Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314151648> ?p ?o ?g. }
- W2314151648 endingPage "1197" @default.
- W2314151648 startingPage "1189" @default.
- W2314151648 abstract "Background Medication overuse headache (MOH) is a disabling health problem. Convincing evidence attributes a pathophysiologic role to central sensitization. By recording somatosensory evoked potentials (SSEPs) in patients with MOH, we observed increased sensitization and deficient habituation to repetitive sensory stimuli consistent with drug overuse. The renin–angiotensin system in the brain seems to play a relevant role in neural plasticity and dependence behavior. We therefore sought differences in SSEP sensitization and habituation in patients with MOH who underwent angiotensin converting enzyme (ACE) I/D polymorphism analysis. Methods We recorded median-nerve SSEPs (two blocks of 100 sweeps) in 43 patients with MOH. We measured N20–P25 amplitudes, and assessed sensitization using the first block amplitudes, and habituation using amplitude changes between the two sequential blocks. According to their genotype, subjects were divided into three groups: “D/D”, “D/I” and “I/I” carriers. Results The habituation slope of the two SSEP block amplitudes was significantly increased in the D/D subgroup ( n = 16) with respect to that of the I/I subgroup ( n = 6), with the D/I subgroup ( n = 21) falling in between. In D/D carriers, the habituation slope correlated positively with the duration of the overuse headache, and the first SSEP block amplitudes, a measure of sensitization, increased in strict relationship with the type of overused medication in the MOH patients overall and in the D/D subgroup; this was not so in the D/I and I/I subgroups. Conclusion In patients with MOH, the homozygote D/D ACE polymorphism influences habituation and sensitization to repeated sensory stimuli in strict relationship with medication overuse. We suggest that angiotensin peptides influence neuronal mechanisms of plasticity by interacting with central monoaminergic synaptic transmission." @default.
- W2314151648 created "2016-06-24" @default.
- W2314151648 creator A5001876336 @default.
- W2314151648 creator A5007756770 @default.
- W2314151648 creator A5010978409 @default.
- W2314151648 creator A5039705796 @default.
- W2314151648 creator A5052410051 @default.
- W2314151648 creator A5057559893 @default.
- W2314151648 creator A5068237948 @default.
- W2314151648 creator A5080020006 @default.
- W2314151648 creator A5080500923 @default.
- W2314151648 date "2012-10-10" @default.
- W2314151648 modified "2023-09-26" @default.
- W2314151648 title "Cortical response to somatosensory stimulation in medication overuse headache patients is influenced by angiotensin converting enzyme (ACE) I/D genetic polymorphism" @default.
- W2314151648 cites W115551870 @default.
- W2314151648 cites W1712295053 @default.
- W2314151648 cites W1963996437 @default.
- W2314151648 cites W1967323580 @default.
- W2314151648 cites W1973686203 @default.
- W2314151648 cites W1975229213 @default.
- W2314151648 cites W1981983302 @default.
- W2314151648 cites W1982394915 @default.
- W2314151648 cites W1982706492 @default.
- W2314151648 cites W1985932381 @default.
- W2314151648 cites W1995862402 @default.
- W2314151648 cites W1999768227 @default.
- W2314151648 cites W2001727607 @default.
- W2314151648 cites W2007009569 @default.
- W2314151648 cites W2007178349 @default.
- W2314151648 cites W2008329375 @default.
- W2314151648 cites W2023030545 @default.
- W2314151648 cites W2028558949 @default.
- W2314151648 cites W2035014861 @default.
- W2314151648 cites W2035259027 @default.
- W2314151648 cites W2038180494 @default.
- W2314151648 cites W2038381750 @default.
- W2314151648 cites W2052852190 @default.
- W2314151648 cites W2055171682 @default.
- W2314151648 cites W2063432437 @default.
- W2314151648 cites W2065823183 @default.
- W2314151648 cites W2076320862 @default.
- W2314151648 cites W2085174584 @default.
- W2314151648 cites W2096810815 @default.
- W2314151648 cites W2097532633 @default.
- W2314151648 cites W2099215666 @default.
- W2314151648 cites W2100699868 @default.
- W2314151648 cites W2108579638 @default.
- W2314151648 cites W2109774219 @default.
- W2314151648 cites W2117095296 @default.
- W2314151648 cites W2124675313 @default.
- W2314151648 cites W2126855107 @default.
- W2314151648 cites W2149705198 @default.
- W2314151648 cites W2153079669 @default.
- W2314151648 cites W2153998371 @default.
- W2314151648 cites W2154210976 @default.
- W2314151648 cites W2155584094 @default.
- W2314151648 cites W2158090607 @default.
- W2314151648 cites W2160202859 @default.
- W2314151648 cites W2164918702 @default.
- W2314151648 cites W2166433383 @default.
- W2314151648 cites W2173507839 @default.
- W2314151648 cites W2395825183 @default.
- W2314151648 cites W2501066993 @default.
- W2314151648 cites W48031782 @default.
- W2314151648 doi "https://doi.org/10.1177/0333102412461890" @default.
- W2314151648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23053304" @default.
- W2314151648 hasPublicationYear "2012" @default.
- W2314151648 type Work @default.
- W2314151648 sameAs 2314151648 @default.
- W2314151648 citedByCount "37" @default.
- W2314151648 countsByYear W23141516482013 @default.
- W2314151648 countsByYear W23141516482014 @default.
- W2314151648 countsByYear W23141516482015 @default.
- W2314151648 countsByYear W23141516482016 @default.
- W2314151648 countsByYear W23141516482017 @default.
- W2314151648 countsByYear W23141516482018 @default.
- W2314151648 countsByYear W23141516482019 @default.
- W2314151648 countsByYear W23141516482020 @default.
- W2314151648 countsByYear W23141516482021 @default.
- W2314151648 countsByYear W23141516482022 @default.
- W2314151648 countsByYear W23141516482023 @default.
- W2314151648 crossrefType "journal-article" @default.
- W2314151648 hasAuthorship W2314151648A5001876336 @default.
- W2314151648 hasAuthorship W2314151648A5007756770 @default.
- W2314151648 hasAuthorship W2314151648A5010978409 @default.
- W2314151648 hasAuthorship W2314151648A5039705796 @default.
- W2314151648 hasAuthorship W2314151648A5052410051 @default.
- W2314151648 hasAuthorship W2314151648A5057559893 @default.
- W2314151648 hasAuthorship W2314151648A5068237948 @default.
- W2314151648 hasAuthorship W2314151648A5080020006 @default.
- W2314151648 hasAuthorship W2314151648A5080500923 @default.
- W2314151648 hasConcept C118552586 @default.
- W2314151648 hasConcept C126322002 @default.
- W2314151648 hasConcept C161941745 @default.
- W2314151648 hasConcept C172497186 @default.
- W2314151648 hasConcept C203014093 @default.
- W2314151648 hasConcept C2776217527 @default.
- W2314151648 hasConcept C2776552330 @default.