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- W2314227541 abstract "A hitherto unknown synergism exerted by vitamin A (retinol, retinal, retinoic acid) and vitamin C (L-ascorbic acid) was discovered using endothelial cells. Vitamin A alone stimulated the extracellular and intracellular activities of plasminogen activator up to 8- and 4-fold from control values, respectively. Vitamin C alone enhanced the extracellular and intracellular activities up to approximately 1.5-fold. It was, however, demonstrated that their effects on extracellular activity were synergistic: simultaneous administration of these two vitamins enhanced the extracellular activity up to a 20- to 50-fold. Increase of plasminogen activator activity induced with these vitamins was inhibited by a protein synthesis inhibitor, cycloheximide." @default.
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- W2314227541 date "1986-01-01" @default.
- W2314227541 modified "2023-09-27" @default.
- W2314227541 title "Induction of fibrinolysis by synergism of vitamins A and C." @default.
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- W2314227541 doi "https://doi.org/10.2491/jjsth1970.17.377" @default.
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