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• W2314228285 abstract "Amac: Bu calismada klinigimizde ameliyat edilen Marfan sendromlu hastalarin erken ve gec donem sonuclari icin risk faktorleri analiz edildi. Ca­lis­ma­pla­ni:­Subat 1987 Ekim 2008 tarihleri arasinda klinigimizde Marfan sendromlu 62 hasta (45 erkek 17 kadin; ort. yas 31.5±9.9 yil; dagilim 11-56 yil) ameliyat edildi. Bu hastalara toplam 90 cerrahi islem uygulandi. Cerrahinin sagkalim uzerindeki etkisini degerlendirmek amaciyla, bu risk faktorlerinin tek degiskenli ve cok degiskenli analizleri yapildi. Bul gu lar: Ortalama takip suresi 7.9±4.2 (dagilim 0.217.4) yil olup, toplam 471.2 hasta/yil idi. Iki hastada (%3.2) erken mortalite bildirildi. Bir, alti ve 15 yillik sagkalim oranlari sirasiyla, %96.8±2.2, %94.4±3.2 ve %87.1±5.8 idi. Hicbir risk faktoru erken mortalite ile anlamli duzeyde iliskili bulunmadi. Gec mortalite icin yapilan tek degiskenli analizde, acil ameliyat ve tekrar ameliyat mortalite ile iliskili bulunurken, cok degiskenli analizde yalnizca acil ameliyat mortalite icin anlamli bir risk faktoruydu. Yeni anevrizma ve diseksiyon gelisimi ile mitral yetmezlik olmadan 15. yilda sagkalim orani, sirasiyla %73.5±9.7, %93.2±4.9 ve %87.3±8.7 idi. So­nuc:­Calisma sonuclarimiz, cerrahi tedavi ile sagkalimda iyilesme oldugunu gostermekle birlikte, acil ameliyata alinan hastalarin yasam beklentisinde dusus oldugunu gostermistir. Bu nedenle, Marfan sendromlu hastalar kardiyovaskuler tutulum acisindan dikkatle izlenmelidir. Anah tar soz cuk ler: Gec donem sonuclar; Marfan sendromu; cerrahi. Background:­In this study, we analyzed the risk factors for early and late results in the patients with Marfan syndrome who underwent surgery in our clinic. Methods: Between February 1987 and October 2008, 62 patients with Marfan syndrome (45 males, 17 females; mean age 31.5±9.9 years; range 11 to 56 years) underwent surgery. A total of 90 surgical interventions were performed on these patients. Univariate and multivariate analyses of the risk factors were performed to evaluate the effect of these interventions on survival. Results:­ Mean follow-up was 7.9±4.2 (range 0.2 to 17.4) years, giving a total follow-up of 471.2 patient/years. Early mortality was reported in two of the patients (3.2%). Survival rates at one, six and 15 years were 96.8±2.2%, 94.4±3.2% and 87.1±5.8%, respectively. None of the risk factors were significantly associated with the early mortality. Univariate analysis of risk factors showed that emergency surgery and re-surgery were significantly associated with late mortality (p<0.05), whereas multivariate analysis demonstrated that only emergency surgery (p<0.05) was significantly associated with late mortality. At 15 years, new aneursym, dissection-free and mitral regurgitation-free survival rates were 73.5±9.7%, 93.2±4.9%, 87.3±8.7%, respectively. Conclusion:­Our study results suggested improved survival associated with surgical intervention, while showing reduced life expectancy in the patients with Marfan syndrome who underwent emergency surgery. Therefore, those patients should be monitored for cardiovascular involvement carefully." @default.
• W2314228285 created "2016-06-24" @default.
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• W2314228285 date "2012-01-05" @default.
• W2314228285 modified "2023-09-26" @default.
• W2314228285 title "Cardiovascular interventions in Marfan syndrome: the early and late results" @default.
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• W2314228285 doi "https://doi.org/10.5606/gkdc.dergisi.2012.003" @default.
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