FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314332938> ?p ?o ?g. }

• W2314332938 abstract "You have accessJournal of UrologyKidney Cancer: Basic Research III1 Apr 2012437 GAIN OF CHROMOSOME 8Q IS ASSOCIATED WITH METASTASES AND POOR SURVIVAL OF PATIENTS WITH CLEAR CELL RENAL CELL CARCINOMA Tobias Klatte, Nils Kroeger, Edward Rampersaud, Frederic Birkhaeuser, Joshua Logan, Geoffrey Sonn, Joseph Riss, P. Nagesh Rao, Fairooz Kabbinavar, Arie Belldegrun, and Allan Pantuck Tobias KlatteTobias Klatte Los Angeles, CA More articles by this author , Nils KroegerNils Kroeger Los Angeles, CA More articles by this author , Edward RampersaudEdward Rampersaud Los Angeles, CA More articles by this author , Frederic BirkhaeuserFrederic Birkhaeuser Los Angeles, CA More articles by this author , Joshua LoganJoshua Logan Los Angeles, CA More articles by this author , Geoffrey SonnGeoffrey Sonn Los Angeles, CA More articles by this author , Joseph RissJoseph Riss Los Angeles, CA More articles by this author , P. Nagesh RaoP. Nagesh Rao Los Angeles, CA More articles by this author , Fairooz KabbinavarFairooz Kabbinavar Los Angeles, CA More articles by this author , Arie BelldegrunArie Belldegrun Los Angeles, CA More articles by this author , and Allan PantuckAllan Pantuck Los Angeles, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.504AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Chromosome 8q harbors the proto-oncogene c-myc, which may be upregulated through gain of 8q and subsequently alter tumor biology through the MAPK/ERK pathway. In several malignancies, gain of 8q has been identified as an adverse prognostic factor, but there is no data in clear cell renal cell carcinoma (CCRCC). The objective of this study was to evaluate the prevalence of 8q gain in CCRCC and to correlate the findings with pathological variables and disease-specific survival (DSS). METHODS We prospectively analyzed the karyotypes of 393 consecutive patients who underwent nephrectomy for CCRCC at UCLA. Viable tumor samples were collected immediately after surgery, short-term cultured, and then cytogenetically analyzed by using GPG banding. The 336 patients (85%) with abnormal karyotype represent the reported study cohort. Comparisons of categorical data were performed with chi-square tests. Univariable and multivariable Cox proportional hazards models addressed the impact of 8q gain on DSS. RESULTS Gain of 8q occurred in 28 tumors (8%). Twelve tumors (43%) had unbalanced translocations, which involved the chromosomes 3p (n=3), 3q (n=2), 16q (n=2), 1p (n=1), 2q (n=1), 14q (n=1), 15p (n=1), and 19q (n=1). In addition, 9 tumors (32%) showed trisomy 8, and 7 (25%) had i(8)(q10), which resulted in loss of 8p (pter-p10) and gain of 8q (q10-qter). Both gain of 8q and loss of 8p were found in 11 tumors (39%). Gain of 8q was associated with a higher risk of regional lymph node metastases (21% vs. 6%, p=0.003) and distant metastases (50% vs. 24%, p=0.003), while no association was found with T stage (p=0.076) or grade (p=0.785). Patients with gain of 8q had worse prognosis (p=0.0001), corresponding to a 3.22-fold (95% CI 1.76-5.89) increased risk of RCC-specific death. In multivariable analysis, TNM stage group (HR 3.88, p<0.001), Fuhrman grade (HR 1.80, p=0.006) and gain of 8q (HR 1.95, p=0.034) were identified as independent prognostic factors. CONCLUSIONS Gain of chromosome 8q occurs in a subset of CCRCCs and is associated with an increased risk of metastases and death from CCRCC. As the proto-oncogene c-myc is located on 8q, the current data suggest that tumors with gain of 8q and subsequent c-myc up-regulation may have unique molecular pathways activated, which are associated with an aggressive clinical phenotype. Defining tumors with gain of 8q may assist in identifying patients for specific c-myc inhibitors or agents targeting the MAPK/ERK pathway. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e179 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tobias Klatte Los Angeles, CA More articles by this author Nils Kroeger Los Angeles, CA More articles by this author Edward Rampersaud Los Angeles, CA More articles by this author Frederic Birkhaeuser Los Angeles, CA More articles by this author Joshua Logan Los Angeles, CA More articles by this author Geoffrey Sonn Los Angeles, CA More articles by this author Joseph Riss Los Angeles, CA More articles by this author P. Nagesh Rao Los Angeles, CA More articles by this author Fairooz Kabbinavar Los Angeles, CA More articles by this author Arie Belldegrun Los Angeles, CA More articles by this author Allan Pantuck Los Angeles, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2314332938 created "2016-06-24" @default.
• W2314332938 creator A5006496749 @default.
• W2314332938 creator A5013867374 @default.
• W2314332938 creator A5023716783 @default.
• W2314332938 creator A5025998645 @default.
• W2314332938 creator A5039495553 @default.
• W2314332938 creator A5044508814 @default.
• W2314332938 creator A5051120030 @default.
• W2314332938 creator A5056909405 @default.
• W2314332938 creator A5060752508 @default.
• W2314332938 creator A5069683592 @default.
• W2314332938 creator A5087799211 @default.
• W2314332938 date "2012-04-01" @default.
• W2314332938 modified "2023-09-25" @default.
• W2314332938 title "437 GAIN OF CHROMOSOME 8Q IS ASSOCIATED WITH METASTASES AND POOR SURVIVAL OF PATIENTS WITH CLEAR CELL RENAL CELL CARCINOMA" @default.
• W2314332938 cites W158083236 @default.
• W2314332938 cites W1914468689 @default.
• W2314332938 cites W1968938484 @default.
• W2314332938 cites W1988015039 @default.
• W2314332938 cites W1990095055 @default.
• W2314332938 cites W1998620943 @default.
• W2314332938 cites W2008516116 @default.
• W2314332938 cites W2010225305 @default.
• W2314332938 cites W2017884425 @default.
• W2314332938 cites W2029215616 @default.
• W2314332938 cites W2029975221 @default.
• W2314332938 cites W2030869361 @default.
• W2314332938 cites W2035226619 @default.
• W2314332938 cites W2039545078 @default.
• W2314332938 cites W2059170385 @default.
• W2314332938 cites W2061894086 @default.
• W2314332938 cites W2083887116 @default.
• W2314332938 cites W2096957390 @default.
• W2314332938 cites W2101879059 @default.
• W2314332938 cites W2104268794 @default.
• W2314332938 cites W2110380269 @default.
• W2314332938 cites W2122018421 @default.
• W2314332938 cites W2128320141 @default.
• W2314332938 cites W2136109165 @default.
• W2314332938 cites W2142630230 @default.
• W2314332938 cites W2144470771 @default.
• W2314332938 cites W2147752731 @default.
• W2314332938 cites W2158394122 @default.
• W2314332938 cites W2339359539 @default.
• W2314332938 doi "https://doi.org/10.1016/j.juro.2012.02.504" @default.
• W2314332938 hasPublicationYear "2012" @default.
• W2314332938 type Work @default.
• W2314332938 sameAs 2314332938 @default.
• W2314332938 citedByCount "0" @default.
• W2314332938 crossrefType "journal-article" @default.
• W2314332938 hasAuthorship W2314332938A5006496749 @default.
• W2314332938 hasAuthorship W2314332938A5013867374 @default.
• W2314332938 hasAuthorship W2314332938A5023716783 @default.
• W2314332938 hasAuthorship W2314332938A5025998645 @default.
• W2314332938 hasAuthorship W2314332938A5039495553 @default.
• W2314332938 hasAuthorship W2314332938A5044508814 @default.
• W2314332938 hasAuthorship W2314332938A5051120030 @default.
• W2314332938 hasAuthorship W2314332938A5056909405 @default.
• W2314332938 hasAuthorship W2314332938A5060752508 @default.
• W2314332938 hasAuthorship W2314332938A5069683592 @default.
• W2314332938 hasAuthorship W2314332938A5087799211 @default.
• W2314332938 hasConcept C104317684 @default.
• W2314332938 hasConcept C121608353 @default.
• W2314332938 hasConcept C126322002 @default.
• W2314332938 hasConcept C2777472916 @default.
• W2314332938 hasConcept C2781278892 @default.
• W2314332938 hasConcept C30481170 @default.
• W2314332938 hasConcept C502942594 @default.
• W2314332938 hasConcept C54355233 @default.
• W2314332938 hasConcept C71924100 @default.
• W2314332938 hasConcept C86803240 @default.
• W2314332938 hasConceptScore W2314332938C104317684 @default.
• W2314332938 hasConceptScore W2314332938C121608353 @default.
• W2314332938 hasConceptScore W2314332938C126322002 @default.
• W2314332938 hasConceptScore W2314332938C2777472916 @default.
• W2314332938 hasConceptScore W2314332938C2781278892 @default.
• W2314332938 hasConceptScore W2314332938C30481170 @default.
• W2314332938 hasConceptScore W2314332938C502942594 @default.
• W2314332938 hasConceptScore W2314332938C54355233 @default.
• W2314332938 hasConceptScore W2314332938C71924100 @default.
• W2314332938 hasConceptScore W2314332938C86803240 @default.
• W2314332938 hasIssue "4S" @default.
• W2314332938 hasLocation W23143329381 @default.
• W2314332938 hasOpenAccess W2314332938 @default.
• W2314332938 hasPrimaryLocation W23143329381 @default.
• W2314332938 hasRelatedWork W1997169225 @default.
• W2314332938 hasRelatedWork W2005149537 @default.
• W2314332938 hasRelatedWork W2096517981 @default.
• W2314332938 hasRelatedWork W2362434115 @default.
• W2314332938 hasRelatedWork W2416851953 @default.
• W2314332938 hasRelatedWork W2762568953 @default.
• W2314332938 hasRelatedWork W2968450929 @default.
• W2314332938 hasRelatedWork W3113261641 @default.
• W2314332938 hasRelatedWork W4210372902 @default.
• W2314332938 hasRelatedWork W4321444278 @default.
• W2314332938 hasVolume "187" @default.
• W2314332938 isParatext "false" @default.
• W2314332938 isRetracted "false" @default.
• W2314332938 magId "2314332938" @default.

• next