FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313854837> ?p ?o ?g. }

• W2313854837 endingPage "134" @default.
• W2313854837 startingPage "127" @default.
• W2313854837 abstract "Familial adenomatous polyposis is a well-described, autosomal dominant, inherited syndrome characterized by diffuse polyposis of the colon and rectum as well as various upper gastrointestinal and extraintestinal manifestations. A subset of patients present with fewer colorectal polyps, later age of onset of polyps and cancer, and a predilection toward involvement of the proximal colon. This variant of familial adenomatous polyposis is known as attenuated familial adenomatous polyposis. The purpose of this review is to summarize current knowledge regarding this poorly understood entity and propose guidelines for diagnosis, surveillance, and surgical management.The MEDLINE database was searched from 1985 onward using the keywords, attenuated familial adenomatous polyposis, AFAP, adenomatous polyposis coli gene, and APC gene. Additional articles were identified through the reference sections of retrieved papers. All papers that pertained to attenuated familial adenomatous polyposis or mutations in the APC gene producing an attenuated phenotype were included.Attenuated familial adenomatous polyposis is transmitted in an autosomal dominant fashion. Several distinct mutations within the APC gene have been associated with an attenuated phenotype, but variability of disease expression within kindreds possessing identical mutations makes classification difficult. Polyps are diagnosed at a mean age of 44 years, with cancer diagnosed at a mean of 56 years of age. Frequent involvement of the proximal colon necessitates the use of colonoscopy for surveillance, and infrequent involvement of the rectum supports the role of a total abdominal colectomy and ileorectal anastomosis.Although currently recognized as a distinct clinical entity, attenuated familial adenomatous polyposis may be part of a spectrum of disease that includes familial adenomatous polyposis and is caused by different mutations within the APC gene. Because of its unique characteristics, yet apparent overlap with familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer, increased awareness of attenuated familial adenomatous polyposis should improve diagnosis, surveillance, and treatment strategies in this unique subset of familial polyposis syndromes." @default.
• W2313854837 created "2016-06-24" @default.
• W2313854837 creator A5005957335 @default.
• W2313854837 creator A5006602753 @default.
• W2313854837 creator A5025191979 @default.
• W2313854837 creator A5058432973 @default.
• W2313854837 date "2002-01-01" @default.
• W2313854837 modified "2023-09-26" @default.
• W2313854837 title "Attenuated Familial Adenomatous Polyposis" @default.
• W2313854837 cites W1211385613 @default.
• W2313854837 cites W1499807572 @default.
• W2313854837 cites W1535534560 @default.
• W2313854837 cites W1551075157 @default.
• W2313854837 cites W1556931007 @default.
• W2313854837 cites W181843915 @default.
• W2313854837 cites W1963494178 @default.
• W2313854837 cites W1971884902 @default.
• W2313854837 cites W1979618971 @default.
• W2313854837 cites W1990249393 @default.
• W2313854837 cites W1994684236 @default.
• W2313854837 cites W1997560117 @default.
• W2313854837 cites W1998061293 @default.
• W2313854837 cites W1999596748 @default.
• W2313854837 cites W2004594998 @default.
• W2313854837 cites W2006874765 @default.
• W2313854837 cites W2012164622 @default.
• W2313854837 cites W2012239746 @default.
• W2313854837 cites W2015461236 @default.
• W2313854837 cites W2017125193 @default.
• W2313854837 cites W2017758268 @default.
• W2313854837 cites W2029537790 @default.
• W2313854837 cites W2029669599 @default.
• W2313854837 cites W2031453950 @default.
• W2313854837 cites W2036325678 @default.
• W2313854837 cites W2051315682 @default.
• W2313854837 cites W2057805589 @default.
• W2313854837 cites W2058043554 @default.
• W2313854837 cites W2059813946 @default.
• W2313854837 cites W2067548151 @default.
• W2313854837 cites W2070773022 @default.
• W2313854837 cites W2071595471 @default.
• W2313854837 cites W2072362704 @default.
• W2313854837 cites W2076430893 @default.
• W2313854837 cites W2079014026 @default.
• W2313854837 cites W2079252064 @default.
• W2313854837 cites W2081758458 @default.
• W2313854837 cites W2082764211 @default.
• W2313854837 cites W2088152407 @default.
• W2313854837 cites W2095048776 @default.
• W2313854837 cites W2099727102 @default.
• W2313854837 cites W2100880689 @default.
• W2313854837 cites W2103923927 @default.
• W2313854837 cites W2123240632 @default.
• W2313854837 cites W2148018436 @default.
• W2313854837 cites W2157944279 @default.
• W2313854837 cites W2332836514 @default.
• W2313854837 cites W2336169581 @default.
• W2313854837 cites W2336215030 @default.
• W2313854837 cites W2412725277 @default.
• W2313854837 cites W2413777350 @default.
• W2313854837 cites W2423454373 @default.
• W2313854837 cites W2017312736 @default.
• W2313854837 doi "https://doi.org/10.1007/s10350-004-6127-y" @default.
• W2313854837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11786778" @default.
• W2313854837 hasPublicationYear "2002" @default.
• W2313854837 type Work @default.
• W2313854837 sameAs 2313854837 @default.
• W2313854837 citedByCount "152" @default.
• W2313854837 countsByYear W23138548372012 @default.
• W2313854837 countsByYear W23138548372013 @default.
• W2313854837 countsByYear W23138548372014 @default.
• W2313854837 countsByYear W23138548372015 @default.
• W2313854837 countsByYear W23138548372016 @default.
• W2313854837 countsByYear W23138548372017 @default.
• W2313854837 countsByYear W23138548372018 @default.
• W2313854837 countsByYear W23138548372019 @default.
• W2313854837 countsByYear W23138548372020 @default.
• W2313854837 countsByYear W23138548372021 @default.
• W2313854837 countsByYear W23138548372022 @default.
• W2313854837 countsByYear W23138548372023 @default.
• W2313854837 crossrefType "journal-article" @default.
• W2313854837 hasAuthorship W2313854837A5005957335 @default.
• W2313854837 hasAuthorship W2313854837A5006602753 @default.
• W2313854837 hasAuthorship W2313854837A5025191979 @default.
• W2313854837 hasAuthorship W2313854837A5058432973 @default.
• W2313854837 hasConcept C104317684 @default.
• W2313854837 hasConcept C121608353 @default.
• W2313854837 hasConcept C126322002 @default.
• W2313854837 hasConcept C142724271 @default.
• W2313854837 hasConcept C2776667177 @default.
• W2313854837 hasConcept C2778237340 @default.
• W2313854837 hasConcept C2778435480 @default.
• W2313854837 hasConcept C2780814781 @default.
• W2313854837 hasConcept C2781074409 @default.
• W2313854837 hasConcept C2994225774 @default.
• W2313854837 hasConcept C501734568 @default.
• W2313854837 hasConcept C526805850 @default.
• W2313854837 hasConcept C54355233 @default.

• next