FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314243707> ?p ?o ?g. }

• W2314243707 endingPage "3109" @default.
• W2314243707 startingPage "3100" @default.
• W2314243707 abstract "We have shown previously that the bleomycin (BLM) carbohydrate moiety can recapitulate the tumor cell targeting effects of the entire BLM molecule, that BLM itself is modular in nature consisting of a DNA-cleaving aglycone which is delivered selectively to the interior of tumor cells by its carbohydrate moiety, and that there are disaccharides structurally related to the BLM disaccharide which are more efficient than the natural disaccharide at tumor cell targeting/uptake. Because BLM sugars can deliver molecular cargoes selectively to tumor cells, and thus potentially form the basis for a novel antitumor strategy, it seemed important to consider additional structural features capable of affecting the efficiency of tumor cell recognition and delivery. These included the effects of sugar polyvalency and net charge (at physiological pH) on tumor cell recognition, internalization, and trafficking. Since these parameters have been shown to affect cell surface recognition, internalization, and distribution in other contexts, this study has sought to define the effects of these structural features on tumor cell recognition by bleomycin and its disaccharide. We demonstrate that both can have a significant effect on tumor cell binding/internalization, and present data which suggests that the metal ions normally bound by bleomycin following clinical administration may significantly contribute to the efficiency of tumor cell uptake, in addition to their characterized function in DNA cleavage. A BLM disaccharide-Cy5** conjugate incorporating the positively charged dipeptide d-Lys-d-Lys was found to associate with both the mitochondria and the nuclear envelope of DU145 cells, suggesting possible cellular targets for BLM disaccharide-cytotoxin conjugates." @default.
• W2314243707 created "2016-06-24" @default.
• W2314243707 creator A5006249781 @default.
• W2314243707 creator A5020309791 @default.
• W2314243707 creator A5024557017 @default.
• W2314243707 creator A5028006946 @default.
• W2314243707 creator A5050706812 @default.
• W2314243707 creator A5052113690 @default.
• W2314243707 date "2015-05-06" @default.
• W2314243707 modified "2023-10-13" @default.
• W2314243707 title "Structural Features Facilitating Tumor Cell Targeting and Internalization by Bleomycin and Its Disaccharide" @default.
• W2314243707 cites W1516245939 @default.
• W2314243707 cites W1582647566 @default.
• W2314243707 cites W1827772136 @default.
• W2314243707 cites W1963766529 @default.
• W2314243707 cites W1963985871 @default.
• W2314243707 cites W1964138791 @default.
• W2314243707 cites W1968507131 @default.
• W2314243707 cites W1977943274 @default.
• W2314243707 cites W1980508011 @default.
• W2314243707 cites W1981153846 @default.
• W2314243707 cites W1986353574 @default.
• W2314243707 cites W1989013115 @default.
• W2314243707 cites W1989901526 @default.
• W2314243707 cites W1990821692 @default.
• W2314243707 cites W1991429659 @default.
• W2314243707 cites W1993944091 @default.
• W2314243707 cites W2004105273 @default.
• W2314243707 cites W2005613470 @default.
• W2314243707 cites W2009408082 @default.
• W2314243707 cites W2018682207 @default.
• W2314243707 cites W2020088400 @default.
• W2314243707 cites W2025375230 @default.
• W2314243707 cites W2028484290 @default.
• W2314243707 cites W2034198381 @default.
• W2314243707 cites W2037750278 @default.
• W2314243707 cites W2048832692 @default.
• W2314243707 cites W2050484074 @default.
• W2314243707 cites W2053464818 @default.
• W2314243707 cites W2054799935 @default.
• W2314243707 cites W2056304204 @default.
• W2314243707 cites W2072405958 @default.
• W2314243707 cites W2072636115 @default.
• W2314243707 cites W2075249158 @default.
• W2314243707 cites W2100132818 @default.
• W2314243707 cites W2109938472 @default.
• W2314243707 cites W2140014506 @default.
• W2314243707 cites W2147325553 @default.
• W2314243707 cites W2151195667 @default.
• W2314243707 cites W2156241187 @default.
• W2314243707 cites W2232684587 @default.
• W2314243707 cites W2319200467 @default.
• W2314243707 cites W2321232485 @default.
• W2314243707 cites W2334810522 @default.
• W2314243707 cites W24376670 @default.
• W2314243707 cites W2475110257 @default.
• W2314243707 cites W2949336829 @default.
• W2314243707 cites W4211015427 @default.
• W2314243707 cites W4238598813 @default.
• W2314243707 doi "https://doi.org/10.1021/acs.biochem.5b00277" @default.
• W2314243707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4440614" @default.
• W2314243707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25905565" @default.
• W2314243707 hasPublicationYear "2015" @default.
• W2314243707 type Work @default.
• W2314243707 sameAs 2314243707 @default.
• W2314243707 citedByCount "37" @default.
• W2314243707 countsByYear W23142437072015 @default.
• W2314243707 countsByYear W23142437072016 @default.
• W2314243707 countsByYear W23142437072017 @default.
• W2314243707 countsByYear W23142437072018 @default.
• W2314243707 countsByYear W23142437072020 @default.
• W2314243707 countsByYear W23142437072021 @default.
• W2314243707 countsByYear W23142437072022 @default.
• W2314243707 countsByYear W23142437072023 @default.
• W2314243707 crossrefType "journal-article" @default.
• W2314243707 hasAuthorship W2314243707A5006249781 @default.
• W2314243707 hasAuthorship W2314243707A5020309791 @default.
• W2314243707 hasAuthorship W2314243707A5024557017 @default.
• W2314243707 hasAuthorship W2314243707A5028006946 @default.
• W2314243707 hasAuthorship W2314243707A5050706812 @default.
• W2314243707 hasAuthorship W2314243707A5052113690 @default.
• W2314243707 hasBestOaLocation W23142437071 @default.
• W2314243707 hasConcept C12554922 @default.
• W2314243707 hasConcept C139770010 @default.
• W2314243707 hasConcept C1491633281 @default.
• W2314243707 hasConcept C185592680 @default.
• W2314243707 hasConcept C2776232574 @default.
• W2314243707 hasConcept C2776694085 @default.
• W2314243707 hasConcept C2777346074 @default.
• W2314243707 hasConcept C54355233 @default.
• W2314243707 hasConcept C55493867 @default.
• W2314243707 hasConcept C86803240 @default.
• W2314243707 hasConceptScore W2314243707C12554922 @default.
• W2314243707 hasConceptScore W2314243707C139770010 @default.
• W2314243707 hasConceptScore W2314243707C1491633281 @default.
• W2314243707 hasConceptScore W2314243707C185592680 @default.
• W2314243707 hasConceptScore W2314243707C2776232574 @default.
• W2314243707 hasConceptScore W2314243707C2776694085 @default.

• next