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- W2314085000 abstract "Purpose: In osteoarthritis (OA), subchondral bone changes have been related to pain perception, as well to alter the joint’s mechanical environment influencing progression of cartilage degeneration. Less well known are the exact biochemical interactions between subchondral bone and cartilage and by which biochemical changes bone may influence cartilage degradation. The present study evaluates if biochemical interactions between bone and cartilage contribute to progression and/or repair processes in OA. Methods: Human knee subchondral osteoblasts were isolated from healthy donors (n = 14) and OA patients (n = 16). Osteoblast culture supernatants were subsequently tested on both healthy and osteoarthritic cartilage and changes in proteoglycan (PG) synthesis were studied. Additionally, osteoblast culture supernatants were assessed for 66 different mediators potentially involved in cartilage modulation by Luminex analysis. Results: Supernatant of subchondral osteoblasts cultures of healthy joints had no effect on the PG-synthesis of healthy cartilage. However, when supernatants derived of OA joints were added to healthy cartilage cultures, a significant decrease in PG-synthesis was observed (-30%; p<0.001 vs. control). In contrast, supernatants of OA derived osteoblasts had no effect on OA cartilage. Moreover, supernatant derived from healthy subchondral osteoblast cultures stimulated repair of OA cartilage; an increased PG synthesis (+34%; p = 0.035) was observed. Eleven mediators were identified with a difference between healthy and OA derived osteoblast cultures (table 1). TSLP, MCP-1, Leptin, IL-8, IL-21, IL-1a, GM-CSF, and Cathepsin-S had higher levels in the OA-osteoblasts, while PAI-1, IL-6, and Resistin had lower levels compared to healthy osteoblasts. Conclusions: These data show that biochemical interactions between bone and cartilage potentially contribute to repair and degradation processes in OA. Importantly, these data are supportive to target osteoarthritic bone in OA to modulate cartilage repair.Table 1Different mediators produced by healthy and OA osteoblasts measured by LUMINEXOsteoblastsTSLP pg/mlPAI-1 ng/mlMCP-1 ng/mlLeptin pg/mlResitin ng/mlIL-6 ng/mlIL-8 ng/mlIL-21 ng/mlIl-1a pg/mlGM-CSF pg/mlCathepsin S pg/mlHealthy13±9184±1307±9366±15120±326±66±521±224±519±14447±235OA19±1391±3220±12452±1455±33±318±923±129±643±261114±630p0.0880.0160.0030.0290.0840.055<0.0010.0340.028<0.0010.002 Open table in a new tab" @default.
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- W2314085000 date "2014-04-01" @default.
- W2314085000 modified "2023-10-03" @default.
- W2314085000 title "The biochemical interaction between subchondral bone and cartilage in osteoarthritis" @default.
- W2314085000 doi "https://doi.org/10.1016/j.joca.2014.02.652" @default.
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