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• W2314440796 abstract "Event Abstract Back to Event Carbon nanofibers (CNF) as scaffolds for osteochondral tissue regenerative medicine Ewa Stodolak-Zych1, Elżbieta Menaszek2, Piotr Szatkowski1, Aleksandra Mucha1 and Marta Blazewicz1 1 AGH-UST University of Science and Technology, Departament of Biomaterials, Poland 2 Jagiellonian University Medical College, Departament of Cytobiology, Poland Different forms of carbon are well known in biomedical applications. Some of them could be used separately (i.e. carbon nanotubes which play a role in gene delivery, drug targeting), while others play a role of additives in ceramic or polymer matrix (scaffolds with short carbon fibers, CNTs or graphene or composite system with long 1D or 2D carbon fibers used in biomechanical applications). Results of many different investigations showed successful application of carbon fibers in bone and cartilage tissue defects treatment as scaffolds or fibrous membranes inducting proliferation of osteoblast cells or initiating osteogenic effect[1],[2]. Amorphous structure, low Young’s modulus and possibilities to modification of carbon fibers by ceramic (nano)fillers (i.e. HA, TCP, SiO2) in the bulk but also in the surface create suitable properties of these materials. Moreover, microstructure combining fibers and particles seems to be the best composition which mimics natural bone and cartilage tissue. Novel possibilities of applications of carbon fibers in medicine can be granted by their nanometric form i.e. carbon nanofibers (CNF). This form can be obtained by various processes (reaction from a gas phase, pitch-based fibres and electrospinning process of polymer precursors and their subsequent carbonization of fibrous precursor). The carbon nanofibres, similarly to nanowires and nanotubes, belong to the group of one-dimensional nanometric objects. The nanofibers characterize by small cross section and a significant length, which corresponds to higher specific surface area than conventional fibres[3],[4]. The small diameter significantly affects amount of structural defects which in turn affects mechanical properties as well as specific surface properties. The carbon nanofibres can be used in treatment and stimulation of bone system as well as in construction of nanocomposite or fibrous substrates in in situ tissue engineering. Based on this information the aim of work was preparation and characterization of material properties of carbon nanofibers based on PAN precursor and assessment of their biological potential for stimulation of osteoblasts and chondrocyte cells. Nanometric fibrous materials (diameter of single fibers ~150 nm, Fig 1) with high total porosity (~75%) and amorphous structure were contacted with osteoblast-like cells line (MG63) and primary osteoblast line (NHOst). Cytotoxicity of the materials was tested after 7 days of incubation and measurement of the cells viability. Morphology of the cells was observed using a fluorescence microscope. Both types of the cells were characterized by larger proliferation than cells contacted with a reference samples (TCPS). The same preliminary tests were also made with chondrocyte cells. The work is supported by the National Science Center - Poland (Project no: UMO-2014/13/B/ST8/01195)References:[1] Pesakova, V., et al., Biomechanical and biological properties of the implant material carbon-carbon composite covered with pyrolytic carbon. J Mater Sci Mater Med, 2000. 11(12): p. 793-8.[2] Wolter, D., Biocompatibility of carbon fibre and carbon fibre microparticles. Aktuelle Probl Chir Orthop, 1983. 26: p. 28-36.[3] Hunziker, E.B., Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis and Cartilage, 2002. 10(6): p. 432-463.[4] Gliścińska E., Gutarowska B., Brycki B., Krucińska I. Electrospun polyacrylonitrile nanofibers modified by quaternary ammonium salts, Journal of Applied Polymer Science, 128(1), (2013), p. 767-775 Keywords: Cell Proliferation, Structure, nanofiber, 3D scaffold Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Synthetic scaffolds as extracellular matrices Citation: Stodolak-Zych E, Menaszek E, Szatkowski P, Mucha A and Blazewicz M (2016). Carbon nanofibers (CNF) as scaffolds for osteochondral tissue regenerative medicine. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02830 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ewa Stodolak-Zych Elżbieta Menaszek Piotr Szatkowski Aleksandra Mucha Marta Blazewicz Google Ewa Stodolak-Zych Elżbieta Menaszek Piotr Szatkowski Aleksandra Mucha Marta Blazewicz Google Scholar Ewa Stodolak-Zych Elżbieta Menaszek Piotr Szatkowski Aleksandra Mucha Marta Blazewicz PubMed Ewa Stodolak-Zych Elżbieta Menaszek Piotr Szatkowski Aleksandra Mucha Marta Blazewicz Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2314440796 title "Carbon nanofibers (CNF) as scaffolds for osteochondral tissue regenerative medicine" @default.
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