FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314136536> ?p ?o ?g. }

• W2314136536 endingPage "112" @default.
• W2314136536 startingPage "107" @default.
• W2314136536 abstract "Experiments were performed in cat papillary muscles contracting isometrically at a constant frequency (0.2 Hz) and temperature (29°C). Contractility was evaluated by developed tension (T) and its first derivative (T˚). Hypercapnia was induced by switching the perfusate equilibrated with 5% CO2-95% O2 to a solution equilibrated with 12% CO2 – 88% O2. Composition of this second solution was either identical to the first one (pH0 6.90, experiments at variable pH0, vpH) or with a higher [NaHCO3] to keep pH0 constant at 7.4 during the hypercapnic period (experiments at constant pH0, cpH0). The increase in CO2elicited a similar decrease in contractility at cpH0 and vpH0. Minimal mean + T˚ values were 58.5 ± 2.9% nd 55.4 ± 3.2% and occurred at 3.6 ± 0.75 min and 4.5 ± 1.52 min of hypercapnia, at cpH0and vpH0 respectively. Contractility recovery after the initial fall, was significantly greater when hypercapnia occurred at cpH0. Return to normocapnia elicited an increase in contractility over control values (overshoot). When [Na+]e was decreased by 60%, hypercapnia produced a similar negative inotropic effect than at control [Na+]e but significantly diminished the degree of recovery at either cpH0 or vpH0. Hypercapnic acidosis at cpH0, in the presence of 5 × 10−6M ethylisopropylamiloride (Eipa), a specific inhibitor of Na+/H+ exchange, evoked a maximum negative inotropic effect significantly greater than in its absence and suppressed the recovery of contractility. In all cases the magnitude of the overshoot upon return to normocapnia paralleled the magnitude of contractility recovery during hypercapnia. The results suggest that the recovery of contractility during hypercapnic acidosis is entirely depedent upon the Na+/H+exchanger." @default.
• W2314136536 created "2016-06-24" @default.
• W2314136536 creator A5026647249 @default.
• W2314136536 creator A5047989321 @default.
• W2314136536 creator A5071061476 @default.
• W2314136536 date "1993-01-01" @default.
• W2314136536 modified "2023-09-27" @default.
• W2314136536 title "Role of Na+/H+exchange in the recovery of contractility during hypercapnia in cat papillary muscles" @default.
• W2314136536 cites W1490746554 @default.
• W2314136536 cites W1966647373 @default.
• W2314136536 cites W1973123569 @default.
• W2314136536 cites W1985832800 @default.
• W2314136536 cites W1988744570 @default.
• W2314136536 cites W1996140321 @default.
• W2314136536 cites W2017619831 @default.
• W2314136536 cites W2022128427 @default.
• W2314136536 cites W2023318071 @default.
• W2314136536 cites W2028764122 @default.
• W2314136536 cites W2055138529 @default.
• W2314136536 cites W2066350875 @default.
• W2314136536 cites W2067877174 @default.
• W2314136536 cites W2078738419 @default.
• W2314136536 cites W2080850817 @default.
• W2314136536 cites W2086245657 @default.
• W2314136536 cites W2088205844 @default.
• W2314136536 cites W2089611263 @default.
• W2314136536 cites W2089675043 @default.
• W2314136536 cites W2098257216 @default.
• W2314136536 cites W2098349464 @default.
• W2314136536 cites W2098572496 @default.
• W2314136536 cites W2108719727 @default.
• W2314136536 cites W2114402920 @default.
• W2314136536 cites W2114598380 @default.
• W2314136536 cites W2117277623 @default.
• W2314136536 cites W2117631539 @default.
• W2314136536 cites W2118137246 @default.
• W2314136536 cites W2119079490 @default.
• W2314136536 cites W2137664405 @default.
• W2314136536 cites W2154679454 @default.
• W2314136536 cites W2174970607 @default.
• W2314136536 cites W2603595896 @default.
• W2314136536 doi "https://doi.org/10.3109/13813459309008877" @default.
• W2314136536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7689353" @default.
• W2314136536 hasPublicationYear "1993" @default.
• W2314136536 type Work @default.
• W2314136536 sameAs 2314136536 @default.
• W2314136536 citedByCount "3" @default.
• W2314136536 crossrefType "journal-article" @default.
• W2314136536 hasAuthorship W2314136536A5026647249 @default.
• W2314136536 hasAuthorship W2314136536A5047989321 @default.
• W2314136536 hasAuthorship W2314136536A5071061476 @default.
• W2314136536 hasConcept C126322002 @default.
• W2314136536 hasConcept C134018914 @default.
• W2314136536 hasConcept C185592680 @default.
• W2314136536 hasConcept C2777037550 @default.
• W2314136536 hasConcept C2778553927 @default.
• W2314136536 hasConcept C2781382112 @default.
• W2314136536 hasConcept C39133596 @default.
• W2314136536 hasConcept C42219234 @default.
• W2314136536 hasConcept C71924100 @default.
• W2314136536 hasConceptScore W2314136536C126322002 @default.
• W2314136536 hasConceptScore W2314136536C134018914 @default.
• W2314136536 hasConceptScore W2314136536C185592680 @default.
• W2314136536 hasConceptScore W2314136536C2777037550 @default.
• W2314136536 hasConceptScore W2314136536C2778553927 @default.
• W2314136536 hasConceptScore W2314136536C2781382112 @default.
• W2314136536 hasConceptScore W2314136536C39133596 @default.
• W2314136536 hasConceptScore W2314136536C42219234 @default.
• W2314136536 hasConceptScore W2314136536C71924100 @default.
• W2314136536 hasIssue "2" @default.
• W2314136536 hasLocation W23141365361 @default.
• W2314136536 hasLocation W23141365362 @default.
• W2314136536 hasOpenAccess W2314136536 @default.
• W2314136536 hasPrimaryLocation W23141365361 @default.
• W2314136536 hasRelatedWork W2004729422 @default.
• W2314136536 hasRelatedWork W2018458203 @default.
• W2314136536 hasRelatedWork W2028330714 @default.
• W2314136536 hasRelatedWork W2036072514 @default.
• W2314136536 hasRelatedWork W2063483887 @default.
• W2314136536 hasRelatedWork W2175702421 @default.
• W2314136536 hasRelatedWork W2902889460 @default.
• W2314136536 hasRelatedWork W3187046504 @default.
• W2314136536 hasRelatedWork W4235780019 @default.
• W2314136536 hasRelatedWork W1865580031 @default.
• W2314136536 hasVolume "101" @default.
• W2314136536 isParatext "false" @default.
• W2314136536 isRetracted "false" @default.
• W2314136536 magId "2314136536" @default.
• W2314136536 workType "article" @default.