Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314299968> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2314299968 endingPage "616" @default.
- W2314299968 startingPage "607" @default.
- W2314299968 abstract "A new hypnotic, 450191-S, is a ring-opened benzodiazepine derivative. It is knownthat the unchanged drug is not detected in plasma and urine after oral administration ofthis drug to humans, and that the metabolites of 450191-S, M-1, M-2, M-A, M-3, and M-4are found in plasma and mainly M-4 is excreted in urine. Some papers have shown thatthe main active metabolites of 450191-S are M-1, M-2, M-A, and M-3.This paper deals with the pharmacokinetics of 450191-S in healthy volunteers . Plasmahalf-lives of metabolites of 450191-S were M-1, 1.2±0.5hr;M-2, 3.2±0.8hr;M-A, 5.0±1.2hr;M-3, 8.5±1.Ohr;and M-4, 1.7±0.1hr (mean±SD).The half-life of total activemetabolites (the sum of the plasma concentration of M-1, M-2, M-A, and M-3) was 10.5±2.6hr.Plasma concentration of each metabolite after administration of 0.5, 1, 2, 4mgof 450191-S was approximately proportional to the dose. Mean urinary excretion ratio of M-4 was 62. 3% of the dose. Effect of food on the pharmacokinetic parameters was notfound. Plasma concentration of each metabolite after multiple administration showed asimilar time course to the simulation curve calculated using pharmacokinetic parametersestimated from observed plasma concentrations after the first dose. Plasma protein binding ratios measured by ultrafiltration at 37° were M-1, 79.3%;M-2, 81.2-87.5%;M-A, 76.8-78.7%;M-3, 80.8-81.4%;and M-4, 88.9-89.7%." @default.
- W2314299968 created "2016-06-24" @default.
- W2314299968 creator A5000765342 @default.
- W2314299968 creator A5028421957 @default.
- W2314299968 creator A5028974310 @default.
- W2314299968 creator A5029185764 @default.
- W2314299968 creator A5035706433 @default.
- W2314299968 creator A5054872094 @default.
- W2314299968 creator A5066033343 @default.
- W2314299968 creator A5088629905 @default.
- W2314299968 creator A5091275866 @default.
- W2314299968 creator A5045111463 @default.
- W2314299968 date "1988-01-01" @default.
- W2314299968 modified "2023-10-02" @default.
- W2314299968 title "Pharmacokinetics of a novel hypnotic, 450191-S in healthy volunteers." @default.
- W2314299968 cites W1966604603 @default.
- W2314299968 cites W1976681023 @default.
- W2314299968 cites W2025155208 @default.
- W2314299968 cites W2513969377 @default.
- W2314299968 doi "https://doi.org/10.3999/jscpt.19.607" @default.
- W2314299968 hasPublicationYear "1988" @default.
- W2314299968 type Work @default.
- W2314299968 sameAs 2314299968 @default.
- W2314299968 citedByCount "2" @default.
- W2314299968 crossrefType "journal-article" @default.
- W2314299968 hasAuthorship W2314299968A5000765342 @default.
- W2314299968 hasAuthorship W2314299968A5028421957 @default.
- W2314299968 hasAuthorship W2314299968A5028974310 @default.
- W2314299968 hasAuthorship W2314299968A5029185764 @default.
- W2314299968 hasAuthorship W2314299968A5035706433 @default.
- W2314299968 hasAuthorship W2314299968A5045111463 @default.
- W2314299968 hasAuthorship W2314299968A5054872094 @default.
- W2314299968 hasAuthorship W2314299968A5066033343 @default.
- W2314299968 hasAuthorship W2314299968A5088629905 @default.
- W2314299968 hasAuthorship W2314299968A5091275866 @default.
- W2314299968 hasBestOaLocation W23142999681 @default.
- W2314299968 hasConcept C112705442 @default.
- W2314299968 hasConcept C149151106 @default.
- W2314299968 hasConcept C185592680 @default.
- W2314299968 hasConcept C2777477808 @default.
- W2314299968 hasConcept C2780026642 @default.
- W2314299968 hasConcept C2780930544 @default.
- W2314299968 hasConcept C3020079912 @default.
- W2314299968 hasConcept C3941253 @default.
- W2314299968 hasConcept C43617362 @default.
- W2314299968 hasConcept C55493867 @default.
- W2314299968 hasConcept C71924100 @default.
- W2314299968 hasConcept C98274493 @default.
- W2314299968 hasConceptScore W2314299968C112705442 @default.
- W2314299968 hasConceptScore W2314299968C149151106 @default.
- W2314299968 hasConceptScore W2314299968C185592680 @default.
- W2314299968 hasConceptScore W2314299968C2777477808 @default.
- W2314299968 hasConceptScore W2314299968C2780026642 @default.
- W2314299968 hasConceptScore W2314299968C2780930544 @default.
- W2314299968 hasConceptScore W2314299968C3020079912 @default.
- W2314299968 hasConceptScore W2314299968C3941253 @default.
- W2314299968 hasConceptScore W2314299968C43617362 @default.
- W2314299968 hasConceptScore W2314299968C55493867 @default.
- W2314299968 hasConceptScore W2314299968C71924100 @default.
- W2314299968 hasConceptScore W2314299968C98274493 @default.
- W2314299968 hasIssue "3" @default.
- W2314299968 hasLocation W23142999681 @default.
- W2314299968 hasOpenAccess W2314299968 @default.
- W2314299968 hasPrimaryLocation W23142999681 @default.
- W2314299968 hasRelatedWork W1492229869 @default.
- W2314299968 hasRelatedWork W1964759623 @default.
- W2314299968 hasRelatedWork W1998356222 @default.
- W2314299968 hasRelatedWork W2000897105 @default.
- W2314299968 hasRelatedWork W2056938528 @default.
- W2314299968 hasRelatedWork W2132691174 @default.
- W2314299968 hasRelatedWork W2314299968 @default.
- W2314299968 hasRelatedWork W2379586841 @default.
- W2314299968 hasRelatedWork W2408027533 @default.
- W2314299968 hasRelatedWork W1924049245 @default.
- W2314299968 hasVolume "19" @default.
- W2314299968 isParatext "false" @default.
- W2314299968 isRetracted "false" @default.
- W2314299968 magId "2314299968" @default.
- W2314299968 workType "article" @default.