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• W2313973611 abstract "Event Abstract Back to Event Preparation of biodegradable and biocompatible emulsion templated scaffolds for tissue engineering by thiol-acrylate polymerization of polycaprolactone macromers Caitlin Langford1, David W. Johnson2 and Neil R. Cameron1 1 Monash University, Materials Science and Engineering, Australia 2 Durham University, Department of Chemistry, United Kingdom Introduction: Highly porous polymers with well-defined morphologies can be prepared by the emulsion templating process[1]. The process, whereby the continuous phase of a high internal phase emulsion (HIPE) is polymerized, results in materials referred to as polyHIPEs. Recent developments in the photo-initiated polymerization of HIPEs have allowed for the preparation of polyHIPE polymers from monomers which form highly unstable emulsions, such as multifunctional thiol and alkene (typically acrylate) monomers[2]. PolyHIPEs prepared from a trifunctional thiol and polycaprolactone-triacrylate (PCL-TA) have been shown to be biodegradable, and biocompatible in initial cell culture studies[3]. Experimental Methods: Biodegradable polyHIPEs were prepared by radically initiated network formation between combinations of a trifuntional thiol, and PCL-TA (Figure 1). Example procedure: The HIPE oil phase, consisting of a trithiol (0.6 g), PCL-TA (2.0 g), solvent (4 ml), surfactant (3 wt% of organic phase), and photoinitiator (7 wt% of monomer content) were combined in a 2-neck round bottom flask with continuous stirring at 350 rpm from an overhead stirrer fitted with a D shaped PTFE paddle. Water (90 wt% of total emulsion) was added dropwise to form the HIPE. The HIPE was then poured into a mould and cured by passing under a UV lamp. The resulting polyHIPE is then washed by immersion in acetone and dried under reduced pressure. Figure 1. Crosslinkers used in the preparation of PCL-TA polyHIPEs. Results and Discussion: A range of biodegradable polyHIPE polymers can be prepared by the described method by varying the thiol and acrylate monomers used. An example of the polymer morphology obtained is shown in Figure 2. Figure 2. SEM image of thiol-PCL polyHIPE. Scale bar = 500 µm. The open, interconnected morphology observed in Figure 2 allows for cell penetration into the porous polymer, although cell growth is mainly observed at the surface (Figure 3). The successful culture of a fibroblast cell line (L929) on PCL-TA polyHIPEs for periods of up to 7 days (Figure 3) indicates that the polyHIPEs are biocompatible. Figure 3. a) MTT assay of cultured cell line on PCL-TA polyHIPE vs control. b, c) Micrographs of H&E stained sections of PCL-TA polyHIPE after 3 (b) and 7 (c) days of culture. Scale bar = 100 µm. Conclusion: Porous polymers (polyHIPEs) have been prepared from trifuntional thiol and PCL-TA monomers by emulsion templating. These polymers have been shown to be biodegradable and biocompatible in initial cell culture studies. Monash University; Support from the “Precision Polymer Materials (P2M)” RNP programme from the European Science Foundation is acknowledged. The European Commission (FP7-SME-2008-2-243542-HIP)References:[1] Cameron N. R., Polymer, 46:1439-1449, 2005[2] Lovelady E., et al., Polym. Chem., 2:559-562, 2011[3] Johnson D. W., et al., Polym. Chem., DOI: 10.1039/C5PY00721F Keywords: Biocompatibility, 3D scaffold, Biodegradable material, Polymeric material Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Synthetic scaffolds as extracellular matrices Citation: Langford C, Johnson DW and Cameron NR (2016). Preparation of biodegradable and biocompatible emulsion templated scaffolds for tissue engineering by thiol-acrylate polymerization of polycaprolactone macromers. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02956 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Caitlin Langford David W Johnson Neil R Cameron Google Caitlin Langford David W Johnson Neil R Cameron Google Scholar Caitlin Langford David W Johnson Neil R Cameron PubMed Caitlin Langford David W Johnson Neil R Cameron Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2313973611 title "Preparation of biodegradable and biocompatible emulsion templated scaffolds for tissue engineering by thiol-acrylate polymerization of polycaprolactone macromers" @default.
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