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• W2314338399 abstract "Event Abstract Back to Event Age-related alterations in the long-term regulation of food intake and body weight Árpád O. Szabad1*, Andreas Schmidt1, Zsófia Barcza1, Márta Balaskó1 and Miklós Székely1 1 University of Pécs, Department of Pathophysiology and Gerontology, Medical School, Hungary Long-term regulation of energy balance is characterized by two major tendencies: weight gain of the middle-aged and later anorexia and consequent loss of active tissues, leading to sarcopenia of the old population. In the background of these alterations, complex age-related shifts in the activity of the hypothalamic catabolic and anabolic neurohumoral systems may be assumed. Anabolic substances increase body weight (BW) via enhancement of food intake (FI) and suppression of metabolic rate, while catabolic mediators act in an opposite way. Our aim was to study the central effects of catabolic alpha-melanocyte-stimulating hormone (α-MSH), catabolic corticotropin releasing factor (CRF), and of anabolic neuropeptide Y (NPY) on FI in different age-groups of rats. Male Wistar rats aged 6-weeks, 3-4-, 6-, 12-, 18- or 24-months represented the human juvenile, young adult, 2 middle-aged and 2 old groups, respectively. FI-values were measured in an automated Feedscale system (Colombus) following intracerebroventricular injections of α-MSH (5 µg), CRF (0.3 µg), NPY (5 µg) or saline. Alpha-MSH and CRF suppressed, NPY increased FI significantly. Administration of α-MSH considerably attenuated both spontaneous FI and re-feeding following 24-h fasting. The suppression of re-feeding varied between age groups: 22 % reduction was shown in juvenile, strong suppression (69 %) in young adult rats, which was attenuated by middle-age (56 % vs. 26 %), and was extreme (94 % vs. 74 %) in old animals. The catabolic effects of CRF were also weaker in middle-aged rats as compared to young ones. Anabolic NPY on the other hand showed an improved efficacy in the middle-aged and a decreased one in the old age group. Our experiments suggest characteristic age-related changes in the effects of central neuropeptides, which might contribute to the explanation of both the development of middle-aged obesity and sarcopenia in the old. OTKA 49321, PTE ÁOK-KA-34039-25/2009, GVOP-3.2.1.-2004-0271/3.0. Conference: IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010. Presentation Type: Poster Presentation Topic: Homeostatic and neuroendocrine systems Citation: Szabad ÁO, Schmidt A, Barcza Z, Balaskó M and Székely M (2010). Age-related alterations in the long-term regulation of food intake and body weight. Front. Neurosci. Conference Abstract: IBRO International Workshop 2010. doi: 10.3389/conf.fnins.2010.10.00132 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Apr 2010; Published Online: 28 Apr 2010. * Correspondence: Árpád O Szabad, University of Pécs, Department of Pathophysiology and Gerontology, Medical School, Pécs, Hungary, mmbalasko@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Árpád O Szabad Andreas Schmidt Zsófia Barcza Márta Balaskó Miklós Székely Google Árpád O Szabad Andreas Schmidt Zsófia Barcza Márta Balaskó Miklós Székely Google Scholar Árpád O Szabad Andreas Schmidt Zsófia Barcza Márta Balaskó Miklós Székely PubMed Árpád O Szabad Andreas Schmidt Zsófia Barcza Márta Balaskó Miklós Székely Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2314338399 title "Age-related alterations in the long-term regulation of food intake and body weight" @default.
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