FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314242745> ?p ?o ?g. }

• W2314242745 endingPage "484" @default.
• W2314242745 startingPage "472" @default.
• W2314242745 abstract "A library of 112 4(5)-aryl-2-amino-1H-imidazoles, 4,5-diphenyl-2-amino-1H-imidazoles, and N1-substituted 4(5)-phenyl-2-aminoimidazoles was synthesized and tested for the antagonistic effect against biofilm formation by Salmonella Typhimurium and Pseudomonas aeruginosa. The substitution pattern of the 4(5)-phenyl group and the nature of the N1-substituent were found to have a major effect on the biofilm inhibitory activity. The most active compounds of this series were shown to inhibit the biofilm formation at low micromolar concentrations. Furthermore, the influence of 6 imidazo[1,2-a]pyrimidines and 18 imidazo[1,2-a]pyrimidinium salts on the biofilm formation was tested. These compounds are the chemical precursors of the 2-aminoimidazoles in our synthesis pathway. A good correlation was found between the activity of the imidazo[1,2-a]pyrimidinium salts and their corresponding 2-aminoimidazoles, supporting the hypothesis that the imidazo[1,2-a]pyrimidinium salts are possibly cleaved by cellular nucleophiles to form the active 2-aminoimidazoles. However, the imidazo[1,2-a]pyrimidines did not show any biofilm inhibitory activity, indicating that these molecules are not susceptible to in situ degradation to 2-aminoimidazoles. Finally, we demonstrated the lack of biofilm inhibitory activity of an array of 37 2N-substituted 2-aminopyrimidines, which are the chemical precursors of the imidazo[1,2-a]pyrimidinium salts in our synthesis pathway." @default.
• W2314242745 created "2016-06-24" @default.
• W2314242745 creator A5004961522 @default.
• W2314242745 creator A5015077557 @default.
• W2314242745 creator A5015362394 @default.
• W2314242745 creator A5023256816 @default.
• W2314242745 creator A5035266471 @default.
• W2314242745 creator A5039474530 @default.
• W2314242745 creator A5053707446 @default.
• W2314242745 creator A5064220859 @default.
• W2314242745 creator A5077238999 @default.
• W2314242745 creator A5090352445 @default.
• W2314242745 date "2010-12-20" @default.
• W2314242745 modified "2023-09-27" @default.
• W2314242745 title "Structure−Activity Relationship of 4(5)-Aryl-2-amino-1<i>H</i>-imidazoles, <i>N</i>1-Substituted 2-Aminoimidazoles and Imidazo[1,2-<i>a</i>]pyrimidinium Salts as Inhibitors of Biofilm Formation by <i>Salmonella</i> Typhimurium and <i>Pseudomonas aeruginosa</i>" @default.
• W2314242745 cites W1947077987 @default.
• W2314242745 cites W1966541054 @default.
• W2314242745 cites W1969633868 @default.
• W2314242745 cites W1972604179 @default.
• W2314242745 cites W1989023405 @default.
• W2314242745 cites W1995018247 @default.
• W2314242745 cites W2005542799 @default.
• W2314242745 cites W2013442653 @default.
• W2314242745 cites W2015007070 @default.
• W2314242745 cites W2024534479 @default.
• W2314242745 cites W2030956160 @default.
• W2314242745 cites W2035856903 @default.
• W2314242745 cites W2038764969 @default.
• W2314242745 cites W2038814936 @default.
• W2314242745 cites W2040014098 @default.
• W2314242745 cites W2042500078 @default.
• W2314242745 cites W2054371239 @default.
• W2314242745 cites W2064858146 @default.
• W2314242745 cites W2066129380 @default.
• W2314242745 cites W2080936059 @default.
• W2314242745 cites W2083456954 @default.
• W2314242745 cites W2106103791 @default.
• W2314242745 cites W2107140594 @default.
• W2314242745 cites W2114923482 @default.
• W2314242745 cites W2125603952 @default.
• W2314242745 cites W2127354138 @default.
• W2314242745 cites W2127780357 @default.
• W2314242745 cites W2131727615 @default.
• W2314242745 cites W2133514339 @default.
• W2314242745 cites W2136518382 @default.
• W2314242745 cites W2144440398 @default.
• W2314242745 cites W2149116450 @default.
• W2314242745 cites W2149886824 @default.
• W2314242745 cites W2153666319 @default.
• W2314242745 cites W2169545551 @default.
• W2314242745 cites W2171939089 @default.
• W2314242745 cites W2313752598 @default.
• W2314242745 cites W2949677830 @default.
• W2314242745 cites W2950341221 @default.
• W2314242745 cites W4213354399 @default.
• W2314242745 doi "https://doi.org/10.1021/jm1011148" @default.
• W2314242745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21174477" @default.
• W2314242745 hasPublicationYear "2010" @default.
• W2314242745 type Work @default.
• W2314242745 sameAs 2314242745 @default.
• W2314242745 citedByCount "51" @default.
• W2314242745 countsByYear W23142427452012 @default.
• W2314242745 countsByYear W23142427452013 @default.
• W2314242745 countsByYear W23142427452014 @default.
• W2314242745 countsByYear W23142427452015 @default.
• W2314242745 countsByYear W23142427452016 @default.
• W2314242745 countsByYear W23142427452017 @default.
• W2314242745 countsByYear W23142427452018 @default.
• W2314242745 countsByYear W23142427452019 @default.
• W2314242745 countsByYear W23142427452020 @default.
• W2314242745 countsByYear W23142427452021 @default.
• W2314242745 countsByYear W23142427452022 @default.
• W2314242745 crossrefType "journal-article" @default.
• W2314242745 hasAuthorship W2314242745A5004961522 @default.
• W2314242745 hasAuthorship W2314242745A5015077557 @default.
• W2314242745 hasAuthorship W2314242745A5015362394 @default.
• W2314242745 hasAuthorship W2314242745A5023256816 @default.
• W2314242745 hasAuthorship W2314242745A5035266471 @default.
• W2314242745 hasAuthorship W2314242745A5039474530 @default.
• W2314242745 hasAuthorship W2314242745A5053707446 @default.
• W2314242745 hasAuthorship W2314242745A5064220859 @default.
• W2314242745 hasAuthorship W2314242745A5077238999 @default.
• W2314242745 hasAuthorship W2314242745A5090352445 @default.
• W2314242745 hasConcept C155647269 @default.
• W2314242745 hasConcept C161790260 @default.
• W2314242745 hasConcept C178790620 @default.
• W2314242745 hasConcept C178907741 @default.
• W2314242745 hasConcept C185592680 @default.
• W2314242745 hasConcept C193042331 @default.
• W2314242745 hasConcept C202751555 @default.
• W2314242745 hasConcept C2777752112 @default.
• W2314242745 hasConcept C2778689049 @default.
• W2314242745 hasConcept C2780263894 @default.
• W2314242745 hasConcept C2781076698 @default.
• W2314242745 hasConcept C523546767 @default.
• W2314242745 hasConcept C54355233 @default.
• W2314242745 hasConcept C55493867 @default.
• W2314242745 hasConcept C58123911 @default.

• next