Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314124706> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2314124706 endingPage "S106" @default.
- W2314124706 startingPage "S106" @default.
- W2314124706 abstract "We recently created and reported a novel murine model of frostbite injury that mimics human skin pathophysiology, with the intent of allowing screening-type testing of therapeutic interventions directed against frostbite. Using this model, the current investigation tested a poly-arginine compound for the treatment of frostbite injury. A unique topical compound containing poly-arginine was tested. There were seven subject conditions: pre-treatment with placebo, pre-treatment with compound, post-treatment with placebo, post-treatment with compound, pre- and post-treatment with placebo, pre- and post-treatment with compound, and untreated (control). Mice were monitored for 28 days for healing rate and tissue loss until the wounds were fully healed. Certain mice were sacrificed at scheduled intervals during this 28-day period for histological analysis. Wounds were measured to calculate wound size and tissue loss. There was a decrease (<40% in both pre-treatment and pre-/post-treatment conditions versus >43% in all other conditions) in tissue loss in the mice treated with poly-arginine. All conditions completely healed (100% epithelialization) by day 27, with the placebo conditions showing complete healing sooner (day 20 vs. day 25) than subjects treated with poly-arginine. Histological analysis was performed for neovascularization, re-epithelialization, inflammation, and tissue necrosis. In a murine model for frostbite injury, this unique poly-arginine compound shows a potentially beneficial effect. This warrants testing on a larger animal model more closely resembling frostbite injury leading to limb loss." @default.
- W2314124706 created "2016-06-24" @default.
- W2314124706 creator A5043000574 @default.
- W2314124706 creator A5054575772 @default.
- W2314124706 creator A5069276604 @default.
- W2314124706 creator A5078996267 @default.
- W2314124706 date "2013-10-01" @default.
- W2314124706 modified "2023-09-27" @default.
- W2314124706 title "Poly-Arginine Compound Tested in a Murine Model for Frostbite" @default.
- W2314124706 doi "https://doi.org/10.1016/j.annemergmed.2013.07.118" @default.
- W2314124706 hasPublicationYear "2013" @default.
- W2314124706 type Work @default.
- W2314124706 sameAs 2314124706 @default.
- W2314124706 citedByCount "0" @default.
- W2314124706 crossrefType "journal-article" @default.
- W2314124706 hasAuthorship W2314124706A5043000574 @default.
- W2314124706 hasAuthorship W2314124706A5054575772 @default.
- W2314124706 hasAuthorship W2314124706A5069276604 @default.
- W2314124706 hasAuthorship W2314124706A5078996267 @default.
- W2314124706 hasBestOaLocation W23141247061 @default.
- W2314124706 hasConcept C141071460 @default.
- W2314124706 hasConcept C142724271 @default.
- W2314124706 hasConcept C185592680 @default.
- W2314124706 hasConcept C204787440 @default.
- W2314124706 hasConcept C27081682 @default.
- W2314124706 hasConcept C2777468819 @default.
- W2314124706 hasConcept C2780269544 @default.
- W2314124706 hasConcept C2781166493 @default.
- W2314124706 hasConcept C515207424 @default.
- W2314124706 hasConcept C55493867 @default.
- W2314124706 hasConcept C71924100 @default.
- W2314124706 hasConceptScore W2314124706C141071460 @default.
- W2314124706 hasConceptScore W2314124706C142724271 @default.
- W2314124706 hasConceptScore W2314124706C185592680 @default.
- W2314124706 hasConceptScore W2314124706C204787440 @default.
- W2314124706 hasConceptScore W2314124706C27081682 @default.
- W2314124706 hasConceptScore W2314124706C2777468819 @default.
- W2314124706 hasConceptScore W2314124706C2780269544 @default.
- W2314124706 hasConceptScore W2314124706C2781166493 @default.
- W2314124706 hasConceptScore W2314124706C515207424 @default.
- W2314124706 hasConceptScore W2314124706C55493867 @default.
- W2314124706 hasConceptScore W2314124706C71924100 @default.
- W2314124706 hasIssue "4" @default.
- W2314124706 hasLocation W23141247061 @default.
- W2314124706 hasOpenAccess W2314124706 @default.
- W2314124706 hasPrimaryLocation W23141247061 @default.
- W2314124706 hasRelatedWork W2002120878 @default.
- W2314124706 hasRelatedWork W2003938723 @default.
- W2314124706 hasRelatedWork W2047967234 @default.
- W2314124706 hasRelatedWork W2118496982 @default.
- W2314124706 hasRelatedWork W2364998975 @default.
- W2314124706 hasRelatedWork W2369162477 @default.
- W2314124706 hasRelatedWork W2439875401 @default.
- W2314124706 hasRelatedWork W4238867864 @default.
- W2314124706 hasRelatedWork W2519357708 @default.
- W2314124706 hasRelatedWork W2525756941 @default.
- W2314124706 hasVolume "62" @default.
- W2314124706 isParatext "false" @default.
- W2314124706 isRetracted "false" @default.
- W2314124706 magId "2314124706" @default.
- W2314124706 workType "article" @default.