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- W2313840283 abstract "We investigated the effects of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) on intracellular Ca2+ concentration ([Ca2+]i) and cell length in isolated and field-stimulated rat cardiomyocytes. [Ca2+]i and cell length of field-stimulated cells were determined simultaneously by confocal laser scan microscopy by using the fluorescent Ca2+ dye Fluo-3. PAF (10−12−10−8M) inhibited systolic [Ca2+]i increase in a time- and concentration-dependent manner. Maximal effects were observed after an incubation time of 6-8 min, resulting in a 17% (10−12M), 41% (10−10M), and 52% (10−8M PAF) inhibition of systolic [Ca2+]i increase. A time- and concentration-dependent decrease in simultaneously measured cell shortening also was demonstrated. Cell shortening was inhibited by 10% (10−12M), 32% (10−10M), and 50% (10−8M) after an incubation time of 8 min. The effects of PAF could be antagonized by the PAF-receptor antagonist WEB 2170. These data demonstrate that PAF receptor-dependently induces a negative inotropic effect, which is correlated with a decrease in systolic [Ca2+]i and is most likely not due to a decrease in myofilament sensitivity." @default.
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- W2313840283 date "1998-05-01" @default.
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- W2313840283 title "Effects of Platelet-Activating Factor on Intracellular Ca2+ Concentration and Contractility in Isolated Cardiomyocytes" @default.
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- W2313840283 doi "https://doi.org/10.1097/00005344-199805000-00015" @default.
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