FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314297626> ?p ?o ?g. }

• W2314297626 endingPage "F594" @default.
• W2314297626 startingPage "F583" @default.
• W2314297626 abstract "When introduced clinically 6 years ago, renal denervation was thought to be the solution for all patients whose blood pressure could not be controlled by medication. The initial two studies, SYMPLICITY HTN-1 and HTN-2, demonstrated great magnitudes of blood pressure reduction within 6 mo of the procedure and were based on a number of assumptions that may not have been true, including strict adherence to medication and absence of white-coat hypertension. The SYMPLICITY HTN-3 trial controlled for all possible factors believed to influence the outcome, including the addition of a sham arm, and ultimately proved the demise of the initial overly optimistic expectations. This trial yielded a much lower blood pressure reduction compared with the previous SYMPLICITY trials. Since its publication in 2014, there have been many analyses to try and understand what accounted for the differences. Of all the variables examined that could influence blood pressure outcomes, the extent of the denervation procedure was determined to be inadequate. Beyond this, the physiological mechanisms that account for the heterogeneous fall in arterial pressure following renal denervation remain unclear, and experimental studies indicate dependence on more than simply reduced renal sympathetic activity. These and other related issues are discussed in this paper. Our perspective is that renal denervation works if done properly and used in the appropriate patient population. New studies with new approaches and catheters and appropriate controls will be starting later this year to reassess the efficacy and safety of renal denervation in humans." @default.
• W2314297626 created "2016-06-24" @default.
• W2314297626 creator A5012514694 @default.
• W2314297626 creator A5025753116 @default.
• W2314297626 creator A5045876577 @default.
• W2314297626 creator A5082009722 @default.
• W2314297626 creator A5085524593 @default.
• W2314297626 date "2015-10-01" @default.
• W2314297626 modified "2023-10-17" @default.
• W2314297626 title "Renal denervation for the treatment of resistant hypertension: review and clinical perspective" @default.
• W2314297626 cites W1583834060 @default.
• W2314297626 cites W1963919923 @default.
• W2314297626 cites W1970795962 @default.
• W2314297626 cites W1972278199 @default.
• W2314297626 cites W1972611908 @default.
• W2314297626 cites W1974062105 @default.
• W2314297626 cites W1976176977 @default.
• W2314297626 cites W1976289196 @default.
• W2314297626 cites W1978578097 @default.
• W2314297626 cites W1984845078 @default.
• W2314297626 cites W1992123574 @default.
• W2314297626 cites W1994487234 @default.
• W2314297626 cites W1997818070 @default.
• W2314297626 cites W2002349269 @default.
• W2314297626 cites W2010799694 @default.
• W2314297626 cites W2019775471 @default.
• W2314297626 cites W2020837583 @default.
• W2314297626 cites W2035261421 @default.
• W2314297626 cites W2039202404 @default.
• W2314297626 cites W2040285032 @default.
• W2314297626 cites W2057163291 @default.
• W2314297626 cites W2059519099 @default.
• W2314297626 cites W2073133651 @default.
• W2314297626 cites W2077619385 @default.
• W2314297626 cites W2077782630 @default.
• W2314297626 cites W2088257585 @default.
• W2314297626 cites W2090790150 @default.
• W2314297626 cites W2091660015 @default.
• W2314297626 cites W2097213658 @default.
• W2314297626 cites W2100255850 @default.
• W2314297626 cites W2102620697 @default.
• W2314297626 cites W2104599770 @default.
• W2314297626 cites W2104804571 @default.
• W2314297626 cites W2109625017 @default.
• W2314297626 cites W2109876426 @default.
• W2314297626 cites W2110123557 @default.
• W2314297626 cites W2112154387 @default.
• W2314297626 cites W2114707939 @default.
• W2314297626 cites W2115136352 @default.
• W2314297626 cites W2115461708 @default.
• W2314297626 cites W2117197375 @default.
• W2314297626 cites W2118344567 @default.
• W2314297626 cites W2121399343 @default.
• W2314297626 cites W2121735148 @default.
• W2314297626 cites W2122915712 @default.
• W2314297626 cites W2124171699 @default.
• W2314297626 cites W2125860999 @default.
• W2314297626 cites W2129695314 @default.
• W2314297626 cites W2133088349 @default.
• W2314297626 cites W2136971934 @default.
• W2314297626 cites W2140070979 @default.
• W2314297626 cites W2144176248 @default.
• W2314297626 cites W2147167641 @default.
• W2314297626 cites W2148827677 @default.
• W2314297626 cites W2149134843 @default.
• W2314297626 cites W2149702334 @default.
• W2314297626 cites W2150734413 @default.
• W2314297626 cites W2151009383 @default.
• W2314297626 cites W2151173810 @default.
• W2314297626 cites W2154059912 @default.
• W2314297626 cites W2155340986 @default.
• W2314297626 cites W2155568433 @default.
• W2314297626 cites W2158093616 @default.
• W2314297626 cites W2158591578 @default.
• W2314297626 cites W2160617287 @default.
• W2314297626 cites W2160704477 @default.
• W2314297626 cites W2161808916 @default.
• W2314297626 cites W2163665839 @default.
• W2314297626 cites W2166344703 @default.
• W2314297626 cites W2170587834 @default.
• W2314297626 cites W2172086404 @default.
• W2314297626 cites W2275546552 @default.
• W2314297626 cites W2305899748 @default.
• W2314297626 cites W2312568090 @default.
• W2314297626 cites W2318930512 @default.
• W2314297626 cites W2346030280 @default.
• W2314297626 cites W2402950024 @default.
• W2314297626 cites W2403264650 @default.
• W2314297626 cites W2409859869 @default.
• W2314297626 cites W2434303831 @default.
• W2314297626 cites W2467042522 @default.
• W2314297626 cites W2477567742 @default.
• W2314297626 cites W2600388038 @default.
• W2314297626 cites W4205373146 @default.
• W2314297626 cites W75245760 @default.
• W2314297626 doi "https://doi.org/10.1152/ajprenal.00246.2015" @default.
• W2314297626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4593817" @default.
• W2314297626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26224718" @default.

• next