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• W2314055805 startingPage "963" @default.
• W2314055805 abstract "We systematically investigated the effects of loop length on the conformation, thermodynamic stability, and hydration of DNA G-quadruplexes under dilute and molecular crowding conditions in the presence of Na(+). Structural analysis showed that molecular crowding induced conformational switches of oligonucleotides with the longer guanine stretch and the shorter thymine loop. Thermodynamic parameters further demonstrated that the thermodynamic stability of G-quadruplexes increased by increasing the loop length from two to four, whereas it decreased by increasing the loop length from four to six. Interestingly, we found by osmotic pressure analysis that the number of water molecules released from the G-quadruplex decreased with increasing thermodynamic stability. We assumed that base-stacking interactions within the loops not only stabilized the whole G-quadruplex structure but also created hydration sites by accumulating nucleotide functional groups. The molecular crowding effects on the stability of G-quadruplexes composed of abasic sites, which reduce the stacking interactions at the loops, further demonstrated that G-quadruplexes with fewer stacking interactions within the loops released a larger number of water molecules upon folding. These results showed that the stacking interactions within the loops determined the thermodynamic stability and hydration of the whole G-quadruplex." @default.
• W2314055805 created "2016-06-24" @default.
• W2314055805 creator A5001916929 @default.
• W2314055805 creator A5041513545 @default.
• W2314055805 creator A5058387972 @default.
• W2314055805 creator A5072267207 @default.
• W2314055805 date "2012-11-27" @default.
• W2314055805 modified "2023-10-16" @default.
• W2314055805 title "Thermodynamics-Hydration Relationships within Loops That Affect G-Quadruplexes under Molecular Crowding Conditions" @default.
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• W2314055805 doi "https://doi.org/10.1021/jp308402v" @default.
• W2314055805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23153339" @default.
• W2314055805 hasPublicationYear "2012" @default.
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