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- W2313859029 abstract "Aims: Oxcarbazepine was formulated as suspension in order to perk up the palatability, augment bioavailability of the product, furthermore extended to estimate good degree of in vitro in vivo correlation (IVIVC). Study Design: Formulation and Evaluation of Oxcarbazepine Suspension: In Vitro/In Vivo Correlation Place and Duration of Study: Birla Institute of Technological Sciences- Hyderabad, India between July 2011 to January 2012 Methodology: Oxcarbazepine had poor aqueous solubility, thus the solubility was increased by hydrotropes then formulated into suspension using taragum as viscosity enhancer. Further validity of dissolution study was extended by In vitro/In vivo correlation using level A method. Results: These suspensions were observed for in vitro dissolution profile and studied for in vivo pharmacokinetic profile, from the obtained values, a level A IVIVC modeling was observed, interestingly from the results attained suspension showed almost 98% drug release (FDR) and 85% drug absorbed (FDA) in 90min. Fascinatingly, from the correlation between FDR and FDA, slope and regression co-efficient obtained was near to 1.0 indicated good linearity. Conclusion: In conclusion, a point-to-point link from the level A which was a keystone of acceptable and reliable correlation was achieved." @default.
- W2313859029 created "2016-06-24" @default.
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- W2313859029 date "2014-01-10" @default.
- W2313859029 modified "2023-10-18" @default.
- W2313859029 title "Formulation and Evaluation of Oxcarbazepine Suspension: In vitro/In vivo Correlation" @default.
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- W2313859029 doi "https://doi.org/10.9734/bjpr/2014/4763" @default.
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