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- W2314374611 abstract "Summary Inter- and intraindividual variability in pharmacokinetics of most drugs is largely determined by variable liver function as described by parameters of hep atic blood flow and metabolic capacity. These parameters may be altered as a result of disease affecting the liver, genetic differences in metabolising enzymes, and various types of drug interactions, including enzyme induction, enzyme in hibition or down-regulation. With the now known large number of drug metabolising enzymes, their dif ferential substrate specificity, and their differential induction or inhibition, each test substance of liver function should be used as a probe for its specific metabo lising enzyme. Thus, the concept of model test-substances providing general in formation about liver function has severe limitations . To test the metabolic activity of several enzymes, either several test substances may be given (cocktail ap proach) or several metabolites of a single test substance may be analysed (meta bolic fingerprint approach). The enzyme-specific analysis of liver function results in a preference for analysis of the metabolites rather than analysis of the clearance of the parent test substance." @default.
- W2314374611 created "2016-06-24" @default.
- W2314374611 creator A5001414279 @default.
- W2314374611 creator A5069565873 @default.
- W2314374611 date "1994-01-01" @default.
- W2314374611 modified "2023-09-27" @default.
- W2314374611 title "Assessment of Liver Metabolic Function Implications" @default.
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