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- W2314333031 abstract "Objective. We sought to assess the long-term faith of migraine in patients with high risk anatomic and func- tional characteristics predisposing to paradoxical embolism submitted to patent foramen ovale (PFO) transcatheter closure. Methods. In a prospective single-center non randomized registry from January 2004 to January 2010 we enrolled 80 patients (58 female, mean age 42±2.7 years, 63 patients with aura) submitted to transcatheter PFO closure in our center. All patients fulfilled the following criteria: basal shunt and shower/curtain shunt pattern on transcranial Doppler and echocardiography, presence of interatrial septal aneurysm (ISA) and Eustachian valve, 3-4 class MIDAS score, coagulation abnormalities, medication-refractory migraine with or without aura. Migraine Disabil- ity Assessment Score (MIDAS) was used to assess the incidence and severity of migraine before and after mechani- cal closure. High risk features for paradoxical embolism included all of the following. Results. Percutaneous closure was successful in all cases (occlusion rate 91.2%), using a specifically anatomically-driven tailored strategy, with no peri-procedural or in-hospital complications; 70/80 of patients (87.5%) reported improved migraine symptomatology (mean MIDAS score decreased 33.4±6.7 to 10.6±9.8, p<0.03) whereas 12.5% reported no amelioration: none of the patients reported worsening of the previous migraine symptoms. Auras were definitively cured in 61/63 patients with migraine with aura (96.8%). Conclusions. Transcatheter PFO closure in a selected population of patients with severe migraine at high risk of paradoxical embolism resulted in a significant reduction in migraine over a long-term follow- up." @default.
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- W2314333031 date "2012-01-01" @default.
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- W2314333031 title "Original Article Improving migraine by means of primary transcatheter patent foramen ovale closure: long-term follow-up" @default.
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