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- W2314047741 abstract "Structural and functional neuroimaging studies are providing important insights into the causes and treatment of schizophrenia.Research using magnetic resonance imaging has now demonstrated that the deficits in cerebral gray matter volume found in schizophrenia appear to be independent of the age of onset and are detectable at the time of the first episode of psychosis. The magnitudes of these deficits appear to be smaller at the time of the first episode, raising the possibility that there may be some progression early in the course of illness. Although most studies have not found an association between duration of illness and the magnitude of the brain abnormalities, recent longitudinal studies suggest that some progression of brain abnormalities may take place in the early years of the illness. Functional brain imaging studies using positron emission tomography and single-photon emission computed tomography have focused on characterizing brain areas involved in hallucinations and on demonstrating differences in presynaptic dopamine release in schizophrenia. Evidence continues to accumulate supporting the existence of a narrow window of D2 receptor occupancy for optimal dosing of antipsychotic medication. Positron emission tomography and single-photon emission computed tomography will prove to be invaluable tools in the search for new strategies for the treatment of schizophrenia." @default.
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- W2314047741 date "1998-01-01" @default.
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- W2314047741 title "New insights into schizophrenia from neuroimaging" @default.
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