- W2313831712 hasConcept C2778371730 @default.
- W2313831712 hasConcept C2778675580 @default.
- W2313831712 hasConcept C41008148 @default.
- W2313831712 hasConcept C4733338 @default.
- W2313831712 hasConcept C55493867 @default.
- W2313831712 hasConcept C62231903 @default.
- W2313831712 hasConcept C71928629 @default.
- W2313831712 hasConcept C86803240 @default.
- W2313831712 hasConcept C99389464 @default.
- W2313831712 hasConceptScore W2313831712C136764020 @default.
- W2313831712 hasConceptScore W2313831712C20251656 @default.
- W2313831712 hasConceptScore W2313831712C203014093 @default.
- W2313831712 hasConceptScore W2313831712C25095133 @default.
- W2313831712 hasConceptScore W2313831712C2778048844 @default.
- W2313831712 hasConceptScore W2313831712C2778371730 @default.
- W2313831712 hasConceptScore W2313831712C2778675580 @default.
- W2313831712 hasConceptScore W2313831712C41008148 @default.
- W2313831712 hasConceptScore W2313831712C4733338 @default.
- W2313831712 hasConceptScore W2313831712C55493867 @default.
- W2313831712 hasConceptScore W2313831712C62231903 @default.
- W2313831712 hasConceptScore W2313831712C71928629 @default.
- W2313831712 hasConceptScore W2313831712C86803240 @default.
- W2313831712 hasConceptScore W2313831712C99389464 @default.
- W2313831712 hasLocation W23138317121 @default.
- W2313831712 hasOpenAccess W2313831712 @default.
- W2313831712 hasPrimaryLocation W23138317121 @default.
- W2313831712 hasRelatedWork W105246958 @default.
- W2313831712 hasRelatedWork W1576714964 @default.
- W2313831712 hasRelatedWork W1576735252 @default.
- W2313831712 hasRelatedWork W1812017132 @default.
- W2313831712 hasRelatedWork W2112076496 @default.
- W2313831712 hasRelatedWork W2170680268 @default.
- W2313831712 hasRelatedWork W2468867624 @default.
- W2313831712 hasRelatedWork W2765581562 @default.
- W2313831712 hasRelatedWork W2806163416 @default.
- W2313831712 hasRelatedWork W290159271 @default.
- W2313831712 hasRelatedWork W2938100698 @default.
- W2313831712 hasRelatedWork W2950388331 @default.
- W2313831712 hasRelatedWork W3009954623 @default.
- W2313831712 hasRelatedWork W3025532131 @default.
- W2313831712 hasRelatedWork W3098448628 @default.
- W2313831712 hasRelatedWork W3135821596 @default.
- W2313831712 hasRelatedWork W3175244724 @default.
- W2313831712 hasRelatedWork W3186480005 @default.
- W2313831712 hasRelatedWork W4226000657 @default.
- W2313831712 hasRelatedWork W349445598 @default.
- W2313831712 isParatext "false" @default.
- W2313831712 isRetracted "false" @default.
- W2313831712 magId "2313831712" @default.
- W2313831712 workType "article" @default.