Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313834443> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2313834443 endingPage "2618" @default.
- W2313834443 startingPage "2609" @default.
- W2313834443 abstract "The Tpl-2 kinase activates the nuclear factor of activated T cells (NFAT) and induces IL-2 expression in T-cell lines. Here we show that the activation of the IL-2 promoter by Tpl-2 is inhibited by mutant signaling molecules that inhibit the mitogen-activated protein kinase (MAPK) or the calcineurin/NFAT pathways and is promoted by combinations of signaling molecules that activate these pathways. We, therefore, conclude that signals generated by the convergence of the MAPK and the calcineurin/NFAT pathway are necessary and sufficient for the activation of the IL-2 promoter by Tpl-2. The activation of both the IL-2 promoter and an NFAT-driven minimal promoter were shown to depend on signals transduced by Raf1. However, it was only the IL-2 promoter whose activation by Tpl-2 was fully blocked by the dominant negative mutant MEK1S218/222A and the MEK1/MEK2 inhibitor PD098059. Since the activation of NFAT is MAPK-dependent these findings suggested that the activation of MAPK by Tpl-2 is either independent or only partially dependent on MEK1 and MEK2. In addition, they suggested that the activation of the IL-2 promoter is under the control of not only NFAT but also a second factor whose activation is MEK-dependent. Experiments in COS-1 and EL-4 cells confirmed both hypotheses and revealed that the second factor activated by Tpl-2 is NF-kappaB. While the activation of the IL-2 promoter and an NFAT-driven minimal promoter by Tpl-2 was fully blocked by the dominant negative mutant NFAT delta418, it was only partially blocked by the calcineurin inhibitor cyclosporin A suggesting that the Tpl-2-mediated NFAT activation is under the control of a combination of calcineurin-dependent and independent pathways. Both pathways were fully blocked by Bcl-2 or Bcl-X(L)." @default.
- W2313834443 created "2016-06-24" @default.
- W2313834443 creator A5059536565 @default.
- W2313834443 creator A5061198533 @default.
- W2313834443 creator A5090059379 @default.
- W2313834443 date "1998-10-19" @default.
- W2313834443 modified "2023-10-18" @default.
- W2313834443 title "Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB" @default.
- W2313834443 doi "https://doi.org/10.1038/sj.onc.1202460" @default.
- W2313834443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9840924" @default.
- W2313834443 hasPublicationYear "1998" @default.
- W2313834443 type Work @default.
- W2313834443 sameAs 2313834443 @default.
- W2313834443 citedByCount "76" @default.
- W2313834443 countsByYear W23138344432012 @default.
- W2313834443 countsByYear W23138344432013 @default.
- W2313834443 countsByYear W23138344432014 @default.
- W2313834443 countsByYear W23138344432015 @default.
- W2313834443 countsByYear W23138344432016 @default.
- W2313834443 countsByYear W23138344432017 @default.
- W2313834443 countsByYear W23138344432018 @default.
- W2313834443 countsByYear W23138344432020 @default.
- W2313834443 countsByYear W23138344432022 @default.
- W2313834443 countsByYear W23138344432023 @default.
- W2313834443 crossrefType "journal-article" @default.
- W2313834443 hasAuthorship W2313834443A5059536565 @default.
- W2313834443 hasAuthorship W2313834443A5061198533 @default.
- W2313834443 hasAuthorship W2313834443A5090059379 @default.
- W2313834443 hasBestOaLocation W23138344431 @default.
- W2313834443 hasConcept C104317684 @default.
- W2313834443 hasConcept C126322002 @default.
- W2313834443 hasConcept C128057223 @default.
- W2313834443 hasConcept C153911025 @default.
- W2313834443 hasConcept C184235292 @default.
- W2313834443 hasConcept C189938988 @default.
- W2313834443 hasConcept C2911091166 @default.
- W2313834443 hasConcept C55493867 @default.
- W2313834443 hasConcept C57074206 @default.
- W2313834443 hasConcept C62478195 @default.
- W2313834443 hasConcept C71924100 @default.
- W2313834443 hasConcept C86339819 @default.
- W2313834443 hasConcept C86803240 @default.
- W2313834443 hasConcept C95444343 @default.
- W2313834443 hasConceptScore W2313834443C104317684 @default.
- W2313834443 hasConceptScore W2313834443C126322002 @default.
- W2313834443 hasConceptScore W2313834443C128057223 @default.
- W2313834443 hasConceptScore W2313834443C153911025 @default.
- W2313834443 hasConceptScore W2313834443C184235292 @default.
- W2313834443 hasConceptScore W2313834443C189938988 @default.
- W2313834443 hasConceptScore W2313834443C2911091166 @default.
- W2313834443 hasConceptScore W2313834443C55493867 @default.
- W2313834443 hasConceptScore W2313834443C57074206 @default.
- W2313834443 hasConceptScore W2313834443C62478195 @default.
- W2313834443 hasConceptScore W2313834443C71924100 @default.
- W2313834443 hasConceptScore W2313834443C86339819 @default.
- W2313834443 hasConceptScore W2313834443C86803240 @default.
- W2313834443 hasConceptScore W2313834443C95444343 @default.
- W2313834443 hasIssue "20" @default.
- W2313834443 hasLocation W23138344431 @default.
- W2313834443 hasLocation W23138344432 @default.
- W2313834443 hasOpenAccess W2313834443 @default.
- W2313834443 hasPrimaryLocation W23138344431 @default.
- W2313834443 hasRelatedWork W1986191342 @default.
- W2313834443 hasRelatedWork W2035055285 @default.
- W2313834443 hasRelatedWork W2073595175 @default.
- W2313834443 hasRelatedWork W2087708847 @default.
- W2313834443 hasRelatedWork W2102080208 @default.
- W2313834443 hasRelatedWork W2182413836 @default.
- W2313834443 hasRelatedWork W21927977 @default.
- W2313834443 hasRelatedWork W2326663831 @default.
- W2313834443 hasRelatedWork W2397014075 @default.
- W2313834443 hasRelatedWork W2621241233 @default.
- W2313834443 hasVolume "17" @default.
- W2313834443 isParatext "false" @default.
- W2313834443 isRetracted "false" @default.
- W2313834443 magId "2313834443" @default.
- W2313834443 workType "article" @default.