Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314241902> ?p ?o ?g. }
- W2314241902 endingPage "506" @default.
- W2314241902 startingPage "498" @default.
- W2314241902 abstract "Background:Bisphenol A (BPA) is an endocrine disruptor and potential reproductive toxicant, but results of epidemiologic studies have been mixed and have been criticized for inadequate exposure assessment that often relies on a single measurement.Objective:Our goal was to describe the distribution of BPA concentrations in serial urinary specimens, assess temporal variability, and provide estimates of exposure classification when randomly selected samples are used to predict average exposure.Methods:We collected and analyzed 2,614 urine specimens from 83 Utah couples beginning in 2012. Female participants collected daily first-morning urine specimens during one to two menstrual cycles and male partners collected specimens during the woman’s fertile window for each cycle. We measured urinary BPA concentrations and calculated geometric means (GM) for each cycle, characterized the distribution of observed values and temporal variability using intraclass correlation coefficients, and performed surrogate category analyses to determine how well repeat samples could classify exposure.Results:The GM urine BPA concentration was 2.78 ng/mL among males and 2.44 ng/mL among females. BPA had a high degree of variability among both males (ICC = 0.18; 95% CI: 0.11, 0.26) and females (ICC = 0.11; 95% CI: 0.08, 0.16). Based on our more stringent surrogate category analysis, to reach proportions ≥ 0.80 for sensitivity, specificity, and positive predictive value (PPV) among females, 6 and 10 repeat samples for the high and low tertiles, respectively, were required. For the medium tertile, specificity reached 0.87 with 10 repeat samples, but even with 11 samples, sensitivity and PPV did not exceed 0.36. Five repeat samples, among males, yielded sensitivity and PPV values ≥ 0.75 for the high and low tertiles, but, similar to females, classification for the medium tertile was less accurate.Conclusion:Repeated urinary specimens are required to characterize typical BPA exposure.Citation:Cox KJ, Porucznik CA, Anderson DJ, Brozek EM, Szczotka KM, Bailey NM, Wilkins DG, Stanford JB. 2016. Exposure classification and temporal variability in urinary bisphenol A concentrations among couples in Utah—the HOPE study. Environ Health Perspect 124:498–506; http://dx.doi.org/10.1289/ehp.1509752" @default.
- W2314241902 created "2016-06-24" @default.
- W2314241902 creator A5059350673 @default.
- W2314241902 creator A5061041365 @default.
- W2314241902 creator A5065702018 @default.
- W2314241902 creator A5066398916 @default.
- W2314241902 creator A5073992167 @default.
- W2314241902 creator A5077756012 @default.
- W2314241902 creator A5083152429 @default.
- W2314241902 creator A5084096681 @default.
- W2314241902 date "2016-04-01" @default.
- W2314241902 modified "2023-10-16" @default.
- W2314241902 title "Exposure Classification and Temporal Variability in Urinary Bisphenol A Concentrations among Couples in Utah—The HOPE Study" @default.
- W2314241902 cites W1951670987 @default.
- W2314241902 cites W1975752932 @default.
- W2314241902 cites W1977726417 @default.
- W2314241902 cites W1982404766 @default.
- W2314241902 cites W1986951035 @default.
- W2314241902 cites W1988194549 @default.
- W2314241902 cites W2005427388 @default.
- W2314241902 cites W2005531169 @default.
- W2314241902 cites W2006759955 @default.
- W2314241902 cites W2015535652 @default.
- W2314241902 cites W2016709601 @default.
- W2314241902 cites W2035419367 @default.
- W2314241902 cites W2037428855 @default.
- W2314241902 cites W2037728383 @default.
- W2314241902 cites W2045123003 @default.
- W2314241902 cites W2050657448 @default.
- W2314241902 cites W2056276158 @default.
- W2314241902 cites W2057339074 @default.
- W2314241902 cites W2059263628 @default.
- W2314241902 cites W2059905660 @default.
- W2314241902 cites W2061365680 @default.
- W2314241902 cites W2061933800 @default.
- W2314241902 cites W2063517792 @default.
- W2314241902 cites W2064423615 @default.
- W2314241902 cites W2067256255 @default.
- W2314241902 cites W2067753015 @default.
- W2314241902 cites W2069914966 @default.
- W2314241902 cites W2087175878 @default.
- W2314241902 cites W2087324470 @default.
- W2314241902 cites W2089278924 @default.
- W2314241902 cites W2089588218 @default.
- W2314241902 cites W2090601295 @default.
- W2314241902 cites W2108116137 @default.
- W2314241902 cites W2117843333 @default.
- W2314241902 cites W2121036241 @default.
- W2314241902 cites W2148803336 @default.
- W2314241902 cites W2151355547 @default.
- W2314241902 cites W2252652140 @default.
- W2314241902 doi "https://doi.org/10.1289/ehp.1509752" @default.
- W2314241902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4829981" @default.
- W2314241902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26372668" @default.
- W2314241902 hasPublicationYear "2016" @default.
- W2314241902 type Work @default.
- W2314241902 sameAs 2314241902 @default.
- W2314241902 citedByCount "28" @default.
- W2314241902 countsByYear W23142419022016 @default.
- W2314241902 countsByYear W23142419022017 @default.
- W2314241902 countsByYear W23142419022018 @default.
- W2314241902 countsByYear W23142419022019 @default.
- W2314241902 countsByYear W23142419022020 @default.
- W2314241902 countsByYear W23142419022021 @default.
- W2314241902 countsByYear W23142419022022 @default.
- W2314241902 countsByYear W23142419022023 @default.
- W2314241902 crossrefType "journal-article" @default.
- W2314241902 hasAuthorship W2314241902A5059350673 @default.
- W2314241902 hasAuthorship W2314241902A5061041365 @default.
- W2314241902 hasAuthorship W2314241902A5065702018 @default.
- W2314241902 hasAuthorship W2314241902A5066398916 @default.
- W2314241902 hasAuthorship W2314241902A5073992167 @default.
- W2314241902 hasAuthorship W2314241902A5077756012 @default.
- W2314241902 hasAuthorship W2314241902A5083152429 @default.
- W2314241902 hasAuthorship W2314241902A5084096681 @default.
- W2314241902 hasBestOaLocation W23142419021 @default.
- W2314241902 hasConcept C104709138 @default.
- W2314241902 hasConcept C126322002 @default.
- W2314241902 hasConcept C140793950 @default.
- W2314241902 hasConcept C171606756 @default.
- W2314241902 hasConcept C19720800 @default.
- W2314241902 hasConcept C2779058012 @default.
- W2314241902 hasConcept C2780026642 @default.
- W2314241902 hasConcept C2780473477 @default.
- W2314241902 hasConcept C2780862370 @default.
- W2314241902 hasConcept C29730261 @default.
- W2314241902 hasConcept C42407357 @default.
- W2314241902 hasConcept C46699223 @default.
- W2314241902 hasConcept C70410870 @default.
- W2314241902 hasConcept C71315377 @default.
- W2314241902 hasConcept C71924100 @default.
- W2314241902 hasConcept C77411442 @default.
- W2314241902 hasConcept C86803240 @default.
- W2314241902 hasConceptScore W2314241902C104709138 @default.
- W2314241902 hasConceptScore W2314241902C126322002 @default.
- W2314241902 hasConceptScore W2314241902C140793950 @default.
- W2314241902 hasConceptScore W2314241902C171606756 @default.
- W2314241902 hasConceptScore W2314241902C19720800 @default.