Matches in SemOpenAlex for { <https://semopenalex.org/work/W2313883293> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2313883293 endingPage "S165" @default.
- W2313883293 startingPage "S164" @default.
- W2313883293 abstract "Numerous compounds isolated from Ginseng have been shown to exhibit various biological activities, including antioxidant, anti-carcinogenic, anti-mutagenic, and anti-tumor activities. Recent research has focused on the potential values of these compounds in the prevention and treatment of human cancers. The anti-tumor activity of 25-hydroxyprotopanaxadiol (25-OH-PPD), a natural compound isolated from Panax ginseng, has been established in previous study. In the current study, we investigated the anti-tumor activity of three derivatives of 25-OH-PPD, namely xl, 1c, and 8b with respect to lung cancer. All three compounds significantly inhibited the growth of the human lung cancer cells A549 and H460. Oral administration of these compounds significantly inhibited the growth of xenograft tumors in mice without affecting body weight. Further mechanistic study demonstrated that these compounds could decrease the expression levels of β-catenin and its downstream targets Cyclin D1, CDK4, and c-myc in lung cancer cells. Taken together, the results suggested that the anti-growth activity exerted by these 25-OH-PPD derivatives against lung cancer cells probably involved β-catenin-mediated signaling pathway, a finding that could have important implication for chemotherapeutic strategy aiming at the treatment of lung cancer." @default.
- W2313883293 created "2016-06-24" @default.
- W2313883293 creator A5002633126 @default.
- W2313883293 creator A5043350018 @default.
- W2313883293 creator A5044491898 @default.
- W2313883293 creator A5048777304 @default.
- W2313883293 creator A5058626937 @default.
- W2313883293 creator A5064996803 @default.
- W2313883293 creator A5067525228 @default.
- W2313883293 creator A5072561497 @default.
- W2313883293 creator A5086809005 @default.
- W2313883293 date "2012-06-01" @default.
- W2313883293 modified "2023-09-29" @default.
- W2313883293 title "Histopathological findings, oxidative stress and ultrasound measurements in heart tissues after long term rabbits exposure to chlorpyrifos" @default.
- W2313883293 doi "https://doi.org/10.1016/j.toxlet.2012.03.597" @default.
- W2313883293 hasPublicationYear "2012" @default.
- W2313883293 type Work @default.
- W2313883293 sameAs 2313883293 @default.
- W2313883293 citedByCount "0" @default.
- W2313883293 crossrefType "journal-article" @default.
- W2313883293 hasAuthorship W2313883293A5002633126 @default.
- W2313883293 hasAuthorship W2313883293A5043350018 @default.
- W2313883293 hasAuthorship W2313883293A5044491898 @default.
- W2313883293 hasAuthorship W2313883293A5048777304 @default.
- W2313883293 hasAuthorship W2313883293A5058626937 @default.
- W2313883293 hasAuthorship W2313883293A5064996803 @default.
- W2313883293 hasAuthorship W2313883293A5067525228 @default.
- W2313883293 hasAuthorship W2313883293A5072561497 @default.
- W2313883293 hasAuthorship W2313883293A5086809005 @default.
- W2313883293 hasConcept C114246631 @default.
- W2313883293 hasConcept C121608353 @default.
- W2313883293 hasConcept C126322002 @default.
- W2313883293 hasConcept C142724271 @default.
- W2313883293 hasConcept C185592680 @default.
- W2313883293 hasConcept C199835354 @default.
- W2313883293 hasConcept C204787440 @default.
- W2313883293 hasConcept C2776151105 @default.
- W2313883293 hasConcept C2776256026 @default.
- W2313883293 hasConcept C2777714996 @default.
- W2313883293 hasConcept C2779232237 @default.
- W2313883293 hasConcept C29537977 @default.
- W2313883293 hasConcept C502942594 @default.
- W2313883293 hasConcept C55493867 @default.
- W2313883293 hasConcept C71924100 @default.
- W2313883293 hasConcept C98274493 @default.
- W2313883293 hasConceptScore W2313883293C114246631 @default.
- W2313883293 hasConceptScore W2313883293C121608353 @default.
- W2313883293 hasConceptScore W2313883293C126322002 @default.
- W2313883293 hasConceptScore W2313883293C142724271 @default.
- W2313883293 hasConceptScore W2313883293C185592680 @default.
- W2313883293 hasConceptScore W2313883293C199835354 @default.
- W2313883293 hasConceptScore W2313883293C204787440 @default.
- W2313883293 hasConceptScore W2313883293C2776151105 @default.
- W2313883293 hasConceptScore W2313883293C2776256026 @default.
- W2313883293 hasConceptScore W2313883293C2777714996 @default.
- W2313883293 hasConceptScore W2313883293C2779232237 @default.
- W2313883293 hasConceptScore W2313883293C29537977 @default.
- W2313883293 hasConceptScore W2313883293C502942594 @default.
- W2313883293 hasConceptScore W2313883293C55493867 @default.
- W2313883293 hasConceptScore W2313883293C71924100 @default.
- W2313883293 hasConceptScore W2313883293C98274493 @default.
- W2313883293 hasLocation W23138832931 @default.
- W2313883293 hasOpenAccess W2313883293 @default.
- W2313883293 hasPrimaryLocation W23138832931 @default.
- W2313883293 hasRelatedWork W1967103478 @default.
- W2313883293 hasRelatedWork W1982729421 @default.
- W2313883293 hasRelatedWork W2032912323 @default.
- W2313883293 hasRelatedWork W2271907559 @default.
- W2313883293 hasRelatedWork W2333542836 @default.
- W2313883293 hasRelatedWork W2372561159 @default.
- W2313883293 hasRelatedWork W2390152934 @default.
- W2313883293 hasRelatedWork W2748952813 @default.
- W2313883293 hasRelatedWork W2899084033 @default.
- W2313883293 hasRelatedWork W3186342291 @default.
- W2313883293 hasVolume "211" @default.
- W2313883293 isParatext "false" @default.
- W2313883293 isRetracted "false" @default.
- W2313883293 magId "2313883293" @default.
- W2313883293 workType "article" @default.