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• W2314166621 abstract "Sir: I was pleased to read the article entitled “A Novel Murine Model of Hypertrophic Scarring Using Subcutaneous Infusion of Bleomycin” (Plast Reconstr Surg. 2014;133:69–78). This article focused on an animal model of hypertrophic scarring. The authors created the methods about bleomycin infusion for stimulating dermal fibroproliferation and building reproducible murine scars. They also analyzed histologic features and collagen content and organization, transforming growth factor-β, and cellularity for this model tissue. They concluded that the bleomycin model represents a promising technique for studying scar formation and testing new antiscarring therapies. According to the information from this article, I think this model has not solved the root of the problem about the hypertrophic scar model. As you know, apart from the animal model mentioned in this article, some other animal models can also produce the hypertropic scar and meet all of the characteristics of fibroblasts and tissue of scar collagen hypertrophy, for example, the nude mouse model1 and the rabbit ear model.2 This model does not have unique advantages compared with the other models published before. It was not perfect, and although it suggests a new method for a hypertrophic scar model, there exists a serious problem. As we all know, hypertrophic scarring is a genetic disease with different incidence rates and different susceptibilities in different human races, different families, and different individuals. Thus, the ideal model should reflect genetic characteristic of human hypertrophic scars to some extent, which is the key to the perfect animal model. It is very difficult to find a perfect animal model that includes the genetic characteristic. Without genetic characteristic of human hypertrophic scars, no model can provide precise results for a study of hypertrophic scarring. Like the animal models published before, this model does not reflect the genetic characteristics of hypertrophic scars and does not include any information regarding the genetic characteristics of scars. Nevertheless, this model does not give any consideration regarding this important factor. Therefore, I think this model may be no more significant in the area of hypertrophic scar research than other animal models before. DISCLOSURE The author has no financial interest to declare in relation to the content of this communication. Zhibo Xiao, Ph.D. Department of Plastic Surgery The Second Hospital of Harbin Medical University 194 Xuefu Road Harbin, People’s Republic of China 150086 [email protected]" @default.
• W2314166621 created "2016-06-24" @default.
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• W2314166621 date "2014-09-01" @default.
• W2314166621 modified "2023-09-26" @default.
• W2314166621 title "A Novel Murine Model of Hypertrophic Scarring Using Subcutaneous Infusion of Bleomycin" @default.
• W2314166621 cites W1895645464 @default.
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• W2314166621 doi "https://doi.org/10.1097/prs.0000000000000480" @default.
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