Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313838053> ?p ?o ?g. }
- W2313838053 endingPage "3225" @default.
- W2313838053 startingPage "3218" @default.
- W2313838053 abstract "The onset of diabetic retinopathy is characterized by morphologic alterations of the microvessels, with thickening of the basement membrane, loss of inter-endothelial tight junctions and early and selective loss of pericytes, together with increased vascular permeability, capillary occlusions, microaneurysms and, later, loss of endothelial cells (EC). A key role in the evolution of the disease is played by pericytes, specialized contractile mesenchymal cells of mesodermal origin, that, in capillaries, exert a function similar to smooth muscle cells in larger vessels, regulating vascular tone and perfusion pressure. Thickening of the basement membrane, together with systemic and local hypertension, hyperglycaemia, advanced glycation end-product formation and hypoxia, may disrupt the tight link between pericytes and EC causing pericyte apoptosis, while endothelium, deprived of proliferation control, can give rise to new vessels. Pericyte dropout has great consequences on capillary remodelling and may cause the first abnormalities of the diabetic eye which can be observed clinically. Hyperglycaemia and local hypertension are known to be a direct cause of pericyte apoptosis and dropout, and intracellular biochemical pathways of the glucose metabolites have been explored. However, the exact mechanisms are not yet fully understood and need further clarification in order to develop new effective drugs for the prevention of retinopathy. Keywords: Apoptosis, diabetic retinopathy, endothelial cells, extracellular matrix, pericytes, pericyte loss." @default.
- W2313838053 created "2016-06-24" @default.
- W2313838053 creator A5030120650 @default.
- W2313838053 creator A5084570215 @default.
- W2313838053 date "2013-07-01" @default.
- W2313838053 modified "2023-10-18" @default.
- W2313838053 title "Pericyte Loss in Diabetic Retinopathy: Mechanisms and Consequences" @default.
- W2313838053 cites W1487693355 @default.
- W2313838053 cites W1493971026 @default.
- W2313838053 cites W1529592271 @default.
- W2313838053 cites W1540494156 @default.
- W2313838053 cites W1578613579 @default.
- W2313838053 cites W1804813305 @default.
- W2313838053 cites W1966083787 @default.
- W2313838053 cites W1967172766 @default.
- W2313838053 cites W1971255749 @default.
- W2313838053 cites W1973116613 @default.
- W2313838053 cites W1973418567 @default.
- W2313838053 cites W1973444933 @default.
- W2313838053 cites W1974171881 @default.
- W2313838053 cites W1976442335 @default.
- W2313838053 cites W1978444547 @default.
- W2313838053 cites W1983076538 @default.
- W2313838053 cites W1984984255 @default.
- W2313838053 cites W1987047834 @default.
- W2313838053 cites W1987226166 @default.
- W2313838053 cites W1989287785 @default.
- W2313838053 cites W1990773395 @default.
- W2313838053 cites W1991993617 @default.
- W2313838053 cites W1992737191 @default.
- W2313838053 cites W1993175314 @default.
- W2313838053 cites W1993721436 @default.
- W2313838053 cites W1994471498 @default.
- W2313838053 cites W1996478420 @default.
- W2313838053 cites W1996663238 @default.
- W2313838053 cites W1999247993 @default.
- W2313838053 cites W2004691783 @default.
- W2313838053 cites W2006241828 @default.
- W2313838053 cites W2007880055 @default.
- W2313838053 cites W2009179022 @default.
- W2313838053 cites W2009206983 @default.
- W2313838053 cites W2015035557 @default.
- W2313838053 cites W2016121744 @default.
- W2313838053 cites W2020554150 @default.
- W2313838053 cites W2021427204 @default.
- W2313838053 cites W2024498525 @default.
- W2313838053 cites W2025713457 @default.
- W2313838053 cites W2026562359 @default.
- W2313838053 cites W2028439883 @default.
- W2313838053 cites W2029188025 @default.
- W2313838053 cites W2029399003 @default.
- W2313838053 cites W2030620101 @default.
- W2313838053 cites W2031597817 @default.
- W2313838053 cites W2034351955 @default.
- W2313838053 cites W2043014272 @default.
- W2313838053 cites W2044437167 @default.
- W2313838053 cites W2045926020 @default.
- W2313838053 cites W2047810552 @default.
- W2313838053 cites W2048393160 @default.
- W2313838053 cites W2049332198 @default.
- W2313838053 cites W2051771541 @default.
- W2313838053 cites W2057094512 @default.
- W2313838053 cites W2057986301 @default.
- W2313838053 cites W2059881088 @default.
- W2313838053 cites W2061872503 @default.
- W2313838053 cites W2066290187 @default.
- W2313838053 cites W2067514854 @default.
- W2313838053 cites W2069156601 @default.
- W2313838053 cites W2069488850 @default.
- W2313838053 cites W2069929255 @default.
- W2313838053 cites W2070580300 @default.
- W2313838053 cites W2073019506 @default.
- W2313838053 cites W2073080713 @default.
- W2313838053 cites W2073130171 @default.
- W2313838053 cites W2076229019 @default.
- W2313838053 cites W2076491580 @default.
- W2313838053 cites W2077726387 @default.
- W2313838053 cites W2078835518 @default.
- W2313838053 cites W2079875165 @default.
- W2313838053 cites W2079953735 @default.
- W2313838053 cites W2082730029 @default.
- W2313838053 cites W2086914356 @default.
- W2313838053 cites W2086999880 @default.
- W2313838053 cites W2088152537 @default.
- W2313838053 cites W2092661802 @default.
- W2313838053 cites W2097246733 @default.
- W2313838053 cites W2097937496 @default.
- W2313838053 cites W2098036900 @default.
- W2313838053 cites W2101141314 @default.
- W2313838053 cites W2101819982 @default.
- W2313838053 cites W2103624639 @default.
- W2313838053 cites W2104306818 @default.
- W2313838053 cites W2104738423 @default.
- W2313838053 cites W2104869587 @default.
- W2313838053 cites W2106378155 @default.
- W2313838053 cites W2115337518 @default.
- W2313838053 cites W2115390024 @default.
- W2313838053 cites W2116433781 @default.