Matches in SemOpenAlex for { <https://semopenalex.org/work/W2314398811> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2314398811 endingPage "1890" @default.
- W2314398811 startingPage "1885" @default.
- W2314398811 abstract "We show, in this study, that type I IFN induction of the cyclin-dependent kinase (cdk) inhibitor p21WAF1 in the human Burkitt lymphoma B cell-line Daudi and ensuing cell cycle arrest correlate with the terminal differentiation of these cells, and is ultimately followed by apoptosis and cell death. The expression of p21WAF1 paralleled the onset of G1 arrest and the reduction of surface IgM expression which was used as a marker of the differentiation response, and the IFN treated cells acquired a typical plasma cell-like morphology. The type II IFN IFNγ, which does not inhibit the growth of Daudi cells, did not induce the expression of p21WAF1, nor affect the expression of surface IgM. The induction of p21WAF1 which paralleled the inhibition of the phosphorylation of the retinoblastoma protein, pRB, was preceded by the strong reduction in c-myc levels. We propose that the coupled down-regulation of c-myc and induction of p21WAF1 may be crucial to the induction of differentiation and G1 arrest in Daudi cells by type I IFN. Growth arrest and differentiation was followed by apoptosis and cell death, and was accompanied by the induction of the activity of the apoptotic ICE-family protease CPP32. G1 arrest and differentiation followed by apoptotic cell death are characteristics of terminal differentiation. Thus, our data suggest that the induction of p21WAF1 and G1 arrest mediated by type I IFN in Daudi cells is part of terminal differentiation response in these cells, highlighting a role for type I IFN as B cell terminal differentiation factors." @default.
- W2314398811 created "2016-06-24" @default.
- W2314398811 creator A5023419211 @default.
- W2314398811 creator A5040070946 @default.
- W2314398811 creator A5045134210 @default.
- W2314398811 creator A5058073147 @default.
- W2314398811 date "1998-04-09" @default.
- W2314398811 modified "2023-10-16" @default.
- W2314398811 title "Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line" @default.
- W2314398811 doi "https://doi.org/10.1038/sj.onc.1201712" @default.
- W2314398811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9583686" @default.
- W2314398811 hasPublicationYear "1998" @default.
- W2314398811 type Work @default.
- W2314398811 sameAs 2314398811 @default.
- W2314398811 citedByCount "58" @default.
- W2314398811 countsByYear W23143988112012 @default.
- W2314398811 countsByYear W23143988112013 @default.
- W2314398811 countsByYear W23143988112014 @default.
- W2314398811 countsByYear W23143988112016 @default.
- W2314398811 countsByYear W23143988112017 @default.
- W2314398811 countsByYear W23143988112018 @default.
- W2314398811 countsByYear W23143988112020 @default.
- W2314398811 countsByYear W23143988112021 @default.
- W2314398811 countsByYear W23143988112023 @default.
- W2314398811 crossrefType "journal-article" @default.
- W2314398811 hasAuthorship W2314398811A5023419211 @default.
- W2314398811 hasAuthorship W2314398811A5040070946 @default.
- W2314398811 hasAuthorship W2314398811A5045134210 @default.
- W2314398811 hasAuthorship W2314398811A5058073147 @default.
- W2314398811 hasBestOaLocation W23143988111 @default.
- W2314398811 hasConcept C104317684 @default.
- W2314398811 hasConcept C105696609 @default.
- W2314398811 hasConcept C120089663 @default.
- W2314398811 hasConcept C124320809 @default.
- W2314398811 hasConcept C148738053 @default.
- W2314398811 hasConcept C153911025 @default.
- W2314398811 hasConcept C184235292 @default.
- W2314398811 hasConcept C190283241 @default.
- W2314398811 hasConcept C2776062698 @default.
- W2314398811 hasConcept C2778298596 @default.
- W2314398811 hasConcept C29537977 @default.
- W2314398811 hasConcept C31573885 @default.
- W2314398811 hasConcept C502942594 @default.
- W2314398811 hasConcept C54355233 @default.
- W2314398811 hasConcept C55493867 @default.
- W2314398811 hasConcept C81885089 @default.
- W2314398811 hasConcept C86803240 @default.
- W2314398811 hasConcept C95444343 @default.
- W2314398811 hasConceptScore W2314398811C104317684 @default.
- W2314398811 hasConceptScore W2314398811C105696609 @default.
- W2314398811 hasConceptScore W2314398811C120089663 @default.
- W2314398811 hasConceptScore W2314398811C124320809 @default.
- W2314398811 hasConceptScore W2314398811C148738053 @default.
- W2314398811 hasConceptScore W2314398811C153911025 @default.
- W2314398811 hasConceptScore W2314398811C184235292 @default.
- W2314398811 hasConceptScore W2314398811C190283241 @default.
- W2314398811 hasConceptScore W2314398811C2776062698 @default.
- W2314398811 hasConceptScore W2314398811C2778298596 @default.
- W2314398811 hasConceptScore W2314398811C29537977 @default.
- W2314398811 hasConceptScore W2314398811C31573885 @default.
- W2314398811 hasConceptScore W2314398811C502942594 @default.
- W2314398811 hasConceptScore W2314398811C54355233 @default.
- W2314398811 hasConceptScore W2314398811C55493867 @default.
- W2314398811 hasConceptScore W2314398811C81885089 @default.
- W2314398811 hasConceptScore W2314398811C86803240 @default.
- W2314398811 hasConceptScore W2314398811C95444343 @default.
- W2314398811 hasIssue "14" @default.
- W2314398811 hasLocation W23143988111 @default.
- W2314398811 hasLocation W23143988112 @default.
- W2314398811 hasOpenAccess W2314398811 @default.
- W2314398811 hasPrimaryLocation W23143988111 @default.
- W2314398811 hasRelatedWork W1964807859 @default.
- W2314398811 hasRelatedWork W1969340788 @default.
- W2314398811 hasRelatedWork W2010743730 @default.
- W2314398811 hasRelatedWork W2034103190 @default.
- W2314398811 hasRelatedWork W2066211494 @default.
- W2314398811 hasRelatedWork W2070226794 @default.
- W2314398811 hasRelatedWork W2080572933 @default.
- W2314398811 hasRelatedWork W2108416623 @default.
- W2314398811 hasRelatedWork W2141091145 @default.
- W2314398811 hasRelatedWork W2411155616 @default.
- W2314398811 hasVolume "16" @default.
- W2314398811 isParatext "false" @default.
- W2314398811 isRetracted "false" @default.
- W2314398811 magId "2314398811" @default.
- W2314398811 workType "article" @default.