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- W2313888048 abstract "The application of gene therapy technology in the setting of solid organ transplantation has been greatly enhanced by the recent development of new gene delivery vehicles that are safer and more efficient. The transplant setting provides a unique advantage in that a graft can be efficiently transduced before transplantation by donor pretreatment or gene delivery during cold preservation. The expression of the transferred sequences within the graft may then allow control of local events, such as inhibition of the alloimmune response, prevention of cell death, or assistance in cellular recovery. It is the selection and design of the shuttle vector that determines the length and timing of expression of the protein. This review summarizes recent and novel advances in the application of gene therapy in organ and cellular transplantation." @default.
- W2313888048 created "2016-06-24" @default.
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- W2313888048 date "2001-12-01" @default.
- W2313888048 modified "2023-09-25" @default.
- W2313888048 title "Gene therapy and graft modification" @default.
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- W2313888048 doi "https://doi.org/10.1097/00075200-200112000-00013" @default.
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